| Identification |
|---|
| HMDB Protein ID
| CDBP02811 |
| Secondary Accession Numbers
| Not Available |
| Name
| Claudin-12 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| CLDN12 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in structural molecule activity |
| Specific Function
| Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium- independent cell-adhesion activity |
| GO Classification
|
| Component |
| cell-cell junction |
| occluding junction |
| tight junction |
| cell part |
| membrane part |
| plasma membrane part |
| cell junction |
| Function |
| structural molecule activity |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:7 |
| Locus
| 7q21 |
| SNPs
| CLDN12 |
| Gene Sequence
|
>735 bp
ATGGGCTGTCGGGATGTCCACGCAGCCACAGTCCTTTCCTTCCTGTGTGGAATCGCCTCA
GTAGCAGGCCTCTTTGCAGGGACTCTGCTTCCCAACTGGAGAAAATTACGATTGATCACA
TTCAACAGAAACGAGAAGAACCTGACTGTTTACACAGGCCTGTGGGTGAAATGTGCCCGG
TATGACGGGAGCAGTGACTGCCTGATGTACGACACTACTTGGTACTCATCAGTTGACCAG
CTGGACCTGCGTGTCCTCCAGTTTGCCCTACCCCTCAGCATGCTGATCGCCATGGGTGCC
CTGCTGCTCTGCCTGATTGGAATGTGCAACACTGCCTTCAGGTCCTCGGTGCCCAACATC
AAACTGGCCAAGTGTCTGGTCAATAGTGCAGGTTGCCACCTGGTGGCTGGGCTGCTATTT
TTCCTGGCAGGTACTGTGAGCCTCTCCCCATCTATCTGGGTCATCTTTTATAACATCCAT
CTGAACAAGAAGTTTGAGCCAGTCTTTTCATTTGACTATGCAGTGTATGTCACTATTGCT
AGTGCTGGGGGCCTGTTTATGACTTCCCTTATACTATTTATTTGGTATTGTACATGCAAA
TCTTTGCCTTCTCCTTTCTGGCAACCATTGTACTCCCATCCACCCAGTATGCATACTTAC
TCACAGCCCTATTCAGCACGCTCTCGCCTCTCTGCCATTGAAATTGACATTCCAGTAGTT
TCACACACCACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 244 |
| Molecular Weight
| 27109.5 |
| Theoretical pI
| 8.54 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
- ["11-31", "88-108", "136-156", "175-195"]
|
| Protein Sequence
|
>Claudin-12
MGCRDVHAATVLSFLCGIASVAGLFAGTLLPNWRKLRLITFNRNEKNLTVYTGLWVKCAR
YDGSSDCLMYDTTWYSSVDQLDLRVLQFALPLSMLIAMGALLLCLIGMCNTAFRSSVPNI
KLAKCLVNSAGCHLVAGLLFFLAGTVSLSPSIWVIFYNIHLNKKFEPVFSFDYAVYVTIA
SAGGLFMTSLILFIWYCTCKSLPSPFWQPLYSHPPSMHTYSQPYSARSRLSAIEIDIPVV
SHTT
|
| External Links |
|---|
| GenBank ID Protein
| 30172723 |
| UniProtKB/Swiss-Prot ID
| P56749 |
| UniProtKB/Swiss-Prot Entry Name
| CLD12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AC006153 |
| GeneCard ID
| CLDN12 |
| GenAtlas ID
| CLDN12 |
| HGNC ID
| HGNC:2034 |
| References |
|---|
| General References
| Not Available |