| Identification |
|---|
| HMDB Protein ID
| CDBP02833 |
| Secondary Accession Numbers
| Not Available |
| Name
| Collectin-12 |
| Description
| Not Available |
| Synonyms
|
- CL-P1
- Collectin placenta protein 1
- Nurse cell scavenger receptor 2
- Scavenger receptor class A member 4
- Scavenger receptor with C-type lectin
- hCL-P1
|
| Gene Name
| COLEC12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid beta in Alzheimer disease |
| GO Classification
|
| Function |
| binding |
| carbohydrate binding |
| sugar binding |
|
| Cellular Location
|
- Membrane
- Single-pass type II membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18pter-p11.3 |
| SNPs
| COLEC12 |
| Gene Sequence
|
>2229 bp
ATGAAAGACGACTTCGCAGAGGAGGAGGAGGTGCAATCCTTCGGTTACAAGCGGTTTGGT
ATTCAGGAAGGAACACAATGTACCAAATGTAAAAATAACTGGGCACTGAAGTTTTCTATC
ATATTATTATACATTTTGTGTGCCTTGCTAACAATCACAGTAGCCATTTTGGGATATAAA
GTTGTAGAGAAAATGGACAATGTCACAGGTGGCATGGAAACATCTCGCCAAACCTATGAT
GACAAGCTCACAGCAGTGGAAAGTGACCTGAAAAAATTAGGTGACCAAACTGGGAAGAAA
GCTATCAGCACCAACTCAGAACTCTCCACCTTCAGATCAGACATTCTAGATCTCCGTCAG
CAACTTCGTGAGATTACAGAAAAAACCAGCAAGAACAAGGATACGCTGGAGAAGTTACAG
GCGAGCGGGGATGCTCTGGTGGACAGGCAGAGTCAATTGAAAGAAACTTTGGAGAATAAC
TCTTTCCTCATCACCACTGTAAACAAAACCCTCCAGGCGTATAATGGCTATGTCACGAAT
CTGCAGCAAGATACCAGCGTGCTCCAGGGCAATCTGCAGAACCAAATGTATTCTCATAAT
GTGGTCATCATGAACCTCAACAACCTGAACCTGACCCAGGTGCAGCAGAGGAACCTCATC
ACGAATCTGCAGCGGTCTGTGGATGACACAAGCCAGGCTATCCAGCGAATCAAGAACGAC
TTTCAAAATCTGCAGCAGGTTTTTCTTCAAGCCAAGAAGGACACGGATTGGCTGAAGGAG
AAAGTGCAGAGCTTGCAGACGCTGGCTGCCAACAACTCTGCGTTGGCCAAAGCCAACAAC
GACACCCTGGAGGATATGAACAGCCAGCTCAACTCATTCACAGGTCAGATGGAGAACATC
ACCACTATCTCTCAAGCCAACGAGCAGAACCTGAAAGACCTGCAGGACTTACACAAAGAT
GCAGAGAATAGAACAGCCATCAAGTTCAACCAACTGGAGGAACGCTTCCAGCTCTTTGAG
ACGGATATTGTGAACATCATTAGCAATATCAGTTACACAGCCCACCACCTGCGGACGCTG
ACCAGCAATCTAAATGAAGTCAGGACCACTTGCACAGATACCCTTACCAAACACACAGAT
GATCTGACCTCCTTGAATAATACCCTGGCCAACATCCGTTTGGATTCTGTTTCTCTCAGG
ATGCAACAAGATTTGATGAGGTCGAGGTTAGACACTGAAGTAGCCAACTTATCAGTGATT
ATGGAAGAAATGAAGCTAGTAGACTCCAAGCATGGTCAGCTCATCAAGAATTTTACAATA
CTACAAGGTCCACCGGGCCCCAGGGGTCCAAGAGGTGACAGAGGATCCCAGGGACCCCCT
GGCCCAACTGGCAACAAGGGACAGAAAGGAGAGAAGGGGGAGCCTGGACCACCTGGCCCT
GCGGGTGAGAGAGGCCCAATTGGACCAGCTGGTCCCCCCGGAGAGCGTGGCGGCAAAGGA
TCTAAAGGCTCCCAGGGCCCCAAAGGCTCCCGTGGTTCCCCTGGGAAGCCCGGCCCTCAG
GGCCCCAGTGGGGACCCAGGCCCCCCGGGCCCACCAGGCAAAGAGGGACTCCCCGGCCCT
CAGGGCCCTCCTGGCTTCCAGGGACTTCAGGGCACCGTTGGGGAGCCTGGGGTGCCTGGA
CCTCGGGGACTGCCAGGCTTGCCTGGGGTACCAGGCATGCCAGGCCCCAAGGGCCCCCCC
GGCCCTCCTGGCCCATCAGGAGCGGTGGTGCCCCTGGCCCTGCAGAATGAGCCAACCCCG
GCACCGGAGGACAATGGCTGCCCGCCTCACTGGAAGAACTTCACAGACAAATGCTACTAT
TTTTCAGTTGAGAAAGAAATTTTTGAGGATGCAAAGCTTTTCTGTGAAGACAAGTCTTCA
CATCTTGTTTTCATAAACACTAGAGAGGAACAGCAATGGATAAAAAAACAGATGGTAGGG
AGAGAGAGCCACTGGATCGGCCTCACAGACTCAGAGCGTGAAAATGAATGGAAGTGGCTG
GATGGGACATCTCCAGACTACAAAAATTGGAAAGCTGGACAGCCGGATAACTGGGGTCAT
GGCCATGGGCCAGGAGAAGACTGTGCTGGGTTGATTTATGCTGGGCAGTGGAACGATTTC
CAATGTGAAGACGTCAATAACTTCATTTGCGAAAAAGACAGGGAGACAGTACTGTCATCT
GCATTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 742 |
| Molecular Weight
| 81514.7 |
| Theoretical pI
| 5.39 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Collectin-12
MKDDFAEEEEVQSFGYKRFGIQEGTQCTKCKNNWALKFSIILLYILCALLTITVAILGYK
VVEKMDNVTGGMETSRQTYDDKLTAVESDLKKLGDQTGKKAISTNSELSTFRSDILDLRQ
QLREITEKTSKNKDTLEKLQASGDALVDRQSQLKETLENNSFLITTVNKTLQAYNGYVTN
LQQDTSVLQGNLQNQMYSHNVVIMNLNNLNLTQVQQRNLITNLQRSVDDTSQAIQRIKND
FQNLQQVFLQAKKDTDWLKEKVQSLQTLAANNSALAKANNDTLEDMNSQLNSFTGQMENI
TTISQANEQNLKDLQDLHKDAENRTAIKFNQLEERFQLFETDIVNIISNISYTAHHLRTL
TSNLNEVRTTCTDTLTKHTDDLTSLNNTLANIRLDSVSLRMQQDLMRSRLDTEVANLSVI
MEEMKLVDSKHGQLIKNFTILQGPPGPRGPRGDRGSQGPPGPTGNKGQKGEKGEPGPPGP
AGERGPIGPAGPPGERGGKGSKGSQGPKGSRGSPGKPGPQGSSGDPGPPGPPGKEGLPGP
QGPPGFQGLQGTVGEPGVPGPRGLPGLPGVPGMPGPKGPPGPPGPSGAVVPLALQNEPTP
APEDNGCPPHWKNFTDKCYYFSVEKEIFEDAKLFCEDKSSHLVFINTREEQQWIKKQMVG
RESHWIGLTDSERENEWKWLDGTSPDYKNWKAGQPDNWGHGHGPGEDCAGLIYAGQWNDF
QCEDVNNFICEKDRETVLSSAL
|
| External Links |
|---|
| GenBank ID Protein
| 17026101 |
| UniProtKB/Swiss-Prot ID
| Q5KU26 |
| UniProtKB/Swiss-Prot Entry Name
| COL12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB005145 |
| GeneCard ID
| COLEC12 |
| GenAtlas ID
| COLEC12 |
| HGNC ID
| HGNC:16016 |
| References |
|---|
| General References
| Not Available |