| Identification |
|---|
| HMDB Protein ID
| CDBP02770 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calsequestrin-1 |
| Description
| Not Available |
| Synonyms
|
- Calmitin
- Calsequestrin, skeletal muscle isoform
|
| Gene Name
| CASQ1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction. Binds 40 to 50 moles of calcium. Also binds laminin |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Mitochondrion
- Sarcoplasmic reticulum lumen
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21 |
| SNPs
| CASQ1 |
| Gene Sequence
|
>1173 bp
ATGGGGCCCAGAGCTGTGCCGGGTCTGCGGCTGGCACTGCTGTTGCTGCTGGTGCTAGGG
ACACCCAAGTCAGGGGTACAGGGGCAGGAAGGGCTGGACTTCCCTGAGTACGATGGTGTG
GACCGTGTGATCAATGTCAATGCAAAGAACTACAAGAATGTGTTCAAGAAGTATGAGGTG
CTGGCACTCCTCTACCATGAACCCCCCGAGGATGACAAGGCCTCACAAAGACAATTTGAG
ATGGAGGAGCTGATCCTGGAGTTAGCAGCCCAAGTCCTAGAAGACAAGGGTGTTGGCTTC
GGGCTGGTAGACTCTGAGAAGGATGCAGCTGTGGCCAAGAAACTAGGCCTAACTGAAGTG
GACAGCATGTATGTATTCAAGGGAGATGAAGTCATTGAGTACGATGGCGAGTTTTCTGCT
GACACCATCGTGGAGTTTCTGCTTGATGTCCTAGAGGACCCTGTGGAATTGATTGAAGGT
GAACGAGAGCTGCAGGCGTTTGAGAATATTGAGGATGAGATCAAACTCATTGGCTACTTC
AAGAGCAAAGACTCAGAGCATTACAAAGCCTTCGAGGATGCAGCTGAGGAGTTTCATCCC
TACATCCCCTTCTTCGCCACCTTCGACAGCAAGGTGGCAAAGAAGCTGACCCTGAAGCTG
AATGAGATTGATTTCTACGAGGCCTTCATGGAAGAGCCTGTGACCATCCCAGACAAGCCC
AATAGCGAAGAGGAGATTGTCAACTTCGTGGAGGAGCACAGGAGATCAACCCTGAGGAAA
CTGAAGCCGGAGAGTATGTATGAGACCTGGGAGGATGATATGGATGGAATCCACATTGTG
GCCTTCGCAGAGGAAGCTGATCCTGATGGTTTCGAGTTCTTAGAGACTCTCAAGGCTGTG
GCCCAAGATAACACTGAAAACCCAGATCTTAGCATCATCTGGATTGACCCTGATGACTTC
CCCCTGCTGGTCCCATACTGGGAGAAGACGTTTGACATCGACTTGTCAGCCCCACAAATA
GGAGTCGTCAATGTTACTGATGCGGATAGCGTATGGATGGAAATGGACGATGAGGAGGAC
CTGCCTTCTGCTGAGGAGCTGGAGGACTGGCTGGAGGATGTCCTGGAGGGCGAGATCAAC
ACAGAGGACGATGACGATGATGATGATGACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 390 |
| Molecular Weight
| 44497.9 |
| Theoretical pI
| 3.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calsequestrin-1
MGPRAVPGLRLALLLLLVLGTPKSGVQGQEGLDFPEYDGVDRVINVNAKNYKNVFKKYEV
LALLYHEPPEDDKASQRQFEMEELILELAAQVLEDKGVGFGLVDSEKDAAVAKKLGLTEV
DSMYVFKGDEVIEYDGEFSADTIVEFLLDVLEDPVELIEGERELQAFENIEDEIKLIGYF
KSKDSEHYKAFEDAAEEFHPYIPFFATFDSKVAKKLTLKLNEIDFYEAFMEEPVTIPDKP
NSEEEIVNFVEEHRRSTLRKLKPESMYETWEDDMDGIHIVAFAEEADPDGFEFLETLKAV
AQDNTENPDLSIIWIDPDDFPLLVPYWEKTFDIDLSAPQIGVVNVTDADSVWMEMDDEED
LPSAEELEDWLEDVLEGEINTEDDDDDDDD
|
| External Links |
|---|
| GenBank ID Protein
| 189053808 |
| UniProtKB/Swiss-Prot ID
| P31415 |
| UniProtKB/Swiss-Prot Entry Name
| CASQ1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK313250 |
| GeneCard ID
| CASQ1 |
| GenAtlas ID
| CASQ1 |
| HGNC ID
| HGNC:1512 |
| References |
|---|
| General References
| Not Available |