Cannabis Compound Database: Showing Protein Calpain-8 (CDBP02763)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02763

Secondary Accession Numbers

Not Available

Name

Calpain-8

Description

Not Available

Synonyms

New calpain 2
Stomach-specific M-type calpain
nCL-2

Gene Name

CAPN8

Protein Type

Metal Binding

Biological Properties

General Function

Involved in calcium-dependent cysteine-type endopeptidase activity

Specific Function

Calcium-regulated non-lysosomal thiol-protease. Involved in membrane trafficking in the gastric surface mucus cells (pit cells) and may involve the membrane trafficking of mucus cells via interactions with coat protein. Proteolytically cleaves the beta- subunit of coatomer complex

GO Classification

Component
cell part
intracellular
Function
cation binding
metal ion binding
binding
catalytic activity
hydrolase activity
calcium-dependent cysteine-type endopeptidase activity
peptidase activity
peptidase activity, acting on l-amino acid peptides
calcium ion binding
endopeptidase activity
cysteine-type endopeptidase activity
ion binding
Process
metabolic process
macromolecule metabolic process
protein metabolic process
proteolysis

Cellular Location

Cytoplasm
Golgi apparatus

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1q41

SNPs

CAPN8

Gene Sequence

>2112 bp
ATGGCAGCCCAGGCAGCTGGTGTATCTAGGCAGCGGGCAGCCACTCAAGGTCTTGGCTCC
AACCAAAACGCTTTGAAGTACTTGGGCCAGGATTTCAAGACCCTGAGGCAACAGTGCTTG
GACTCAGGGGTCCTATTTAAGGACCCTGAGTTCCCAGCATGTCCATCAGCTTTGGGCTAC
AAGGATCTTGGACCAGGCTCTCCGCAAACTCAAGGCATCATCTGGAAGCGGCCCACGGAG
TTGTGTCCCAGCCCTCAGTTTATCGTTGGTGGAGCCACGCGCACAGACATTTGTCAGGGT
GGTCTAGGTGACTGCTGGCTTCTGGCTGCCATTGCCTCCCTGACCCTGAATGAAGAGCTG
CTTTACCGGGTGGTCCCCAGGGACCAGGACTTCCAGGAGAACTATGCGGGAATCTTTCAC
TTTCAGTTCTGGCAGTACGGAGAGTGGGTGGAGGTGGTCATTGACGACAGGCTGCCCACC
AAGAATGGACAGCTGCTCTTCCTACACTCGGAACAAGGCAATGAATTCTGGAGTGCCCTG
CTGGAGAAAGCCTATGCCAAGCTTAATGGTTGTTATGAGGCTCTCGCTGGAGGTTCCACA
GTGGAGGGGTTTGAGGATTTCACAGGTGGCATCTCTGAGTTTTATGACCTGAAGAAACCA
CCAGCCAATCTATATCAGATCATCCGGAAGGCCCTCTGTGCGGGGTCTCTGCTGGGCTGC
TCCATTGATGTCTCCAGTGCAGCCGAAGCCGAAGCCATCACCAGCCAGAAGCTGGTTAAG
AGTCATGCGTACTCTGTCACTGGAGTCGAAGAGGTGAATTTCCAGGGCCATCCAGAGAAG
CTGATCAGACTCAGGAATCCATGGGGTGAAGTGGAGTGGTCGGGAGCCTGGAGCGATGAT
GCACCAGAGTGGAATCACATAGACCCCCGGCGGAAGGAAGAACTGGACAAGAAAGTTGAG
GATGGAGAATTCTGGATGTCACTTTCAGATTTCGTGAGGCAGTTCTCTCGGTTGGAGATC
TGCAACCTGTCCCCGGACTCTCTGAGTAGCGAGGAGGTGCACAAATGGAACCTGGTCCTG
TTCAACGGCCACTGGACCCGGGGCTCCACAGCTGGGGGCTGCCAGAACTACCCAGCCACG
TACTGGACCAATCCCCAGTTCAAAATCCGTTTGGATGAAGTGGATGAGGACCAGGAGGAG
AGCATCGGTGAACCCTGCTGTACAGTGCTGCTGGGCCTGATGCAGAAAAATCGCAGGTGG
CGGAAGCGGATAGGACAAGGCATGCTTAGCATCGGCTATGCCGTCTACCAGGTTCCCAAG
GAGCTGGAGAGTCACACGGACGCACACTTGGGCCGGGATTTCTTCCTGGCCTACCAGCCC
TCAGCCCGCACCAGCACCTACGTCAACCTGCGGGAGGTCTCTGGCCGGGCCCGGCTGCCC
CCTGGGGAGTACCTGGTGGTGCCATCCACATTTGAACCCTTCAAAGACGGCGAGTTCTGC
TTGAGAGTGTTCTCAGAGAAGAAGGCCCAGGCCCTAGAAATTGGGGATGTGGTAGCTGGA
AACCCATATGAGCCACATCCCAGTGAGGTGGATCAGGAAGATGACCAGTTCAGGAGGCTG
TTTGAGAAGTTGGCAGGGAAGGATTCTGAGATTACTGCCAATGCACTCAAGATACTTTTG
AATGAGGCGTTTTCCAAGAGAACAGACATAAAATTCGATGGATTCAACATCAACACTTGC
AGGGAAATGATCAGTCTGTTGGATAGCAATGGAACGGGCACTTTGGGGGCGGTGGAATTC
AAGACGCTCTGGCTGAAGATTCAGAAGTATCTGGAGATCTATTGGGAAACTGATTATAAC
CACTCGGGCACCATCGATGCCCACGAGATGAGGACAGCCCTCAGGAAGGCAGGTTTCACC
CTCAACAGCCAGGTGCAGCAGACCATTGCCCTGCGGTATGCGTGCAGCAAGCTCGGCATC
AACTTTGACAGCTTCGTGGCTTGTATGATCCGCCTGGAGACCCTCTTCAAACTATTCAGC
CTTCTGGACGAAGACAAGGATGGCATGGTTCAGCTCTCTCTGGCCGAGTGGCTGTGCTGC
GTGTTGGTCTGA

Protein Properties

Number of Residues

703

Molecular Weight

79143.8

Theoretical pI

4.86

Pfam Domain Function

Calpain_III (PF01067 )
Peptidase_C2 (PF00648 )

Signals

["None"]

Transmembrane Regions

["None"]

Protein Sequence

>Calpain-8
MAAQAAGVSRQRAATQGLGSNQNALKYLGQDFKTLRQQCLDSGVLFKDPEFPACPSALGY
KDLGPGSPQTQGIIWKRPTELCPSPQFIVGGATRTDICQGGLGDCWLLAAIASLTLNEEL
LYRVVPRDQDFQENYAGIFHFQFWQYGEWVEVVIDDRLPTKNGQLLFLHSEQGNEFWSAL
LEKAYAKLNGCYEALAGGSTVEGFEDFTGGISEFYDLKKPPANLYQIIRKALCAGSLLGC
SIDVSSAAEAEAITSQKLVKSHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDD
APEWNHIDPRRKEELDKKVEDGEFWMSLSDFVRQFSRLEICNLSPDSLSSEEVHKWNLVL
FNGHWTRGSTAGGCQNYPATYWTNPQFKIRLDEVDEDQEESIGEPCCTVLLGLMQKNRRW
RKRIGQGMLSIGYAVYQVPKELESHTDAHLGRDFFLAYQPSARTSTYVNLREVSGRARLP
PGEYLVVPSTFEPFKDGEFCLRVFSEKKAQALEIGDVVAGNPYEPHPSEVDQEDDQFRRL
FEKLAGKDSEITANALKILLNEAFSKRTDIKFDGFNINTCREMISLLDSNGTGTLGAVEF
KTLWLKIQKYLEIYWETDYNHSGTIDAHEMRTALRKAGFTLNSQVQQTIALRYACSKLGI
NFDSFVACMIRLETLFKLFSLLDEDKDGMVQLSLAEWLCCVLV

External Links

GenBank ID Protein

221554549

UniProtKB/Swiss-Prot ID

A6NHC0

UniProtKB/Swiss-Prot Entry Name

CAN8_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_001143962.1

GeneCard ID