| Identification |
|---|
| HMDB Protein ID
| CDBP02756 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calpain-12 |
| Description
| Not Available |
| Synonyms
|
- CANP 12
- Calcium-activated neutral proteinase 12
|
| Gene Name
| CAPN12 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium-dependent cysteine-type endopeptidase activity |
| Specific Function
| Calcium-regulated non-lysosomal thiol-protease |
| GO Classification
|
| Component |
| cell part |
| intracellular |
| Function |
| endopeptidase activity |
| cysteine-type endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| calcium-dependent cysteine-type endopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| calcium ion binding |
| Process |
| protein metabolic process |
| proteolysis |
| metabolic process |
| macromolecule metabolic process |
|
| Cellular Location
|
- Cytoplasmic
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.2 |
| SNPs
| CAPN12 |
| Gene Sequence
|
>2160 bp
ATGGCATCCAGCAGTGGGAGGGTCACCATCCAGCTCGTGGATGAGGAGGCTGGGGTCGGA
GCCGGGCGCCTGCAGCTTTTTCGGGGCCAGAGCTATGAGGCAATTCGGGCAGCCTGCCTG
GATTCGGGGATCCTGTTCCGCGACCCTTACTTCCCTGCTGGCCCTGATGCCCTTGGCTAT
GACCAGCTGGGGCCGGACTCGGAGAAGGCCAAAGGCGTGAAATGGATGAGGCCCCATGAG
TTCTGTGCTGAGCCGAAGTTCATCTGTGAAGACATGAGCCGCACAGACGTGTGTCAGGGG
AGCCTGGGTAACTGCTGGTTCCTTGCAGCCGCCGCCTCCCTTACTCTGTATCCCCGGCTC
CTGCGCCGGGTGGTCCCTCCTGGACAGGATTTCCAGCATGGCTACGCAGGCGTCTTCCAC
TTCCAGCTCTGGCAGTTTGGCCGCTGGATGGACGTCGTGGTGGATGACAGGCTGCCCGTG
CGTGAGGGGAAGCTGATGTTCGTGCGCTCGGAACAGCGGAATGAGTTCTGGGCCCCACTC
CTGGAGAAGGCCTACGCCAAGCTCCACGGCTCCTATGAGGTGATGCGGGGCGGCCACATG
AATGAGGCTTTTGTGGATTTCACAGGCGGCGTGGGCGAGGTGCTCTATCTGAGACAAAAC
AGCATGGGGCTGTTCTCTGCCCTGCGCCATGCCCTGGCCAAGGAGTCCCTCGTGGGCGCC
ACTGCCCTGAGTGATCGGGGTGAGTACCGCACAGAAGAGGGCCTGGTAAAGGGACACGCG
TATTCCATCACGGGCACACACAAGGTGTTCCTGGGCTTCACCAAGGTGCGGCTGCTGCGG
CTGCGGAACCCATGGGGCTGCGTGGAGTGGACGGGGGCCTGGAGCGACAGCTGCCCACGC
TGGGACACACTCCCCACCGAGTGCCGCGATGCCCTGCTGGTGAAAAAGGAGGATGGCGAG
TTCTGGATGGAGCTGCGGGACTTCCTCCTCCATTTCGACACCGTGCAGATCTGCTCGCTG
AGCCCGGAGGTGCTGGGCCCCAGCCCGGAGGGGGGCGGCTGGCACGTCCACACCTTCCAA
GGCCGCTGGGTGCGTGGCTTCAACTCCGGCGGGAGCCAGCCTAATGCTGAAACCTTCTGG
ACCAATCCTCAGTTCCGTTTAACGCTGCTGGAGCCTGATGAGGAGGATGACGAGGATGAG
GAAGGGCCCTGGGGGGGCTGGGGGGCTGCAGGGGCACGGGGCCCAGCGCGGGGGGGCCGC
ACGCCCAAGTGCACGGTCCTTCTGTCCCTCATCCAGCGCAACCGGCGGCGCCTGAGAGCC
AAGGGCCTCACTTACCTCACCGTTGGCTTCCACGTGTTCCAGATTCCAGAGGAGCTGCTG
GGCCTCTGGGATTCCCCGCGCAGCCATGCGCTCCTGCCCCGGCTGCTGCGCGCCGACCGC
TCGCCCCTCAGCGCCCGCCGCGACGTGACCCGCCGCTGCTGCCTGCGTCCAGGCCACTAC
CTGGTGGTGCCGAGCACCGCCCACGCCGGCGACGAGGCTGACTTCACTCTGCGTGTCTTC
TCCGAGCGCCGCCACACGGCCGTGGAGATCGACGACGTGATCAGCGCAGACCTGCAGTCT
CTCCAGGGCCCCTACCTGCCCCTGGAGCTGGGGTTGGAGCAGCTGTTTCAGGAGCTGGCT
GGAGAGGAGGAAGAACTCAATGCCTCTCAGCTCCAGGCCTTACTAAGCATTGCCCTGGAG
CCTGCCAGGGCCCATACCTCCACCCCCAGAGAGATCGGGCTCAGGACCTGTGAGCAGCTG
CTGCAGTGTTTCGGGCATGGGCAAAGCCTGGCCTTACACCACTTCCAGCAGCTCTGGGGC
TACCTCCTGGAGTGGCAGGCCATATTCAACAAGTTCGATGAGGACACCTCTGGAACCATG
AACTCCTACGAGCTGAGGCTGGCACTGAATGCAGCAGGCTTCCACCTGAACAACCAGCTG
ACCCAGACCCTCACCAGCCGCTACCGGGATAGCCGTCTGCGTGTGGACTTCGAGCGGTTC
GTGTCCTGTGTGGCCCACCTCACCTGCATCTTCTGCCACTGCAGCCAGCACCTGGATGGG
GGTGAGGGGGTCATCTGCCTGACCCACAGACAGTGGATGGAGGTGGCCACCTTCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 719 |
| Molecular Weight
| 81036.2 |
| Theoretical pI
| 6.34 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calpain-12
MASSSGRVTIQLVDEEAGVGAGRLQLFRGQSYEAIRAACLDSGILFRDPYFPAGPDALGY
DQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRL
LRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPL
LEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGA
TALSDRGEYRTEEGLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPR
WDTLPTECRDALLVKKEDGEFWMELRDFLLHFDTVQICSLSPEVLGPSPEGGGWHVHTFQ
GRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGPWGGWGAAGARGPARGGR
TPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRSHALLPRLLRADR
SPLSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHTAVEIDDVISADLQS
LQGPYLPLELGLEQLFQELAGEEEELNASQLQALLSIALEPARAHTSTPREIGLRTCEQL
LQCFGHGQSLALHHFQQLWGYLLEWQAIFNKFDEDTSGTMNSYELRLALNAAGFHLNNQL
TQTLTSRYRDSRLRVDFERFVSCVAHLTCIFCHCSQHLDGGEGVICLTHRQWMEVATFS
|
| External Links |
|---|
| GenBank ID Protein
| 34534289 |
| UniProtKB/Swiss-Prot ID
| Q6ZSI9 |
| UniProtKB/Swiss-Prot Entry Name
| CAN12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK127398 |
| GeneCard ID
| CAPN12 |
| GenAtlas ID
| CAPN12 |
| HGNC ID
| HGNC:13249 |
| References |
|---|
| General References
| Not Available |