| Identification |
|---|
| HMDB Protein ID
| CDBP02764 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calpain-9 |
| Description
| Not Available |
| Synonyms
|
- Digestive tract-specific calpain
- New calpain 4
- Protein CG36
- nCL-4
|
| Gene Name
| CAPN9 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium-dependent cysteine-type endopeptidase activity |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease |
| GO Classification
|
| Component |
| intracellular |
| cell part |
| Function |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium-dependent cysteine-type endopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| calcium ion binding |
| Process |
| proteolysis |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.11-q42.3 |
| SNPs
| CAPN9 |
| Gene Sequence
|
>2073 bp
ATGCCTTACCTCTACCGGGCCCCAGGGCCTCAGGCACACCCGGTTCCCAAGGACGCCCGG
ATCACCCACTCCTCAGGCCAGAGCTTTGAGCAAATGAGGCAGGAGTGCCTGCAGAGAGGC
ACCCTGTTTGAGGATGCAGACTTCCCAGCCAGCAATTCCTCCCTGTTCTACAGTGAGAGG
CCGCAGATCCCCTTTGTGTGGAAACGACCAGGGGAAATCGTGAAAAACCCAGAATTCATT
CTTGGAGGGGCCACCAGGACTGATATCTGCCAGGGAGAGCTGGGAGACTGCTGGCTATTA
GCCGCCATCGCCTCCCTTACGCTTAATCAAAAAGCACTGGCCAGAGTCATCCCCCAGGAC
CAAAGCTTTGGCCCTGGTTATGCCGGGATATTCCATTTCCAGTTCTGGCAGCACAGTGAG
TGGCTGGACGTGGTGATCGATGACCGCCTGCCCACCTTCAGGGACCGCTTGGTTTTCCTC
CACTCTGCCGACCACAACGAGTTCTGGAGCGCCTTGCTGGAAAAAGCCTACGCCAAGCTA
AATGGGAGCTATGAAGCTCTGAAGGGAGGCAGCGCCATCGAGGCCATGGAAGACTTCACT
GGGGGTGTGGCAGAGACCTTCCAAACTAAAGAGGCCCCCGAGAACTTCTATGAGATTCTA
GAGAAGGCTTTGAAGAGAGGCTCCCTGCTGGGCTGCTTCATTGATACCAGAAGTGCTGCA
GAATCTGAGGCCCGGACGCCGTTTGGTCTTATTAAGGGTCATGCCTACAGTGTAACGGGA
ATTGACCAGGTAAGCTTCCGAGGCCAGAGAATCGAGCTCATCCGAATCCGGAACCCTTGG
GGCCAGGTTGAGTGGAACGGGTCGTGGAGCGACAGTTCTCCGGAGTGGCGTTCTGTTGGT
CCAGCTGAGCAGAAGCGTCTGTGTCACACTGCTCTGGATGATGGGGAATTCTGGATGGCA
TTTAAGGACTTCAAGGCCCACTTTGATAAAGTGGAGATCTGCAACCTCACTCCCGATGCC
CTGGAGGAAGACGCGATCCACAAATGGGAGGTGACGGTCCATCAGGGAAGCTGGGTTCGC
GGCTCCACGGCTGGGGGCTGCCGCAATTTCCTGGATACCTTTTGGACCAATCCACAAATA
AAATTGTCTCTGACTGAGAAAGATGAGGGGCAGGAGGAGTGTAGTTTCCTTGTAGCCCTG
ATGCAGAAAGATAGAAGGAAACTCAAGAGATTTGGTGCCAATGTGCTGACAATCGGCTAT
GCCATTTATGAGTGCCCTGACAAAGACGAACACCTGAACAAAGACTTCTTCAGATACCAC
GCTTCTCGGGCCAGAAGCAAGACGTTCATCAACCTGAGAGAAGTCTCCGACCGGTTCAAG
CTGCCCCCTGGGGAGTACATCCTGATTCCCAGCACTTTTGAGCCCCACCAGGAAGCTGAT
TTCTGTCTGAGAATCTTTTCAGAGAAAAAAGCCATTACCCGGGATATGGATGGAAATGTA
GACATTGACCTTCCTGAGCCTCCAAAGCCAACTCCACCTGACCAGGAGACAGAGGAGGAG
CAGCGGTTTCGGGCTCTGTTTGAACAAGTCGCTGGTGAGGACATGGAGGTGACAGCAGAG
GAACTTGAGTATGTTTTAAATGCTGTGCTGCAAAAGAAAAAGGACATCAAATTCAAGAAG
CTAAGCCTGATCTCCTGTAAAAACATCATTTCCCTGATGGACACCAGCGGCAATGGGAAG
CTGGAGTTTGATGAATTCAAAGTGTTCTGGGACAAGCTGAAGCAGTGGATTAACCTTTTC
CTTCGGTTTGATGCTGACAAGTCCGGCACCATGTCTACCTATGAACTACGGACTGCACTG
AAAGCTGCAGGCTTTCAGCTGAGCAGCCACCTCCTGCAGCTGATTGTGCTCAGGTATGCG
GATGAGGAGCTCCAGCTGGACTTCGATGACTTCCTCAACTGCCTGGTCCGGCTGGAGAAT
GCGAGCCGGGTGTTCCAGGCTCTCAGTACAAAGAACAAGGAGTTCATTCATCTCAATATA
AATGAGTTCATCCATTTGACAATGAACATCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 690 |
| Molecular Weight
| 79095.8 |
| Theoretical pI
| 5.25 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain-9
MPYLYRAPGPQAHPVPKDARITHSSGQSFEQMRQECLQRGTLFEDADFPASNSSLFYSER
PQIPFVWKRPGEIVKNPEFILGGATRTDICQGELGDCWLLAAIASLTLNQKALARVIPQD
QSFGPGYAGIFHFQFWQHSEWLDVVIDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKL
NGSYEALKGGSAIEAMEDFTGGVAETFQTKEAPENFYEILEKALKRGSLLGCFIDTRSAA
ESEARTPFGLIKGHAYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVG
PAEQKRLCHTALDDGEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVR
GSTAGGCRNFLDTFWTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGY
AIYECPDKDEHLNKDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTFEPHQEAD
FCLRIFSEKKAITRDMDGNVDIDLPEPPKPTPPDQETEEEQRFRALFEQVAGEDMEVTAE
ELEYVLNAVLQKKKDIKFKKLSLISCKNIISLMDTSGNGKLEFDEFKVFWDKLKQWINLF
LRFDADKSGTMSTYELRTALKAAGFQLSSHLLQLIVLRYADEELQLDFDDFLNCLVRLEN
ASRVFQALSTKNKEFIHLNINEFIHLTMNI
|
| External Links |
|---|
| GenBank ID Protein
| 5729758 |
| UniProtKB/Swiss-Prot ID
| O14815 |
| UniProtKB/Swiss-Prot Entry Name
| CAN9_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006615.2 |
| GeneCard ID
| CAPN9 |
| GenAtlas ID
| CAPN9 |
| HGNC ID
| HGNC:1486 |
| References |
|---|
| General References
| Not Available |