| Identification |
|---|
| HMDB Protein ID
| CDBP02793 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C chemokine receptor type 5 |
| Description
| Not Available |
| Synonyms
|
- C-C CKR-5
- CC-CKR-5
- CCR-5
- CCR5
- CD195 antigen
- CHEMR13
- HIV-1 fusion coreceptor
|
| Gene Name
| CCR5 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation. Acts as a coreceptor (CD4 being the primary receptor) for HIV-1 R5 isolates |
| GO Classification
|
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| receptor activity |
| g-protein chemoattractant receptor activity |
| chemokine receptor activity |
| c-c chemokine receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.31 |
| SNPs
| CCR5 |
| Gene Sequence
|
>1059 bp
ATGGATTATCAAGTGTCAAGTCCAATCTATGACATCAATTATTATACATCGGAGCCCTGC
CAAAAAATCAATGTGAAGCAAATCGCAGCCCGCCTCCTGCCTCCGCTCTACTCACTGGTG
TTCATCTTTGGTTTTGTGGGCAACATGCTGGTCATCCTCATCCTGATAAACTGCAAAAGG
CTGAAGAGCATGACTGACATCTACCTGCTCAACCTGGCCATCTCTGACCTGTTTTTCCTT
CTTACTGTCCCCTTCTGGGCTCACTATGCTGCCGCCCAGTGGGACTTTGGAAATACAATG
TGTCAACTCTTGACAGGGCTCTATTTTATAGGCTTCTTCTCTGGAATCTTCTTCATCATC
CTCCTGACAATCGATAGGTACCTGGCTGTCGTCCATGCTGTGTTTGCTTTAAAAGCCAGG
ACGGTCACCTTTGGGGTGGTGACAAGTGTGATCACTTGGGTGGTGGCTGTGTTTGCGTCT
CTCCCAGGAATCATCTTTACCAGATCTCAAAAAGAAGGTCTTCATTACACCTGCAGCTCT
CATTTTCCATACAGTCAGTATCAATTCTGGAAGAATTTCCAGACATTAAAGATAGTCATC
TTGGGGCTGGTCCTGCCGCTGCTTGTCATGGTCATCTGCTACTCGGGAATCCTAAAAACT
CTGCTTCGGTGTCGAAATGAGAAGAAGAGGCACAGGGCTGTGAGGCTTATCTTCACCATC
ATGATTGTTTATTTTCTCTTCTGGGCTCCCTACAACATTGTCCTTCTCCTGAACACCTTC
CAGGAATTCTTTGGCCTGAATAATTGCAGTAGCTCTAACAGGTTGGACCAAGCTATGCAG
GTGACAGAGACTCTTGGGATGACGCACTGCTGCATCAACCCCATCATCTATGCCTTTGTC
GGGGAGAAGTTCAGAAACTACCTCTTAGTCTTCTTCCAAAAGCACATTGCCAAACGCTTC
TGCAAATGCTGTTCTATTTTCCAGCAAGAGGCTCCCGAGCGAGCAAGCTCAGTTTACACC
CGATCCACTGGGGAGCAGGAAATATCTGTGGGCTTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 352 |
| Molecular Weight
| 40523.6 |
| Theoretical pI
| 9.18 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["31-58", "69-89", "103-124", "142-166", "199-218", "236-260", "278-301"]
|
| Protein Sequence
|
>C-C chemokine receptor type 5
MDYQVSSPIYDINYYTSEPCQKINVKQIAARLLPPLYSLVFIFGFVGNMLVILILINCKR
LKSMTDIYLLNLAISDLFFLLTVPFWAHYAAAQWDFGNTMCQLLTGLYFIGFFSGIFFII
LLTIDRYLAVVHAVFALKARTVTFGVVTSVITWVVAVFASLPGIIFTRSQKEGLHYTCSS
HFPYSQYQFWKNFQTLKIVILGLVLPLLVMVICYSGILKTLLRCRNEKKRHRAVRLIFTI
MIVYFLFWAPYNIVLLLNTFQEFFGLNNCSSSNRLDQAMQVTETLGMTHCCINPIIYAFV
GEKFRNYLLVFFQKHIAKRFCKCCSIFQQEAPERASSVYTRSTGEQEISVGL
|
| External Links |
|---|
| GenBank ID Protein
| 1457946 |
| UniProtKB/Swiss-Prot ID
| P51681 |
| UniProtKB/Swiss-Prot Entry Name
| CCR5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| U54994 |
| GeneCard ID
| CCR5 |
| GenAtlas ID
| CCR5 |
| HGNC ID
| HGNC:1606 |
| References |
|---|
| General References
| Not Available |