| Identification |
|---|
| HMDB Protein ID
| CDBP02844 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calpain small subunit 2 |
| Description
| Not Available |
| Synonyms
|
- CSS2
- Calcium-dependent protease small subunit 2
|
| Gene Name
| CAPNS2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease which catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. This small subunit may act as a tissue-specific chaperone of the large subunit, possibly by helping it fold into its correct conformation for activity |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Cell membrane
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 16q12.2 |
| SNPs
| CAPNS2 |
| Gene Sequence
|
>747 bp
ATGTTTCTTGCAAAGGCTCTATTGGAAGGAGCAGATCGAGGTCTTGGAGAAGCTCTTGGA
GGCCTCTTTGGAGGAGGTGGTCAGAGAAGAGAAGGAGGAGGAAGAAATATTGGAGGGATA
GTTGGAGGAATTGTGAATTTTATCAGTGAGGCTGCAGCAGCTCAGTATACTCCAGAACCG
CCTCCCACTCAGCAGCATTTCACCAGTGTGGAGGCCTCACAAAGTGAGGAAGTTAGGCGA
TTTCGGCAACAATTTACACAGCTGGCTGGACCAGACATGGAGGTGGGTGCCACTGATCTG
ATGAATATTCTCAACAAAGTCCTTTCTAAGCACAAAGATCTTAAGACTGACGGTTTTAGT
CTTGACACCTGCCGGAGCATTGTGTCTGTCATGGACAGTGACACGACTGGTAAGCTGGGC
TTTGAAGAATTTAAGTATCTGTGGAACAACATCAAGAAATGGCAGTGTGTTTATAAGCAG
TATGACAGGGACCATTCTGGGTCTCTGGGAAGTTCTCAGCTGCGGGGAGCTCTGCAGGCC
GCAGGCTTCCAGCTAAATGAACAACTTTACCAAATGATTGTCCGCCGGTATGCTAATGAA
GATGGAGATATGGATTTTAACAATTTCATCAGCTGCTTGGTCCGCCTGGATGCCATGTTT
CGTGCCTTCAAGTCTCTGGATAGAGATAGAGATGGCCTGATTCAAGTGTCTATCAAAGAA
TGGCTGCAGTTGACCATGTATTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 248 |
| Molecular Weight
| 27660.0 |
| Theoretical pI
| 5.41 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain small subunit 2
MFLAKALLEGADRGLGEALGGLFGGGGQRREGGGRNIGGIVGGIVNFISEAAAAQYTPEP
PPTQQHFTSVEASESEEVRRFRQQFTQLAGPDMEVGATDLMNILNKVLSKHKDLKTDGFS
LDTCRSIVSVMDSDTTGKLGFEEFKYLWNNIKKWQCVYKQYDRDHSGSLGSSQLRGALQA
AGFQLNEQLYQMIVRRYANEDGDMDFNNFISCLVRLDAMFRAFKSLDRDRDGLIQVSIKE
WLQLTMYS
|
| External Links |
|---|
| GenBank ID Protein
| 15667255 |
| UniProtKB/Swiss-Prot ID
| Q96L46 |
| UniProtKB/Swiss-Prot Entry Name
| CPNS2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY052551 |
| GeneCard ID
| CAPNS2 |
| GenAtlas ID
| CAPNS2 |
| HGNC ID
| HGNC:16371 |
| References |
|---|
| General References
| Not Available |