| Identification |
|---|
| HMDB Protein ID
| CDBP02791 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C chemokine receptor type 3 |
| Description
| Not Available |
| Synonyms
|
- C-C CKR-3
- CC-CKR-3
- CCR-3
- CCR3
- CD193 antigen
- CKR3
- Eosinophil eotaxin receptor
|
| Gene Name
| CCR3 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| receptor activity |
| g-protein chemoattractant receptor activity |
| chemokine receptor activity |
| c-c chemokine receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| g-protein coupled receptor protein signaling pathway |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p21.3 |
| SNPs
| CCR3 |
| Gene Sequence
|
>1068 bp
ATGACAACCTCACTAGATACAGTTGAGACCTTTGGTACCACATCCTACTATGATGACGTG
GGCCTGCTCTGTGAAAAAGCTGATACCAGAGCACTGATGGCCCAGTTTGTGCCCCCGCTG
TACTCCCTGGTGTTCACTGTGGGCCTCTTGGGCAATGTGGTGGTGGTGATGATCCTCATA
AAATACAGGAGGCTCCGAATTATGACCAACATCTACCTGCTCAACCTGGCCATTTCGGAC
CTGCTCTTCCTCGTCACCCTTCCATTCTGGATCCACTATGTCAGGGGGCATAACTGGGTT
TTTGGCCATGGCATGTGTAAGCTCCTCTCAGGGTTTTATCACACAGGCTTGTACAGCGAG
ATCTTTTTCATAATCCTGCTGACAATCGACAGGTACCTGGCCATTGTCCATGCTGTGTTT
GCCCTTCGAGCCCGGACTGTCACTTTTGGTGTCATCACCAGCATCGTCACCTGGGGCCTG
GCAGTGCTAGCAGCTCTTCCTGAATTTATCTTCTATGAGACTGAAGAGTTGTTTGAAGAG
ACTCTTTGCAGTGCTCTTTACCCAGAGGATACAGTATATAGCTGGAGGCATTTCCACACT
CTGAGAATGACCATCTTCTGTCTCGTTCTCCCTCTGCTCGTTATGGCCATCAGCTACACA
GGAATCATCAAAACGCTGCTGAGGTGCCCCAGTAAAAAAAAGTACAAGGCCATCCGGCTC
ATTTTTGTCATCATGGCGGTGTTTTTCATTTTCTGGACACCCTACAATGTGGCTATCCTT
CTCTCTTCCTATCAATCCATCTTATTTGGAAATGACTGTGAGCGGACGAAGCATCTGGAC
CTGGTCATGCTGGTGACAGAGGTGATCGCCTACTCCCACTGCTGCATGAACCCGGTGATC
TACGCCTTTGTTGGAGAGAGGTTCCGGAAGTACCTGCGCCACTTCTTCCACAGGCACTTG
CTCATGCACCTGGGCAGATACATCCCATTCCTTCCTAGTGAGAAGCTGGAAAGAACCAGC
TCTGTCTCTCCATCCACAGCAGAGCCGGAACTCTCTATTGTGTTTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 355 |
| Molecular Weight
| 41043.3 |
| Theoretical pI
| 8.31 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["35-62", "73-93", "108-129", "147-171", "204-223", "240-264", "282-305"]
|
| Protein Sequence
|
>C-C chemokine receptor type 3
MTTSLDTVETFGTTSYYDDVGLLCEKADTRALMAQFVPPLYSLVFTVGLLGNVVVVMILI
KYRRLRIMTNIYLLNLAISDLLFLVTLPFWIHYVRGHNWVFGHGMCKLLSGFYHTGLYSE
IFFIILLTIDRYLAIVHAVFALRARTVTFGVITSIVTWGLAVLAALPEFIFYETEELFEE
TLCSALYPEDTVYSWRHFHTLRMTIFCLVLPLLVMAICYTGIIKTLLRCPSKKKYKAIRL
IFVIMAVFFIFWTPYNVAILLSSYQSILFGNDCERSKHLDLVMLVTEVIAYSHCCMNPVI
YAFVGERFRKYLRHFFHRHLLMHLGRYIPFLPSEKLERTSSVSPSTAEPELSIVF
|
| External Links |
|---|
| GenBank ID Protein
| 6467133 |
| UniProtKB/Swiss-Prot ID
| P51677 |
| UniProtKB/Swiss-Prot Entry Name
| CCR3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB023887 |
| GeneCard ID
| CCR3 |
| GenAtlas ID
| CCR3 |
| HGNC ID
| HGNC:1604 |
| References |
|---|
| General References
| Not Available |