| Identification |
|---|
| HMDB Protein ID
| CDBP02721 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cadherin-12 |
| Description
| Not Available |
| Synonyms
|
- BR-cadherin
- Brain cadherin
- N-cadherin 2
- Neural type cadherin 2
|
| Gene Name
| CDH12 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5p14.3 |
| SNPs
| CDH12 |
| Gene Sequence
|
>2385 bp
ATGCTTACAAGGAACTGTTTATCCCTGCTTCTCTGGGTTCTGTTTGATGGAGGTCTCCTA
ACACCACTACAACCACAGCCACAGCAGACTTTAGCCACAGAGCCAAGAGAAAATGTTATC
CATCTGCCAGGACAACGGTCACATTTCCAACGTGTTAAACGTGGCTGGGTATGGAATCAA
TTTTTTGTGCTGGAAGAATACGTGGGCTCCGAGCCTCAGTATGTGGGAAAGCTCCATTCC
GACTTAGACAAGGGAGAGGGCACTGTGAAATACACCCTCTCAGGAGATGGCGCTGGCACC
GTTTTTACCATTGATGAAACCACAGGGGACATTCATGCAATAAGGAGCCTAGATAGAGAA
GAGAAACCTTTCTACACTCTTCGTGCTCAGGCTGTGGACATAGAAACCAGAAAGCCCCTG
GAGCCTGAATCAGAATTCATCATCAAAGTGCAGGATATTAATGATAATGAGCCAAAGTTT
TTGGATGGACCTTATGTTGCTACTGTTCCAGAAATGTCTCCTGTGGGTGCATATGTACTC
CAGGTCAAGGCCACAGATGCAGATGACCCGACCTATGGAAACAGTGCCAGAGTCGTTTAC
AGCATTCTTCAGGGACAACCTTATTTCTCTATTGATCCCAAGACAGGTGTTATTAGAACA
GCTTTGCCAAACATGGACAGAGAAGTCAAAGAACAATATCAAGTACTCATCCAAGCCAAG
GATATGGGAGGACAGCTTGGAGGATTAGCCGGAACAACAATAGTCAACATCACTCTCACC
GATGTCAATGACAATCCACCTCGATTCCCCAAAAGCATCTTCCACTTGAAAGTTCCTGAG
TCTTCCCCTATTGGTTCAGCTATTGGAAGAATAAGAGCTGTGGATCCTGATTTTGGACAA
AATGCAGAAATTGAATACAATATTGTTCCAGGAGATGGGGGAAATTTGTTTGACATCGTC
ACAGATGAGGATACACAAGAGGGAGTCATCAAATTGAAAAAGCCTTTAGATTTTGAAACA
AAGAAGGCATACACTTTCAAAGTTGAGGCTTCCAACCTTCACCTTGACCACCGGTTTCAC
TCGGCGGGCCCTTTCAAAGACACAGCTACGGTGAAGATCAGCGTGCTGGACGTAGATGAG
CCACCGGTTTTCAGCAAGCCGCTCTACACCATGGAGGTTTATGAAGACACTCCGGTAGGG
ACCATCATTGGCGCTGTCACTGCTCAAGACCTGGATGTAGGCAGCAGTGCTGTTAGGTAC
TTCATAGATTGGAAGAGTGATGGGGACAGCTACTTTACAATAGATGGAAATGAAGGAACC
ATCGCCACTAATGAATTACTAGACAGAGAAAGCACTGCGCAGTATAATTTCTCCATAATT
GCGAGTAAAGTTAGTAACCCTTTATTGACCAGCAAAGTCAATATACTGATTAATGTCTTA
GATGTAAATGAATTTCCTCCAGAAATATCTGTGCCATATGAGACAGCCGTGTGTGAAAAT
GCCAAGCCAGGACAGATAATTCAGATAGTCAGTGCTGCAGACCGAGATCTTTCACCTGCT
GGGCAACAATTCTCCTTTAGATTATCACCTGAGGCTGCTATCAAACCAAATTTTACAGTT
CGTGACTTCAGAAACAACACAGCGGGGATTGAAACCCGAAGAAATGGATACAGCCGCAGG
CAGCAAGAGTTGTATTTCCTCCCTGTTGTAATAGAAGACAGCAGCTACCCTGTCCAGAGC
AGCACAAACACAATGACTATTCGAGTCTGTAGATGTGACTCTGATGGCACCATCCTGTCT
TGTAATGTGGAAGCAATTTTTCTACCTGTAGGACTTAGCACTGGGGCGTTGATTGCAATT
CTACTATGCATTGTTATACTCTTAGCCATAGTTGTACTGTATGTAGCACTGCGAAGGCAG
AAGAAAAAAGACACCCTGATGACCTCTAAAGAAGACATCAGAGACAACGTCATCCATTAC
GATGATGAAGGAGGTGGGGAGGAAGATACCCAGGCTTTCGACATCGGGGCTCTGAGAAAC
CCAAAAGTGATTGAGGAGAACAAAATTCGCAGGGATATAAAACCAGACTCTCTCTGTTTA
CCTCGTCAGAGACCACCCATGGAAGATAACACAGACATAAGGGATTTCATTCATCAAAGG
CTACAGGAAAATGACGTGGACCCAACTGCCCCACCATACGATTCACTGGCCACATATGCC
TACGAAGGGAGTGGGTCCGTGGCAGAGTCCCTCAGCTCTATAGACTCTCTCACCACAGAA
GCCGACCAGGACTATGACTATCTGACAGACTGGGGACCCCGCTTTAAAGTCTTGGCAGAC
ATGTTTGGCGAAGAAGAGAGTTATAACCCTGATAAAGTCACTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 794 |
| Molecular Weight
| 88331.5 |
| Theoretical pI
| 4.4 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cadherin-12
MLTRNCLSLLLWVLFDGGLLTPLQPQPQQTLATEPRENVIHLPGQRSHFQRVKRGWVWNQ
FFVLEEYVGSEPQYVGKLHSDLDKGEGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDRE
EKPFYTLRAQAVDIETRKPLEPESEFIIKVQDINDNEPKFLDGPYVATVPEMSPVGAYVL
QVKATDADDPTYGNSARVVYSILQGQPYFSIDPKTGVIRTALPNMDREVKEQYQVLIQAK
DMGGQLGGLAGTTIVNITLTDVNDNPPRFPKSIFHLKVPESSPIGSAIGRIRAVDPDFGQ
NAEIEYNIVPGDGGNLFDIVTDEDTQEGVIKLKKPLDFETKKAYTFKVEASNLHLDHRFH
SAGPFKDTATVKISVLDVDEPPVFSKPLYTMEVYEDTPVGTIIGAVTAQDLDVGSSAVRY
FIDWKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVL
DVNEFPPEISVPYETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAIKPNFTV
RDFRNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVCRCDSDGTILS
CNVEAIFLPVGLSTGALIAILLCIVILLAIVVLYVALRRQKKKDTLMTSKEDIRDNVIHY
DDEGGGEEDTQAFDIGALRNPKVIEENKIRRDIKPDSLCLPRQRPPMEDNTDIRDFIHQR
LQENDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLAD
MFGEEESYNPDKVT
|
| External Links |
|---|
| GenBank ID Protein
| 189054555 |
| UniProtKB/Swiss-Prot ID
| P55289 |
| UniProtKB/Swiss-Prot Entry Name
| CAD12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK314800 |
| GeneCard ID
| CDH12 |
| GenAtlas ID
| CDH12 |
| HGNC ID
| HGNC:1751 |
| References |
|---|
| General References
| Not Available |