| Identification |
|---|
| HMDB Protein ID
| CDBP02704 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calcineurin-binding protein cabin-1 |
| Description
| Not Available |
| Synonyms
|
- CAIN
- Calcineurin inhibitor
|
| Gene Name
| CABIN1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals |
| GO Classification
|
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 22q11.23 |
| SNPs
| CABIN1 |
| Gene Sequence
|
>6663 bp
ATGATTCGAATTGCAGCCTTAAATGCCAGCTCCACCATTGAGGATGATCATGAAGGAAGC
TTTAAAAGTCACAAAACCCAGACAAAGGAGGCTCAGGAAGCAGAGGCTTTTGCATTGTAC
CACAAGGCCCTTGATCTGCAGAAACATGACCGGTTTGAGGAGTCTGCCAAAGCCTACCAT
GAGCTCTTGGAGGCGAGCCTGCTGCGGGAGGCAGTTTCATCCGGTGATGAGAAAGAGGGG
TTGAAACACCCTGGGCTGATACTGAAATATTCCACTTATAAGAACTTGGCCCAGCTGGCA
GCCCAGCGGGAGGATCTGGAGACAGCCATGGAGTTCTACTTAGAGGCAGTGATGCTGGAC
TCCACAGATGTCAACCTCTGGTATAAGATTGGACATGTGGCCCTGAGGCTCATCCGGATC
CCCCTGGCTCGCCATGCTTTTGAGGAAGGGCTGCGGTGCAATCCTGACCACTGGCCCTGT
TTGGATAACCTAATCACTGTCCTGTACACCCTCAGTGATTACACAACATGTCTGTACTTC
ATCTGCAAAGCTTTGGAGAAGGATTGCCGGTACAGCAAAGGGCTGGTCCTCAAGGAGAAG
ATTTTTGAGGAGCAGCCTTGTCTCCGGAAGGACTCTCTCAGAATGTTCCTCAAATGTGAC
ATGTCGATTCACGATGTTTCGGTGAGTGCAGCTGAGACACAGGCGATTGTAGATGAGGCC
TTGGGGCTGCGAAAAAAGAGGCAAGCGCTGATTGTGCGGGAGAAGGAGCCGGACCTGAAA
CTTGTGCAGCCCATTCCTTTCTTCACCTGGAAGTGCCTCGGAGAGAGCTTGCTGGCCATG
TACAATCATCTCACCACCTGTGAGCCCCCACGTCCCAGCCTTGGCAAAAGGATTGATTTG
TCGGACTACCAGGACCCCAGCCAGCCTCTTGAGTCCTCCATGGTGGTGACGCCAGTTAAC
GTGATCCAGCCAAGCACTGTCAGCACCAACCCAGCTGTGGCTGTCGCCGAGCCTGTGGTC
TCCTACACCTCTGTGGCTACAACCAGCTTCCCACTGCACAGTCCTGGTCTGTTGGAGACA
GGCGCTCCTGTGGGTGATATTTCTGGGGGAGATAAATCCAAGAAAGGGGTAAAACGGAAG
AAGATTTCAGAAGAGAGTGGAGAAACAGCAAAGCGGCGGTCTGCCCGTGTCCGAAACACC
AAGTGCAAAAAAGAAGAGAAAGTAGACTTCCAGGAGCTTCTGATGAAGTTCTTGCCGTCC
AGGTTAAGAAAGCTGGACCCTGAGGAGGAAGATGATTCCTTTAATAACTATGAAGTCCAG
TCAGAAGCCAAACTGGAAAGCTTCCCAAGCATTGGGCCTCAAAGGCTGTCATTTGACTCA
GCCACATTCATGGAATCTGAAAAGCAGGACGTGCATGAGTTCCTGCTGGAGAACCTAACC
AACGGGGGCATCCTGGAGCTGATGATGCGCTACCTGAAAGCCATGGGCCACAAGTTCTTG
GTAAGGTGGCCTCCAGGCTTGGCGGAGGTCGTGCTCAGCGTCTACCACAGCTGGAGGAGG
CACAGCACCAGCCTGCCCAACCCGCTGCTGAGGGACTGCAGCAACAAGCACATCAAGGAC
ATGATGCTGATGTCTCTCTCCTGCATGGAACTCCAGCTGGACCAGTGGCTGCTGACCAAA
GGCAGAAGCTCTGCAGTGTCTCCTCGGAACTGTCCTGCTGGTATGGTGAATGGCAGATTT
GGACCTGACTTCCCAGGGACCCACTGCCTGGGTGACCTCCTACAGCTGTCATTTGCCTCG
TCCCAGCGCGACCTGTTCGAGGATGGTTGGCTGGAGTTTGTGGTCCGTGTTTACTGGCTG
AAGGCTCGCTTCCTGGCGCTGCAGGGAGACATGGAGCAGGCCCTGGAGAACTATGACATC
TGCACAGAAATGCTCCAGAGTTCCACCGCCATCCAGGTGGAGGCAGGGGCTGAACGAAGA
GACATTGTCATCCGGCTGCCCAACCTCCATAATGACTCTGTGGTTTCCCTGGAGGAGATT
GATAAGAACCTGAAGTCGCTGGAGCGGTGCCAGTCCCTGGAGGAGATTCAGCGGCTGTAT
GAAGCAGGCGACTACAAGGCTGTTGTGCATCTGCTCCGCCCCACTTTGTGCACCAGTGGG
TTTGACCGGGCCAAACACCTGGAGTTTATGACTTCCATTCCTGAGAGGCCAGCCCAGCTG
CTTCTTCTGCAGGACTCCTTGCTCCGGCTGAAGGACTATCGGCAGTGTTTTGAGTGTTCC
GATGTGGCTCTGAACGAGGCTGTCCAGCAGATGGTGAACTCAGGTGAGGCTGCCGCCAAG
GAGGAGTGGGTGGCCACAGTGACCCAACTGCTGATGGGCATCGAGCAGGCCCTCTCTGCG
GACAGCAGTGGTAGCATCCTGAAGGTATCATCCTCCACCACTGGCCTTGTGCGGCTCACC
AACAACCTCATCCAGGTCATTGACTGCAGCATGGCTGTGCAGGAGGAGGCCAAGGAGCCC
CACGTCTCTTCAGTGCTACCCTGGATCATTCTACACCGGATCATCTGGCAGGAGGAAGAC
ACCTTCCATTCTCTGTGCCACCAGCAGCAGCTCCAAAACCCAGCGGAGGAAGGGATGTCA
GAGACGCCCATGCTCCCATCCTCCCTCATGCTGCTGAACACAGCCCACGAGTATTTGGGC
AGAAGGTCCTGGTGCTGCAATTCAGATGGGGCTCTGCTGCGATTCTATGTGCGAGTACTC
CAGAAGGAACTGGCTGCATCCACCTCTGAAGACACGCACCCTTACAAGGAGGAGCTGGAG
ACAGCCTTGGAGCAGTGCTTCTACTGCCTGTACAGCTTCCCCAGCAAGAAGAGTAAGGCC
AGGTACCTGGAGGAACACTCGGCCCAGCAGGTGGATCTTATATGGGAGGATGCACTGTTC
ATGTTTGAGTATTTTAAGCCCAAGACCCTTCCTGAATTTGACAGCTATAAGACCAGCACC
GTGTCTGCTGACTTGGCCAACCTACTGAAGAGAATTGCCACCATTGTGCCTCGCACAGAG
AGGCCAGCCCTTAGCCTGGACAAAGTCTCTGCCTACATTGAGGGAACTTCAACTGAGGTA
CCCTGCCTCCCAGAGGGGGCTGACCCCTCCCCTCCAGTGGTGAACGAGCTTTACTACCTC
CTGGCTGATTATCATTTCAAAAACAAGGAGCAGTCCAAGGCCATCAAGTTCTACATGCAT
GACATCTGCATCTGCCCCAATAGGTTTGATTCCTGGGCAGGCATGGCTCTGGCCCGGGCC
AGCCGCATTCAGGACAAGCTGAACTCCAATGAGCTGAAGAGTGATGGGCCCATTTGGAAG
CATGCCACGCCCGTCTTGAACTGCTTCCGTCGGGCCCTGGAGATTGACAGCTCCAACTTG
TCCCTATGGATTGAGTATGGCACCATGTCCTATGCCTTGCACTCATTCGCCTCACGTCAA
TTGAAGCAGTGGAGAGGCGAGCTGCCCCCTGAGCTCGTGCAGCAGATGGAGGGCCGGCGC
GACAGCATGCTAGAGACAGCCAAGCACTGTTTCACATCAGCAGCCCGCTGCGAGGGTGAT
GGTGACGAGGAGGAGTGGCTCATCCACTACATGCTGGGCAAGGTGGCTGAGAAGCAGCAG
CAGCCACCCACCGTTTACTTGCTGCACTACAGGCAGGCTGGCCACTACCTGCACGAGGAG
GCTGCCCGCTACCCCAAGAAGATCCACTACCACAACCCACCTGAGCTGGCCATGGAGGCC
CTGGAGGTGTACTTTCGGCTCCATGCTTCCATCCTGAAGCTCCTGGGGAAGCCCGATTCT
GGGGTTGGTGCAGAGGTCCTGGTCAACTTTATGAAGGAGGCTGCAGAAGGACCCTTTGCC
AGGGGCGAGGAGAAGAACACACCCAAAGCTTCAGAAAAGGAGAAGGCCTGCCTGGTGGAC
GAGGACTCCCACTCTTCAGCTGGGACACTGCCGGGCCCCGGAGCCTCCCTCCCCTCCTCC
TCTGGCCCAGGTCTGACATCCCCACCTTACACAGCCACTCCGATTGACCACGATTACGTC
AAATGTAAAAAACCCCACCAGCAGGCAACGCCGGACGACCGAAGCCAGGACAGCACAGCC
GTAGCACTCTCAGACTCTAGCTCAACGCAGGACTTCTTTAATGAGCCCACCAGCTTACTG
GAAGGCTCCAGGAAATCCTACACAGAGAAGAGGCTGCCCATTCTCAGTTCCCAAGCAGGA
GCGACGGGTAAAGATCTTCAGGGGGCCACAGAAGAAAGAGGAAAAAACGAGGAGTCATTG
GAGAGTACAGAAGGCTTCCGGGCTGCAGAGCAAGGTGTCCAGAAGCCTGCTGCAGAAACC
CCAGCCTCTGCTTGCATCCCTGGCAAGCCCTCAGCATCCACACCCACCCTGTGGGATGGG
AAGAAGAGAGGGGACCTCCCAGGGGAGCCAGTGGCCTTCCCCCAGGGGCTGCCGGCTGGT
GCTGAGGAGCAGCGGCAGTTTCTCACAGAGCAGTGCATCGCCTCCTTCCGCCTGTGCCTG
AGCCGCTTCCCCCAGCACTATAAGAGTCTCTACCGTCTGGCCTTCCTCTACACCTACAGC
AAGACCCACCGGAACCTCCAGTGGGCCCGCGACGTGTTGCTAGGCAGCAGTATCCCGTGG
CAACAACTGCAGCACATGCCGGCACAGGGGCTCTTCTGCGAGAGGAACAAGACCAATTTC
TTCAACGGCATCTGGCGGATCCCCGTGGACGAGATTGACCGGCCGGGCAGCTTTGCCTGG
CACATGAACCGCTCCATCGTGCTGCTGCTCAAGGTGCTGGCCCAGCTGCGGGACCACAGC
ACCCTGCTGAAGGTGTCCTCCATGCTTCAGCGGACCCCAGACCAGGGCAAGAAGTATCTG
CGAGATGCTGACCGCCAGGTCCTGGCGCAGCGGGCCTTCATCCTCACTGTGAAGGTGCTC
GAAGACACGCTGAGCGAGCTCGCAGAGGGGTCAGAACGCCCAGGGCCCAAGGTCTGTGGC
CTCCCCGGAGCCAGGATGACCACCGATGTCTCACACAAGGCCAGTCCTGAGGATGGCCAG
GAGGGCCTCCCCCAGCCGAAGAAGCCCCCTCTGGCTGATGGCTCAGGGCCAGGGCCCGAG
CCAGGAGGCAAAGTGGGCCTCCTCAACCACCGGCCTGTGGCCATGGATGCAGGAGACAGT
GCAGACCAAAGCGGGGAGCGGAAGGATAAAGAGAGCCCACGGGCAGGGCCCACTGAGCCC
ATGGACACGAGTGAGGCCACTGTTTGCCACTCAGACTTGGAGCGGACACCACCCCTGCTG
CCAGGTCGCCCCGCAAGGGACCGGGGCCCCGAGAGCCGGCCCACTGAGCTGTCCCTGGAG
GAGCTGAGCATCAGTGCCCGGCAGCAGCCCACCCCGCTCACCCCAGCCCAGCCAGCCCCC
GCCCCCGCCCCCGCCACCACCACAGGGACCAGGGCAGGGGGCCACCCGGAGGAGCCGCTC
TCCCGGCTCAGCCGCAAGAGGAAGCTCCTGGAGGACACAGAGTCAGGCAAGACACTTCTG
TTGGATGCCTACCGTGTGTGGCAGCAGGGCCAGAAGGGTGTGGCCTATGACCTGGGCCGT
GTGGAGAGGATCATGTCGGAGACCTACATGCTCATCAAGCAGGTGGATGAGGAGGCTGCG
CTGGAGCAGGCTGTGAAGTTCTGCCAGGTCCATCTTGGGGCTGCCGCCCAGAGACAGGCC
TCGGGGGACACCCCCACCACTCCAAAGCACCCCAAAGACAGCCGAGAGAACTTCTTTCCT
GTGACAGTGGTGCCCACAGCCCCTGACCCTGTGCCAGCTGACTCTGTCCAGCGGCCCAGT
GATGCTCACACCAAGCCTCGCCCTGCACTAGCTGCCGCCACAACTATTATCACCTGCCCT
CCGTCAGCATCAGCTTCCACCCTGGACCAGTCCAAGGACCCTGGGCCTCCCCGGCCACAC
AGGCCTGAAGCTACCCCCAGCATGGCCTCTCTGGGCCCAGAGGGAGAAGAGCTGGCGAGA
GTGGCAGAGGGCACCAGCTTCCCGCCTCAGGAGCCACGGCACAGTCCGCAGGTGAAGATG
GCCCCCACAAGTTCCCCGGCAGAGCCACACTGCTGGCCGGCAGAGGCTGCCCTGGGCACA
GGCGCTGAGCCCACCTGCAGCCAGGAGGGGAAACTGAGGCCTGAGCCGAGAAGGGATGGG
GAGGCTCAGGAGGCTGCGAGTGAGACTCAGCCCCTGAGCTCTCCCCCAACAGCTGCCAGC
TCCAAGGCCCCCAGCAGTGGGAGTGCCCAGCCACCAGAGGGTCACCCAGGCAAGCCTGAG
CCCAGCCGGGCTAAGTCCCGCCCCCTGCCCAACATGCCAAAGCTGGTCATCCCCTCCGCC
GCCACCAAGTTCCCCCCTGAGATCACCGTCACGCCACCCACCCCAACCCTGCTCTCCCCC
AAAGGCAGCATCTCGGAGGAGACCAAGCAGAAGCTGAAGTCAGCCATCCTTTCTGCCCAG
TCTGCTGCCAACGTGAGGAAGGAGAGCCTATGCCAGCCAGCCCTGGAGGTCCTGGAGACA
TCCAGCCAGGAGTCCTCGCTGGAGAGCGAGACAGACGAGGACGACGACTACATGGACATT
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 2220 |
| Molecular Weight
| 246349.5 |
| Theoretical pI
| 5.9 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calcineurin-binding protein cabin-1
MIRIAALNASSTIEDDHEGSFKSHKTQTKEAQEAEAFALYHKALDLQKHDRFEESAKAYH
ELLEASLLREAVSSGDEKEGLKHPGLILKYSTYKNLAQLAAQREDLETAMEFYLEAVMLD
STDVNLWYKIGHVALRLIRIPLARHAFEEGLRCNPDHWPCLDNLITVLYTLSDYTTCLYF
ICKALEKDCRYSKGLVLKEKIFEEQPCLRKDSLRMFLKCDMSIHDVSVSAAETQAIVDEA
LGLRKKRQALIVREKEPDLKLVQPIPFFTWKCLGESLLAMYNHLTTCEPPRPSLGKRIDL
SDYQDPSQPLESSMVVTPVNVIQPSTVSTNPAVAVAEPVVSYTSVATTSFPLHSPGLLET
GAPVGDISGGDKSKKGVKRKKISEESGETAKRRSARVRNTKCKKEEKVDFQELLMKFLPS
RLRKLDPEEEDDSFNNYEVQSEAKLESFPSIGPQRLSFDSATFMESEKQDVHEFLLENLT
NGGILELMMRYLKAMGHKFLVRWPPGLAEVVLSVYHSWRRHSTSLPNPLLRDCSNKHIKD
MMLMSLSCMELQLDQWLLTKGRSSAVSPRNCPAGMVNGRFGPDFPGTHCLGDLLQLSFAS
SQRDLFEDGWLEFVVRVYWLKARFLALQGDMEQALENYDICTEMLQSSTAIQVEAGAERR
DIVIRLPNLHNDSVVSLEEIDKNLKSLERCQSLEEIQRLYEAGDYKAVVHLLRPTLCTSG
FDRAKHLEFMTSIPERPAQLLLLQDSLLRLKDYRQCFECSDVALNEAVQQMVNSGEAAAK
EEWVATVTQLLMGIEQALSADSSGSILKVSSSTTGLVRLTNNLIQVIDCSMAVQEEAKEP
HVSSVLPWIILHRIIWQEEDTFHSLCHQQQLQNPAEEGMSETPMLPSSLMLLNTAHEYLG
RRSWCCNSDGALLRFYVRVLQKELAASTSEDTHPYKEELETALEQCFYCLYSFPSKKSKA
RYLEEHSAQQVDLIWEDALFMFEYFKPKTLPEFDSYKTSTVSADLANLLKRIATIVPRTE
RPALSLDKVSAYIEGTSTEVPCLPEGADPSPPVVNELYYLLADYHFKNKEQSKAIKFYMH
DICICPNRFDSWAGMALARASRIQDKLNSNELKSDGPIWKHATPVLNCFRRALEIDSSNL
SLWIEYGTMSYALHSFASRQLKQWRGELPPELVQQMEGRRDSMLETAKHCFTSAARCEGD
GDEEEWLIHYMLGKVAEKQQQPPTVYLLHYRQAGHYLHEEAARYPKKIHYHNPPELAMEA
LEVYFRLHASILKLLGKPDSGVGAEVLVNFMKEAAEGPFARGEEKNTPKASEKEKACLVD
EDSHSSAGTLPGPGASLPSSSGPGLTSPPYTATPIDHDYVKCKKPHQQATPDDRSQDSTA
VALSDSSSTQDFFNEPTSLLEGSRKSYTEKRLPILSSQAGATGKDLQGATEERGKNEESL
ESTEGFRAAEQGVQKPAAETPASACIPGKPSASTPTLWDGKKRGDLPGEPVAFPQGLPAG
AEEQRQFLTEQCIASFRLCLSRFPQHYKSLYRLAFLYTYSKTHRNLQWARDVLLGSSIPW
QQLQHMPAQGLFCERNKTNFFNGIWRIPVDEIDRPGSFAWHMNRSIVLLLKVLAQLRDHS
TLLKVSSMLQRTPDQGKKYLRDADRQVLAQRAFILTVKVLEDTLSELAEGSERPGPKVCG
LPGARMTTDVSHKASPEDGQEGLPQPKKPPLADGSGPGPEPGGKVGLLNHRPVAMDAGDS
ADQSGERKDKESPRAGPTEPMDTSEATVCHSDLERTPPLLPGRPARDRGPESRPTELSLE
ELSISARQQPTPLTPAQPAPAPAPATTTGTRAGGHPEEPLSRLSRKRKLLEDTESGKTLL
LDAYRVWQQGQKGVAYDLGRVERIMSETYMLIKQVDEEAALEQAVKFCQVHLGAAAQRQA
SGDTPTTPKHPKDSRENFFPVTVVPTAPDPVPADSVQRPSDAHTKPRPALAAATTIITCP
PSASASTLDQSKDPGPPRPHRPEATPSMASLGPEGEELARVAEGTSFPPQEPRHSPQVKM
APTSSPAEPHCWPAEAALGTGAEPTCSQEGKLRPEPRRDGEAQEAASETQPLSSPPTAAS
SKAPSSGSAQPPEGHPGKPEPSRAKSRPLPNMPKLVIPSAATKFPPEITVTPPTPTLLSP
KGSISEETKQKLKSAILSAQSAANVRKESLCQPALEVLETSSQESSLESETDEDDDYMDI
|
| External Links |
|---|
| GenBank ID Protein
| 6912458 |
| UniProtKB/Swiss-Prot ID
| Q9Y6J0 |
| UniProtKB/Swiss-Prot Entry Name
| CABIN_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_012295.2 |
| GeneCard ID
| CABIN1 |
| GenAtlas ID
| CABIN1 |
| HGNC ID
| HGNC:24187 |
| References |
|---|
| General References
| Not Available |