| Identification |
|---|
| HMDB Protein ID
| CDBP02697 |
| Secondary Accession Numbers
| Not Available |
| Name
| Coiled-coil and C2 domain-containing protein 1A |
| Description
| Not Available |
| Synonyms
|
- FRE under dual repression-binding protein 1
- Five repressor element under dual repression-binding protein 1
- Freud-1
- Putative NF-kappa-B-activating protein 023N
|
| Gene Name
| CC2D1A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Lipid transport and metabolism |
| Specific Function
| Transcription factor that binds specifically to the FRE (five repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.12 |
| SNPs
| CC2D1A |
| Gene Sequence
|
>2856 bp
ATGCACAAGAGGAAAGGACCCCCGGGACCCCCGGGCAGAGGCGCCGCGGCCGCCCGCCAG
CTGGGCCTGCTGGTTGACCTCTCCCCAGATGGCCTGATGATCCCTGAGGACGGGGCTAAC
GATGAAGAACTGGAGGCTGAGTTCTTGGCTTTGGTCGGGGGCCAGCCCCCAGCCCTGGAG
AAGCTCAAAGGCAAAGGTCCCTTGCCGATGGAGGCCATTGAGAAGATGGCCAGCCTGTGC
ATGAGAGACCCGGATGAGGATGAGGAGGAGGGGACGGATGAGGACGACTTGGAGGCTGAT
GATGACCTGCTGGCGGAGCTAAATGAGGTCCTTGGAGAGGAGCAGAAGGCTTCAGAGACC
CCACCTCCTGTGGCCCAGCCGAAGCCTGAGGCCCCTCATCCGGGGCTGGAGACCACCTTG
CAGGAGAGGCTGGCGCTCTATCAGACAGCAATTGAAAGCGCCAGACAAGCTGGAGACAGC
GCCAAGATGCGGCGCTACGATCGGGGGCTTAAAACACTGGAAAACCTGCTCGCCTCCATC
CGTAAGGGCAATGCCATTGACGAAGCGGACATCCCGCCGCCAGTGGCCATAGGAAAAGGC
CCGGCGTCCACGCCTACCTACAGCCCTGCACCCACCCAGCCGGCCCCTAGAATCGCGTCA
GCCCCAGAGCCCAGGGTCACCCTGGAGGGACCTTCTGCCACCGCCCCAGCCTCATCTCCA
GGCTTGGCTAAGCCCCAGATGCCCCCAGGTCCCTGCAGCCCTGGCCCTCTGGCCCAGTTG
CAGAGCCGCCAGCGCGACTACAAGCTGGCTGCCCTCCACGCCAAGCAGCAGGGAGATACC
ACTGCTGCCGCTAGACACTTCCGCGTGGCTAAGAGCTTTGATGCTGTCTTGGAGGCCCTG
AGCCGGGGTGAGCCCGTGGACCTCTCCTGCCTGCCCCCTCCACCCGACCAGCTGCCCCCA
GACCCACCGTCACCACCGTCGCAGCCTCCGACCCCCGCTACGGCGCCCTCCACAACAGAG
GTGCCCCCACCCCCGAGGACCCTGCTGGAGGCGCTGGAGCAGCGGATGGAGCGGTACCAG
GTGGCCGCAGCCCAGGCCAAGAGCAAGGGGGACCAGCGGAAAGCTCGAATGCACGAGCGC
ATCGTCAAGCAATACCAAGATGCCATCCGAGCCCACAAGGCTGGCCGAGCCGTGGATGTC
GCTGAATTGCCCGTGCCCCCAGGCTTCCCCCCAATCCAGGGCCTGGAGGCCACCAAGCCC
ACCCAGCAGAGTCTGGTGGGTGTCCTGGAGACTGCCATGAAGCTGGCCAACCAGGATGAA
GGCCCAGAGGATGAAGAGGATGAGGTGCCTAAGAAGCAGAACAGCCCTGTGGCCCCCACA
GCCCAGCCCAAAGCCCCACCCTCAAGAACTCCCCAGTCGGGATCAGCCCCAACAGCCAAA
GCGCCCCCCAAAGCCACATCCACCAGAGCCCAGCAGCAGCTGGCCTTCCTAGAGGGCCGC
AAGAAGCAGCTCCTGCAGGCCGCACTGCGAGCCAAGCAGAAAAACGACGTGGAGGGTGCC
AAGATGCACCTGCGCCAAGCCAAGGGACTGGAGCCTATGCTGGAGGCCTCGCGCAATGGG
CTGCCTGTGGACATCACCAAGGTGCCGCCTGCCCCTGTCAACAAGGACGACTTTGCCCTG
GTCCAGCGGCCTGGCCCGGGTCTGTCTCAGGAGGCCGCCCGGCGCTATGGTGAACTCACC
AAGCTCATACGGCAGCAGCACGAGATGTGCCTGAACCACTCAAACCAATTCACCCAGCTG
GGCAACATCACTGAAACCACCAAGTTTGAAAAGTTGGCGGAGGACTGTAAGCGGAGCATG
GACATTCTGAAGCAAGCCTTCGTCCGGGGTCTCCCCACGCCCACCGCCCGCTTTGAGCAA
AGGACCTTCAGCGTCATCAAGATCTTCCCTGACCTCAGCAGCAACGACATGCTCCTCTTC
ATCGTGAAGGGCATCAACTTGCCCACACCCCCAGGACTGTCCCCTGGCGATCTGGATGTC
TTTGTTCGGTTTGACTTCCCCTATCCCAACGTGGAAGAAGCTCAGAAAGACAAGACCAGT
GTGATCAAGAACACAGACTCCCCTGAGTTCAAGGAGCAGTTCAAACTCTGCATCAACCGC
AGCCACCGTGGCTTCCGAAGGGCCATCCAGACCAAGGGCATCAAGTTCGAAGTGGTTCAC
AAGGGGGGGCTGTTCAAGACTGACCGGGTGCTGGGGACAGCCCAGCTGAAGCTGGATGCA
CTGGAGATAGCATGTGAGGTCCGGGAGATCCTTGAGGTCCTGGATGGTCGCCGGCCCACA
GGGGGGCGACTGGAGGTAATGGTCCGGATTCGGGAGCCACTGACAGCCCAGCAGTTGGAG
ACGACGACAGAGAGGTGGCTAGTCATTGACCCTGTGCCGGCAGCTGTGCCCACACAGGTT
GCTGGGCCCGAAGGGAAGGCCCCTCCTGTGCCTGCCCCTGCAAGGGAGCCAGGGAACAGA
TCAGCCCGGCCCCTGCATAGCCTCAGTGTGCTGGCGTTTGACCAAGAGCGTCTGGAGCGG
AAGATCCTGGCCCTCAGGCAGGCGCGGCGGCCGGTGCCCCCAGAAGTGGCCCAGCAGTAC
CAGGACATCATGCAACGCAGCCAGTGGCAGAGGGCACAGCTGGAGCAGGGGGGTGTGGGC
ATCCGACGGGAATACACAGCCCAGCTGGAGCGGCAGCTGCAGTTCTACACGGAGGCTGCC
CGGCGCCTGGGCAACGATGGCAGCAGGGATGCTGCAAAGGAGGCGCTCTATAGGCGGAAT
CTGGTAGGGAGTGAGCTGCAGCGGCTCCGCAGGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 951 |
| Molecular Weight
| 104061.5 |
| Theoretical pI
| 8.26 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Coiled-coil and C2 domain-containing protein 1A
MHKRKGPPGPPGRGAAAARQLGLLVDLSPDGLMIPEDGANDEELEAEFLALVGGQPPALE
KLKGKGPLPMEAIEKMASLCMRDPDEDEEEGTDEDDLEADDDLLAELNEVLGEEQKASET
PPPVAQPKPEAPHPGLETTLQERLALYQTAIESARQAGDSAKMRRYDRGLKTLENLLASI
RKGNAIDEADIPPPVAIGKGPASTPTYSPAPTQPAPRIASAPEPRVTLEGPSATAPASSP
GLAKPQMPPGPCSPGPLAQLQSRQRDYKLAALHAKQQGDTTAAARHFRVAKSFDAVLEAL
SRGEPVDLSCLPPPPDQLPPDPPSPPSQPPTPATAPSTTEVPPPPRTLLEALEQRMERYQ
VAAAQAKSKGDQRKARMHERIVKQYQDAIRAHKAGRAVDVAELPVPPGFPPIQGLEATKP
TQQSLVGVLETAMKLANQDEGPEDEEDEVPKKQNSPVAPTAQPKAPPSRTPQSGSAPTAK
APPKATSTRAQQQLAFLEGRKKQLLQAALRAKQKNDVEGAKMHLRQAKGLEPMLEASRNG
LPVDITKVPPAPVNKDDFALVQRPGPGLSQEAARRYGELTKLIRQQHEMCLNHSNQFTQL
GNITETTKFEKLAEDCKRSMDILKQAFVRGLPTPTARFEQRTFSVIKIFPDLSSNDMLLF
IVKGINLPTPPGLSPGDLDVFVRFDFPYPNVEEAQKDKTSVIKNTDSPEFKEQFKLCINR
SHRGFRRAIQTKGIKFEVVHKGGLFKTDRVLGTAQLKLDALEIACEVREILEVLDGRRPT
GGRLEVMVRIREPLTAQQLETTTERWLVIDPVPAAVPTQVAGPKGKAPPVPAPARESGNR
SARPLHSLSVLAFDQERLERKILALRQARRPVPPEVAQQYQDIMQRSQWQRAQLEQGGVG
IRREYAAQLERQLQFYTEAARRLGNDGSRDAAKEALYRRNLVESELQRLRR
|
| External Links |
|---|
| GenBank ID Protein
| 31455459 |
| UniProtKB/Swiss-Prot ID
| Q6P1N0 |
| UniProtKB/Swiss-Prot Entry Name
| C2D1A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB097002 |
| GeneCard ID
| CC2D1A |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |