| Identification |
|---|
| HMDB Protein ID
| CDBP02725 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-18 |
| Description
| Not Available |
| Synonyms
|
- Cadherin-14
|
| Gene Name
| CDH18 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| calcium ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5p14.3 |
| SNPs
| CDH18 |
| Gene Sequence
|
>2373 bp
ATGAAAATTACTAGCACATCTTGCATCTGTCCAGTCCTAGTGTGTCTCTGTTTTGTGCAG
AGGTGTTATGGAACTGCTCACCACAGCTCCATCAAGGTGATGAGAAACCAAACCAAACAC
ATTGAAGGTGAAACCGAAGTCCATCATCGTCCCAAAAGGGGATGGGTATGGAATCAGTTC
TTTGTTTTAGAAGAACATATGGGACCAGATCCTCAGTATGTTGGAAAGCTGCACTCCAAT
TCTGACAAAGGTGATGGATCTGTCAAGTACATCCTTACTGGAGAGGGTGCTGGGACTATA
TTTATCATTGACGATACCACGGGTGATATCCACTCAACAAAAAGCCTAGACAGAGAGCAG
AAGACCCACTATGTGCTTCATGCTCAAGCTATTGATAGACGTACAAACAAACCTCTTGAG
CCTGAATCCGAGTTCATCATCAAAGTGCAAGACATCAATGACAACGCTCCAAAATTCACA
GATGGACCATACATTGTTACTGTGCCTGAAATGTCAGATATGGGTACCTCTGTTCTACAG
GTGACAGCTACTGATGCAGATGACCCTACCTATGGAAACAGCGCTCGGGTGGTTTACAGC
ATTCTCCAGGGACAACCCTACTTCTCCGTCGACCCTAAAACAGGAGTTATTAGAACGGCC
TTACATAACATGGACAGAGAAGCCAGAGAACATTACTCCGTAGTCATTCAAGCCAAAGAC
ATGGCTGGGCAAGTTGGAGGGCTTTCAGGATCTACAACAGTCAACATCACCTTAACCGAT
GTCAATGACAACCCACCACGCTTTCCTCAAAAACACTATCAGCTATATGTTCCTGAGTCA
GCTCAAGTTGGTTCAGCTGTTGGGAAAATCAAGGCAAATGATGCTGACACTGGCTCAAAT
GCTGACATGACCTACTCCATCATAAATGGTGATGGCATGGGAATATTCTCAATCTCCACT
GACAAAGAGACCAGAGAAGGAATCCTTTCTTTAAAGAAGCCACTGAACTATGAGAAAAAG
AAGTCATATACCCTCAACATAGAAGGAGCAAATACACATCTTGATTTTCGCTTTTCTCAC
TTGGGTCCTTTTAAAGATGCTACTATGCTGAAGATCATTGTTGGGGATGTAGATGAACCA
CCACTATTTTCCATGCCTTCCTACCTCATGGAAGTCTACGAAAATGCCAAGATTGGGACC
GTCGTTGGTACAGTTTTGGCACAAGATCCTGACAGTACTAACAGCTTAGTAAGATACTTC
ATCAACTACAATGTTGAAGACGACAGATTTTTCAACATTGATGCCAATACTGGGACCATT
AGGACTACAAAGGTTCTCGACAGAGAAGAAACTCCATGGTACAACATCACAGTCACTGCT
TCAGAAATTGATAATCCTGATTTGCTGAGCCATGTCACAGTGGGTATTAGAGTTCTGGAT
GTCAATGACAATCCACCCGAACTTGCCAGGGAATATGATATTATTGTATGTGAAAATTCT
AAGCCTGGCCAGGTTATTCATACCATCAGTGCCACTGATAAAGATGATTTTGCCAATGGA
CCAAGGTTTAACTTCTTTCTTGATGAACGCCTGCCTGTAAATCCAAACTTCACTCTGAAG
GACAATGAAGATAACACAGCCAGCATTCTGACAAGGCGGAGGAGATTTAGTCGAACTGTT
CAGGATGTGTATTATCTGCCCATTATGATCTCTGATGGTGGAATCCCCTCTCTCAGCAGC
AGCAGCACCCTCACCATCAGGGTTTGTGCATGCGAGAGAGATGGGCGTGTGCGGACCTGC
CATGCAGAAGCCTTCCTGTCCTCGGCTGGTTTGAGTACAGGAGCCTTAATCGCTATTCTT
CTCTGTGTTCTCATTCTCCTGGCAATTGTGGTACTTTTTATCACCCTGAGGCGCAGCAAA
AAAGAGCCCTTGATCATTTCAGAAGAGGATGTACGGGAGAACGTGGTCACCTATGATGAT
GAAGGAGGCGGAGAGGAAGACACAGAGGCCTTTGACATCACAGCCTTGAGGAATCCTTCT
GCTGCTGAGGAGCTCAAGTACCGGAGGGATATCAGACCTGAAGTGAAGCTCACTCCCAGA
CACCAGACATCATCCACCCTGGAAAGCATAGATGTTCAGGAATTTATTAAGCAAAGACTG
GCAGAAGCAGACCTAGACCCTAGCGTTCCCCCTTATGACTCTCTTCAGACTTATGCCTAT
GAGGGTCAGAGATCAGAAGCTGGGTCTATCAGCTCGCTGGATTCAGCAACGACACAATCA
GACCAGGATTATCACTACCTTGGAGACTGGGGACCCGAGTTTAAAAAGTTAGCTGAACTC
TATGGAGAAATAGAATCTGAAAGAACAACTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 790 |
| Molecular Weight
| 88071.9 |
| Theoretical pI
| 4.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-18
MKITSTSCICPVLVCLCFVQRCYGTAHHSSIKVMRNQTKHIEGETEVHHRPKRGWVWNQF
FVLEEHMGPDPQYVGKLHSNSDKGDGSVKYILTGEGAGTIFIIDDTTGDIHSTKSLDREQ
KTHYVLHAQAIDRRTNKPLEPESEFIIKVQDINDNAPKFTDGPYIVTVPEMSDMGTSVLQ
VTATDADDPTYGNSARVVYSILQGQPYFSVDPKTGVIRTALHNMDREAREHYSVVIQAKD
MAGQVGGLSGSTTVNITLTDVNDNPPRFPQKHYQLYVPESAQVGSAVGKIKANDADTGSN
ADMTYSIINGDGMGIFSISTDKETREGILSLKKPLNYEKKKSYTLNIEGANTHLDFRFSH
LGPFKDATMLKIIVGDVDEPPLFSMPSYLMEVYENAKIGTVVGTVLAQDPDSTNSLVRYF
INYNVEDDRFFNIDANTGTIRTTKVLDREETPWYNITVTASEIDNPDLLSHVTVGIRVLD
VNDNPPELAREYDIIVCENSKPGQVIHTISATDKDDFANGPRFNFFLDERLPVNPNFTLK
DNEDNTASILTRRRRFSRTVQDVYYLPIMISDGGIPSLSSSSTLTIRVCACERDGRVRTC
HAEAFLSSAGLSTGALIAILLCVLILLAIVVLFITLRRSKKEPLIISEEDVRENVVTYDD
EGGGEEDTEAFDITALRNPSAAEELKYRRDIRPEVKLTPRHQTSSTLESIDVQEFIKQRL
AEADLDPSVPPYDSLQTYAYEGQRSEAGSISSLDSATTQSDQDYHYLGDWGPEFKKLAEL
YGEIESERTT
|
| External Links |
|---|
| GenBank ID Protein
| 158260117 |
| UniProtKB/Swiss-Prot ID
| Q13634 |
| UniProtKB/Swiss-Prot Entry Name
| CAD18_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK289547 |
| GeneCard ID
| CDH18 |
| GenAtlas ID
| CDH18 |
| HGNC ID
| HGNC:1757 |
| References |
|---|
| General References
| Not Available |