| Identification |
|---|
| HMDB Protein ID
| CDBP02798 |
| Secondary Accession Numbers
| Not Available |
| Name
| Centrin-2 |
| Description
| Not Available |
| Synonyms
|
- Caltractin isoform 1
|
| Gene Name
| CETN2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Plays a fundamental role in microtubule-organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CEP110 |
| GO Classification
|
| Function |
| atp-dependent helicase activity |
| atpase activity |
| atpase activity, coupled |
| nucleic acid binding |
| nucleoside-triphosphatase activity |
| calcium ion binding |
| ion binding |
| hydrolase activity, acting on acid anhydrides |
| cation binding |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| metal ion binding |
| pyrophosphatase activity |
| binding |
| catalytic activity |
| hydrolase activity |
| nucleoside binding |
| purine nucleoside binding |
| adenyl nucleotide binding |
| adenyl ribonucleotide binding |
| atp binding |
|
| Cellular Location
|
- Cytoplasm
- cytoskeleton
- centrosome
- centriole
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| CETN2 |
| Gene Sequence
|
>519 bp
ATGGCCTCCAACTTTAAGAAGGCAAACATGGCATCAAGTTCTCAGCGAAAAAGAATGAGC
CCTAAGCCTGAGCTTACTGAAGAGCAAAAGCAGGAGATCCGGGAAGCTTTTGATCTTTTC
GATGCGGATGGAACTGGCACCATAGATGTTAAAGAACTGAAGGTGGCAATGAGGGCCCTG
GGCTTTGAACCCAAGAAAGAAGAAATTAAGAAAATGATAAGTGAAATTGATAAGGAAGGG
ACAGGAAAAATGAACTTTGGTGACTTTTTAACTGTGATGACCCAGAAAATGTCTGAGAAA
GATACTAAAGAAGAAATCCTGAAAGCTTTCAAGCTCTTTGATGATGATGAAACTGGGAAG
ATTTCGTTCAAAAATCTGAAACGCGTGGCCAAGGAGTTGGGTGAGAACCTGACTGATGAG
GAGCTGCAGGAAATGATTGATGAAGCTGATCGAGATGGAGATGGAGAGGTCAGTGAGCAA
GAGTTCCTGCGCATCATGAAAAAGACCAGCCTCTATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 172 |
| Molecular Weight
| 19738.3 |
| Theoretical pI
| 4.62 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Centrin-2
MASNFKKANMASSSQRKRMSPKPELTEEQKQEIREAFDLFDADGTGTIDVKELKVAMRAL
GFEPKKEEIKKMISEIDKEGTGKMNFGDFLTVMTQKMSEKDTKEEILKAFKLFDDDETGK
ISFKNLKRVAKELGENLTDEELQEMIDEADRDGDGEVSEQEFLRIMKKTSLY
|
| External Links |
|---|
| GenBank ID Protein
| 189065158 |
| UniProtKB/Swiss-Prot ID
| P41208 |
| UniProtKB/Swiss-Prot Entry Name
| CETN2_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK311940 |
| GeneCard ID
| CETN2 |
| GenAtlas ID
| CETN2 |
| HGNC ID
| HGNC:1867 |
| References |
|---|
| General References
| Not Available |