| Identification |
|---|
| HMDB Protein ID
| CDBP02758 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calpain-14 |
| Description
| Not Available |
| Synonyms
|
- CANP 14
- Calcium-activated neutral proteinase 14
|
| Gene Name
| CAPN14 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium-dependent cysteine-type endopeptidase activity |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease |
| GO Classification
|
| Component |
| intracellular |
| cell part |
| Function |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium-dependent cysteine-type endopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| calcium ion binding |
| Process |
| proteolysis |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p23.1-p21 |
| SNPs
| CAPN14 |
| Gene Sequence
|
>2055 bp
ATGTCTCTGTGGCCACCTTTCCGATGCAGATGGAAGCTGGCGCCAAGGTACTCTAGGAGG
GCGTCTCCACAGCAACCCCAACAGGACTTTGAGGCCCTGCTGGCAGAGTGCCTGAGGAAT
GGCTGCCTCTTTGAAGACACCAGCTTCCCGGCCACCCTGAGCTCCATCGGCAGTGGCTCC
CTGCTGCAGAAGCTGCCACCCCGCCTGCAGTGGAAGAGGCCCCCGGAGCTGCACAGCAAT
CCCCAGTTTTATTTTGCCAAGGCCAAAAGGCTGGATCTGTGCCAGGGGATAGTAGGAGAC
TGCTGGTTCTTGGCTGCTTTGCAAGCTCTGGCCTTGCACCAGGACATCCTGAGCCGGGTT
GTTCCCCTGAATCAGAGTTTCACTGAGAAGTATGCTGGCATCTTCCGGTTCTGGTTCTGG
CACTATGGGAACTGGGTTCCTGTGGTGATCGATGACCGTCTGCCTGTGAATGAGGCTGGC
CAGCTGGTCTTTGTCTCCTCCACCTATAAGAACTTGTTCTGGGGAGCACTTCTGGAAAAG
GCCTATGCCAAGCTCTCTGGTTCCTATGAAGACTTGCAGTCAGGACAGGTGTCTGAAGCC
CTTGTAGACTTCACTGGAGGGGTGACAATGACCATCAACCTGGCAGAAGCCCATGGCAAC
CTCTGGGACATCCTCATCGAAGCCACCTACAACAGAACCCTCATTGGCTGCCAGACCCAC
TCAGGGGAGAAGATTCTGGAGAATGGGCTGGTGGAAGGCCATGCCTATACTCTCACAGGA
ATCAGGAAGGTGACCTGCAAACATAGACCTGAATATCTCGTCAAGCTACGGAACCCCTGG
GGAAAGGTGGAATGGAAAGGAGACTGGAGTGACAGTTCAAGTAAATGGGAGCTGCTGAGC
CCCAAGGAGAAGATTCTGCTTCTGAGGAAAGACAATGACGGAGAATTCTGGATGACGCTG
CAGGACTTTAAAACACATTTCGTGCTCCTGGTTATCTGTAAACTGACCCCAGGCCTGTTG
AGCCAGGAGGCGGCCCAGAAGTGGACGTACACCATGCGGGAGGGGAGATGGGAGAAGCGG
AGCACAGCTGGTGGCCAGAGGCAGTTGCTGCAGGACACATTTTGGAAGAACCCGCAGTTC
CTGCTGTCTGTCTGGAGGCCCGAGGAGGGCAGGAGATCCCTGAGGCCCTGCAGCGTGCTG
GTGTCCCTGCTCCAGAAGCCCAGGCACAGGTGCCGCAAGCGGAAGCCTCTCCTCGCCATT
GGCTTCTACCTGTATAGGATGAACAAGTACCATGATGACCAGAGGAGACTGCCCCCTGAG
TTCTTCCAGAGAAACACTCCTCTGAGCCAGCCTGATAGGTTTCTCAAGGAGAAAGAAGTG
AGTCAGGAGCTGTGTCTGGAACCAGGGACGTACCTCATCGTGCCCTGCATATTGGAGGCC
CACCAGAAGTCAGAGTTCGTCCTCAGGGTCTTCTCCAGGAAGCACATCTTTTATGAAATT
GGCAGCAATTCTGGTGTCGTCTTCTCAAAGGAGATAGAAGACCAAAATGAAAGGCAGGAT
GAATTCTTCACCAAATTCTTTGAAAAGCATCCAGAGATTAATGCAGTTCAACTTCAGAAC
CTCCTGAACCAGATGACCTGGTCAAGTCTGGGGAGCAGACAGCCCTTCTTTAGCCTGGAA
GCCTGCCAGGGGATCCTGGCCTTACTGGACCTTAATGCATCAGGTACTATGAGCATCCAG
GAATTCAGGGACCTGTGGAAGCAGCTGAAGCTCTCTCAGAAGGTTTTCCACAAGCAAGAC
CGTGGGTCAGGATACCTGAACTGGGAGCAGCTGCACGCTGCCATGAGGGAGGCAGGAATC
ATGCTCAGTGATGACGTCTGTCAGCTGATGCTCATCCGCTACGGCGGCCCCCGCCTCCAG
ATGGACTTTGTCAGTTTCATCCACTTGATGCTGCGTGTAGAGAACATGGAGGATGTCTTC
CAAAACTTAACCCAAGATGGCAAAGGGATATACCTCCAGAAGCCAGAGTGGATGATGATG
GCACTGTACTCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 684 |
| Molecular Weight
| 79567.1 |
| Theoretical pI
| 8.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain-14
MSLWPPFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIGSGS
LLQKLPPRLQWKRPPELHSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQDILSRV
VPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWGALLEK
AYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGNLWDILIEATYNRTLIGCQTH
SGEKILENGLVEGHAYTLTGIRKVTCKHRPEYLVKLRNPWGKVEWKGDWSDSSSKWELLS
PKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKLTPGLLSQEAAQKWTYTMREGRWEKR
STAGGQRQLLQDTFWKNPQFLLSVWRPEEGRRSLRPCSVLVSLLQKPRHRCRKRKPLLAI
GFYLYRMNKYHDDQRRLPPEFFQRNTPLSQPDRFLKEKEVSQELCLEPGTYLIVPCILEA
HQKSEFVLRVFSRKHIFYEIGSNSGVVFSKEIEDQNERQDEFFTKFFEKHPEINAVQLQN
LLNQMTWSSLGSRQPFFSLEACQGILALLDLNASGTMSIQEFRDLWKQLKLSQKVFHKQD
RGSGYLNWEQLHAAMREAGIMLSDDVCQLMLIRYGGPRLQMDFVSFIHLMLRVENMEDVF
QNLTQDGKGIYLQKPEWMMMALYS
|
| External Links |
|---|
| GenBank ID Protein
| 223468608 |
| UniProtKB/Swiss-Prot ID
| A8MX76 |
| UniProtKB/Swiss-Prot Entry Name
| CAN14_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001145122.1 |
| GeneCard ID
| CAPN14 |
| GenAtlas ID
| CAPN14 |
| HGNC ID
| HGNC:16664 |
| References |
|---|
| General References
| Not Available |