| Identification |
|---|
| HMDB Protein ID
| CDBP02807 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcium-activated chloride channel regulator 2 |
| Description
| Not Available |
| Synonyms
|
- CaCC-3
- Calcium-activated chloride channel family member 2
- Calcium-activated chloride channel protein 3
- Calcium-activated chloride channel regulator 2, 109 kDa form
- Calcium-activated chloride channel regulator 2, 35 kDa form
- hCLCA2
- hCaCC-3
|
| Gene Name
| CLCA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| Play a role in modulating chloride current across the plasma membrane in a calcium-dependent manner, and cell adhesion. Involved in basal cell adhesion and/or stratification of squamous epithelia. May act as a tumor suppressor in breast and colorectal cancer. Plays a key role for cell adhesion in the beginning stages of lung metastasis via the binding to ITGB4 |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Calcium-activated chloride channel regulator 2
- 109 kDa form:Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p22.3 |
| SNPs
| CLCA2 |
| Gene Sequence
|
>2832 bp
ATGACCCAAAGGAGCATTGCAGGTCCTATTTGCAACCTGAAGTTTGTGACTCTCCTGGTT
GCCTTAAGTTCAGAACTCCCATTCCTGGGAGCTGGAGTACAGCTTCAAGACAATGGGTAT
AATGGATTGCTCATTGCCATTAATCCTCAGGTACCTGAGAATCAGAACCTCATCTCAAAC
ATTAAGGAAATGATAACTGAAGCTTCATTTTACCTATTTAATGCTACCAAGAGAAGAGTA
TTTTTCAGAAATATAAAGATTTTAATACCTGCCACATGGAAAGCTAATAATAACAGCAAA
ATAAAACAAGAATCATATGAAAAGGCAAATGTCATAGTGACTGACTGGTATGGGGCACAT
GGAGATGATCCATACACCCTACAATACAGAGGGTGTGGAAAAGAGGGAAAATACATTCAT
TTCACACCTAATTTCCTACTGAATGATAACTTAACAGCTGGCTACGGATCACGAGGCCGA
GTGTTTGTCCATGAATGGGCCCACCTCCGTTGGGGTGTGTTCGATGAGTATATCAATGAC
AAACCTTTCTACATAAATGGGCAAAATCAAATTAAAGTGACAAGGTGTTCATCTGACATC
ACAGGCATTTTTGTGTGTGAAAAAGGTCCTTGCCCCCAAGAAAACTGTATTATTAGTAAG
CTTTTTAAAGAAGGATGCACCTTTATCTACAATAGCACCCAAAATGCAACTGCATCAATA
ATGTTCATGCAAAGTTTATCTTCTGTGGTTGAATTTTGTAATGCAAGTACCCACAACCAA
GAAGCACCAAACCTACAGAACCAGATGTGCAGCCTCAGAAGTGCATGGGATGTAATCACA
GACTCTGCTGACTTTCACCACAGCTTTCCCATGAATGGGACTGAGCTTCCACCTCCTCCC
ACATTCTCGCTTGTACAGGCTGGCGACAAAGTGGTCTGTTTAGTGCTGGATGTGTCCAGC
AAGATGGCAGAGGCTGACAGACTCCTTCAACTACAACAAGCCGCAGAATTTTATTTGATG
CAGATTGTTGAAATTCATACCTTCGTGGGCATTGCCAGTTTCGACAGCAAAGGAGAGATC
AGAGCCCAGCTACACCAAATTAACAGCAATGATGATCGAAAGTTGCTGGTTTCATATCTG
CCCACCACTGTATCAGCTAAAACAGACATCAGCATTTGTTCAGGGCTTAAGAAAGGATTT
GAGGTGGTTGAAAAACTGAATGGAAAAGCTTATGGCTCTGTGATGATATTAGTGACCAGC
GGAGATGATAAGCTTCTTGGCAATTGCTTACCCACTGTGCTCAGCAGTGGTTCAACAATT
CACTCCATTGCCCTGGGTTCATCTGCAGCCCCAAATCTGGAGGAATTATCACGTCTTACA
GGAGGTTTAAAGTTCTTTGTTCCAGATATATCAAACTCCAATAGCATGATTGATGCTTTC
AGTAGAATTTCCTCTGGAACTGGAGACATTTTCCAGCAACATATTCAGCTTGAAAGTACA
GGTGAAAATGTCAAACCTCACCATCAATTGAAAAACACAGTGACTGTGGATAATACTGTG
GGCAACGACACTATGTTTCTAGTTACGTGGCAGGCCAGTGGTCCTCCTGAGATTATATTA
TTTGATCCTGATGGACGAAAATACTACACAAATAATTTTATCACCAATCTAACTTTTCGG
ACAGCTAGTCTTTGGATTCCAGGAACAGCTAAGCCTGGGCACTGGACTTACACCCTGAAC
AATACCCATCATTCTCTGCAAGCCCTGAAAGTGACAGTGACCTCTCGCGCCTCCAACTCA
GCTGTGCCCCCAGCCACTGTGGAAGCCTTTGTGGAAAGAGACAGCCTCCATTTTCCTCAT
CCTGTGATGATTTATGCCAATGTGAAACAGGGATTTTATCCCATTCTTAATGCCACTGTC
ACTGCCACAGTTGAGCCAGAGACTGGAGATCCTGTTACGCTGAGACTCCTTGATGATGGA
GCAGGTGCTGATGTTATAAAAAATGATGGAATTTACTCGAGGTATTTTTTCTCCTTTGCT
GCAAATGGTAGATATAGCTTGAAAGTGCATGTCAATCACTCTCCCAGCATAAGCACCCCA
GCCCACTCTATTCCAGGGAGTCATGCTATGTATGTACCAGGTTACACAGCAAACGGTAAT
ATTCAGATGAATGCTCCAAGGAAATCAGTAGGCAGAAATGAGGAGGAGCGAAAGTGGGGC
TTTAGCCGAGTCAGCTCAGGAGGCTCCTTTTCAGTGCTGGGAGTTCCAGCTGGCCCCCAC
CCTGATGTGTTTCCACCATGCAAAATTATTGACCTGGAAGCTGTAAAAGTAGAAGAGGAA
TTGACCCTATCTTGGACAGCACCTGGAGAAGACTTTGATCAGGGCCAGGCTACAAGCTAT
GAAATAAGAATGAGTAAAAGTCTACAGAATATCCAAGATGACTTTAACAATGCTATTTTA
GTAAATACATCAAAGCGAAATCCTCAGCAAGCTGGCATCAGGGAGATATTTACGTTCTCA
CCCCAAATTTCCACGAATGGACCTGAACATCAGCCAAATGGAGAAACACATGAAAGCCAC
AGAATTTATGTTGCAATACGAGCAATGGATAGGAACTCCTTACAGTCTGCTGTATCTAAC
ATTGCCCAGGCGCCTCTGTTTATTCCCCCCAATTCTGATCCTGTACCTGCCAGAGATTAT
CTTATATTGAAAGGAGTTTTAACAGCAATGGGTTTGATAGGAATCATTTGCCTTATTATA
GTTGTGACACATCATACTTTAAGCAGGAAAAAGAGAGCAGACAAGAAAGAGAATGGAACA
AAATTATTATAA
|
| Protein Properties |
|---|
| Number of Residues
| 943 |
| Molecular Weight
| 103940.0 |
| Theoretical pI
| 7.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcium-activated chloride channel regulator 2
MTQRSIAGPICNLKFVTLLVALSSELPFLGAGVQLQDNGYNGLLIAINPQVPENQNLISN
IKEMITEASFYLFNATKRRVFFRNIKILIPATWKANNNSKIKQESYEKANVIVTDWYGAH
GDDPYTLQYRGCGKEGKYIHFTPNFLLNDNLTAGYGSRGRVFVHEWAHLRWGVFDEYNND
KPFYINGQNQIKVTRCSSDITGIFVCEKGPCPQENCIISKLFKEGCTFIYNSTQNATASI
MFMQSLSSVVEFCNASTHNQEAPNLQNQMCSLRSAWDVITDSADFHHSFPMNGTELPPPP
TFSLVQAGDKVVCLVLDVSSKMAEADRLLQLQQAAEFYLMQIVEIHTFVGIASFDSKGEI
RAQLHQINSNDDRKLLVSYLPTTVSAKTDISICSGLKKGFEVVEKLNGKAYGSVMILVTS
GDDKLLGNCLPTVLSSGSTIHSIALGSSAAPNLEELSRLTGGLKFFVPDISNSNSMIDAF
SRISSGTGDIFQQHIQLESTGENVKPHHQLKNTVTVDNTVGNDTMFLVTWQASGPPEIIL
FDPDGRKYYTNNFITNLTFRTASLWIPGTAKPGHWTYTLNNTHHSLQALKVTVTSRASNS
AVPPATVEAFVERDSLHFPHPVMIYANVKQGFYPILNATVTATVEPETGDPVTLRLLDDG
AGADVIKNDGIYSRYFFSFAANGRYSLKVHVNHSPSISTPAHSIPGSHAMYVPGYTANGN
IQMNAPRKSVGRNEEERKWGFSRVSSGGSFSVLGVPAGPHPDVFPPCKIIDLEAVKVEEE
LTLSWTAPGEDFDQGQATSYEIRMSKSLQNIQDDFNNAILVNTSKRNPQQAGIREIFTFS
PQISTNGPEHQPNGETHESHRIYVAIRAMDRNSLQSAVSNIAQAPLFIPPNSDPVPARDY
LILKGVLTAMGLIGIICLIIVVTHHTLSRKKRADKKENGTKLL
|
| External Links |
|---|
| GenBank ID Protein
| 4887601 |
| UniProtKB/Swiss-Prot ID
| Q9UQC9 |
| UniProtKB/Swiss-Prot Entry Name
| CLCA2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB026833 |
| GeneCard ID
| CLCA2 |
| GenAtlas ID
| CLCA2 |
| HGNC ID
| HGNC:2016 |
| References |
|---|
| General References
| Not Available |