| Identification |
|---|
| HMDB Protein ID
| CDBP02786 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-C motif chemokine 16 |
| Description
| Not Available |
| Synonyms
|
- Chemokine CC-4
- Chemokine LEC
- HCC-4
- IL-10-inducible chemokine
- LCC-1
- LMC
- Liver-expressed chemokine
- Lymphocyte and monocyte chemoattractant
- MTN-1
- Monotactin-1
- NCC-4
- Small-inducible cytokine A16
|
| Gene Name
| CCL16 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in chemokine activity |
| Specific Function
| Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| cytokine activity |
| chemokine activity |
| binding |
| protein binding |
| receptor binding |
| Process |
| immune response |
| immune system process |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q11.2 |
| SNPs
| CCL16 |
| Gene Sequence
|
>363 bp
ATGAAGGTCTCCGAGGCTGCCCTGTCTCTCCTTGTCCTCATCCTTATCATTACTTCGGCT
TCTCGCAGCCAGCCAAAAGTTCCTGAGTGGGTGAACACCCCATCCACCTGCTGCCTGAAG
TATTATGAGAAAGTGTTGCCAAGGAGACTAGTGGTGGGATACAGAAAGGCCCTCAACTGT
CACCTGCCAGCAATCATCTTCGTCACCAAGAGGAACCGAGAAGTCTGCACCAACCCCAAT
GACGACTGGGTCCAAGAGTACATCAAGGATCCCAACCTACCTTTGCTGCCTACCAGGAAC
TTGTCCACGGTTAAAATTATTACAGCAAAGAATGGTCAACCCCAGCTCCTCAACTCCCAG
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 120 |
| Molecular Weight
| 13599.9 |
| Theoretical pI
| 10.03 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>C-C motif chemokine 16
MKVSEAALSLLVLILIITSASRSQPKVPEWVNTPSTCCLKYYEKVLPRRLVVGYRKALNC
HLPAIIFVTKRNREVCTNPNDDWVQEYIKDPNLPLLPTRNLSTVKIITAKNGQPQLLNSQ
|
| External Links |
|---|
| GenBank ID Protein
| 2723286 |
| UniProtKB/Swiss-Prot ID
| O15467 |
| UniProtKB/Swiss-Prot Entry Name
| CCL16_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB007454 |
| GeneCard ID
| CCL16 |
| GenAtlas ID
| CCL16 |
| HGNC ID
| HGNC:10614 |
| References |
|---|
| General References
| Not Available |