| Identification |
|---|
| HMDB Protein ID
| CDBP02688 |
| Secondary Accession Numbers
| Not Available |
| Name
| Bone morphogenetic protein 8B |
| Description
| Not Available |
| Synonyms
|
- BMP-8
- BMP-8B
- OP-2
- Osteogenic protein 2
|
| Gene Name
| BMP8B |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in growth factor activity |
| Specific Function
| Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis |
| GO Classification
|
| Component |
| extracellular region |
| Function |
| binding |
| protein binding |
| receptor binding |
| growth factor activity |
| Process |
| growth |
|
| Cellular Location
|
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1p35-p32 |
| SNPs
| BMP8B |
| Gene Sequence
|
>1209 bp
ATGACCGCGCTCCCCGGCCCGCTCTGGCTCCTGGGCCTGGCGCTATGCGCGCTGGGCGGG
GGCGGCCCCGGCCTGCGACCCCCGCCCGGCTGTCCCCAGCGACGTCTGGGCGCGCGCGAG
CGCCGGGACGTGCAGCGCGAGATCCTGGCGGTGCTCGGGCTGCCTGGGCGGCCCCGGCCC
CGCGCGCCACCCGCCGCCTCCCGGCTGCCCGCGTCCGCGCCGCTCTTCATGCTGGACCTG
TACCACGCCATGGCCGGCGACGACGACGAGGACGGCGCGCCCGCGGAGCGGCGCCTGGGC
CGCGCCGACCTGGTCATGAGCTTCGTTAACATGGTGGAGCGAGACCGTGCCCTGGGCCAC
CAGGAGCCCCATTGGAAGGAGTTCCGCTTTGACCTGACCCAGATCCCGGCTGGGGAGGCG
GTCACAGCTGCGGAGTTCCGGATTTACAAGGTGCCCAGCATCCACCTGCTCAACAGGACC
CTCCACGTCAGCATGTTCCAGGTGGTCCAGGAGCAGTCCAACAGGGAGTCTGACTTGTTC
TTTTTGGATCTTCAGACGCTCCGAGCTGGAGACGAGGGCTGGCTGGTGCTGGATGTCACA
GCAGCCAGTGACTGCTGGTTGCTGAAGCGTCACAAGGACCTGGGACTCCGCCTCTATGTG
GAGACTGAGGACGGGCACAGCGTGGATCCTGGCCTGGCCGGCCTGCTGGGTCAACGGGCC
CCACGCTCCCAACAGCCTTTCGTGGTCACTTTCTTCAGGGCCAGTCCGAGTCCCATCCGC
ACCCCTCGGGCAGTGAGGCCACTGAGGAGGAGGCAGCCGAAGAAAAGCAACGAGCTGCCG
CAGGCCAACCGACTCCCAGGGATCTTTGATGACGTCCACGGCTCCCACGGCCGGCAGGTC
TGCCGTCGGCACGAGCTCTACGTCAGCTTCCAGGACCTCGGCTGGCTGGACTGGGTCATC
GCTCCCCAAGGCTACTCGGCCTATTACTGTGAGGGGGAGTGCTCCTTCCCACTGGACTCC
TGCATGAATGCCACCAACCACGCCATCCTGCAGTCCCTGGTGCACCTGATGATGCCAGAC
GCAGTCCCCAAGGCGTGCTGTGCACCCACCAAGCTGAGCGCCACCTCTGTGCTCTACTAT
GACAGCAGCAACAATGTCATCCTGCGCAAGCACCGCAACATGGTGGTCAAGGCCTGCGGC
TGCCACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 402 |
| Molecular Weight
| 44768.0 |
| Theoretical pI
| 8.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Bone morphogenetic protein 8B
MTALPGPLWLLGLALCALGGGGPGLRPPPGCPQRRLGARERRDVQREILAVLGLPGRPRP
RAPPAASRLPASAPLFMLDLYHAMAGDDDEDGAPAERRLGRADLVMSFVNMVERDRALGH
QEPHWKEFRFDLTQIPAGEAVTAAEFRIYKVPSIHLLNRTLHVSMFQVVQEQSNRESDLF
FLDLQTLRAGDEGWLVLDVTAASDCWLLKRHKDLGLRLYVETEDGHSVDPGLAGLLGQRA
PRSQQPFVVTFFRASPSPIRTPRAVRPLRRRQPKKSNELPQANRLPGIFDDVHGSHGRQV
CRRHELYVSFQDLGWLDWVIAPQGYSAYYCEGECSFPLDSCMNATNHAILQSLVHLMMPD
AVPKACCAPTKLSATSVLYYDSSNNVILRKHRNMVVKACGCH
|
| External Links |
|---|
| GenBank ID Protein
| 7018292 |
| UniProtKB/Swiss-Prot ID
| P34820 |
| UniProtKB/Swiss-Prot Entry Name
| BMP8B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AL033527 |
| GeneCard ID
| BMP8B |
| GenAtlas ID
| BMP8B |
| HGNC ID
| HGNC:1075 |
| References |
|---|
| General References
| Not Available |