| Identification |
|---|
| HMDB Protein ID
| CDBP02818 |
| Secondary Accession Numbers
| Not Available |
| Name
| Claudin-1 |
| Description
| Not Available |
| Synonyms
|
- Senescence-associated epithelial membrane protein
|
| Gene Name
| CLDN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in structural molecule activity |
| Specific Function
| Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity. Acts as a co- receptor for HCV entry into hepatic cells |
| GO Classification
|
| Component |
| cell-cell junction |
| occluding junction |
| tight junction |
| membrane |
| cell part |
| membrane part |
| plasma membrane part |
| cell junction |
| Function |
| structural molecule activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3q28-q29 |
| SNPs
| CLDN1 |
| Gene Sequence
|
>636 bp
ATGGCCAACGCGGGGCTGCAGCTGTTGGGCTTCATTCTCGCCTTCCTGGGATGGATCGGC
GCCATCGTCAGCACTGCCCTGCCCCAGTGGAGGATTTACTCCTATGCCGGCGACAACATC
GTGACCGCCCAGGCCATGTACGAGGGGCTGTGGATGTCCTGCGTGTCGCAGAGCACCGGG
CAGATCCAGTGCAAAGTCTTTGACTCCTTGCTGAATCTGAGCAGCACATTGCAAGCAACC
CGTGCCTTGATGGTGGTTGGCATCCTCCTGGGAGTGATAGCAATCTTTGTGGCCACCGTT
GGCATGAAGTGTATGAAGTGCTTGGAAGACGATGAGGTGCAGAAGATGAGGATGGCTGTC
ATTGGGGGTGCGATATTTCTTCTTGCAGGTCTGGCTATTTTAGTTGCCACAGCATGGTAT
GGCAATAGAATCGTTCAAGAATTCTATGACCCTATGACCCCAGTCAATGCCAGGTACGAA
TTTGGTCAGGCTCTCTTCACTGGCTGGGCTGCTGCTTCTCTCTGCCTTCTGGGAGGTGCC
CTACTTTGCTGTTCCTGTCCCCGAAAAACAACCTCTTACCCAACACCAAGGCCCTATCCA
AAACCTGCACCTTCCAGCGGGAAAGACTACGTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 211 |
| Molecular Weight
| 22743.6 |
| Theoretical pI
| 8.18 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["8-28", "82-102", "116-136", "164-184"]
|
| Protein Sequence
|
>Claudin-1
MANAGLQLLGFILAFLGWIGAIVSTALPQWRIYSYAGDNIVTAQAMYEGLWMSCVSQSTG
QIQCKVFDSLLNLSSTLQATRALMVVGILLGVIAIFVATVGMKCMKCLEDDEVQKMRMAV
IGGAIFLLAGLAILVATAWYGNRIVQEFYDPMTPVNARYEFGQALFTGWAAASLCLLGGA
LLCCSCPRKTTSYPTPRPYPKPAPSSGKDYV
|
| External Links |
|---|
| GenBank ID Protein
| 4323581 |
| UniProtKB/Swiss-Prot ID
| O95832 |
| UniProtKB/Swiss-Prot Entry Name
| CLD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF101051 |
| GeneCard ID
| CLDN1 |
| GenAtlas ID
| CLDN1 |
| HGNC ID
| HGNC:2032 |
| References |
|---|
| General References
| Not Available |