| Identification |
|---|
| HMDB Protein ID
| CDBP02661 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anoctamin-8 |
| Description
| Not Available |
| Synonyms
|
- Transmembrane protein 16H
|
| Gene Name
| ANO8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| May act as a calcium-activated chloride channel |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p13.11 |
| SNPs
| ANO8 |
| Gene Sequence
|
>3699 bp
ATGGCCGAGGCCGCCTCCGGCGCCGGGGGCACGTCCCTGGAGGGCGAGCGTGGCAAGAGG
CCCCCGCCGGAGGGCGAGCCTGCAGCCCCGGCGTCCGGAGTTCTGGATAAGCTTTTCGGA
AAGCGGCTCCTGCAGGCTGGTCGCTACCTGGTGTCCCACAAGGCGTGGATGAAGACGGTG
CCTACAGAGAACTGCGACGTGCTGATGACCTTCCCAGACACGACCGATGACCACACGCTG
CTATGGCTGCTGAACCACATCCGCGTGGGCATTCCCGAGCTCATCGTGCAAGTCCGCCAC
CACCGCCACACGCGTGCCTACGCCTTCTTTGTCACCGCCACGTATGAGAGCCTACTCCGA
GGGGCCGACGAGCTGGGTCTGCGCAAAGCAGTGAAGGCCGAGTTTGGCGGGGGCACCCGC
GGCTTCTCCTGCGAGGAGGACTTTATCTATGAGAATGTGGAGAGCGAGCTACGCTTCTTC
ACCTCCCAGGAACGCCAGAGCATCATCCGCTTCTGGCTGCAGAATTTGCGTGCCAAGCAG
GGAGAAGCACTCCACAACGTGCGCTTCCTGGAGGACCAGCCAATCATCCCGGAGCTGGCA
GCACGTGGGATCATCCAGCAGGTGTTCCCTGTCCACGAGCAGCGTATTCTGAACCGCCTC
ATGAAGTCATGGGTGCAGGCCGTGTGTGAAAACCAGCCTCTAGATGACATCTGTGATTAC
TTTGGTGTGAAAATTGCCATGTACTTCGCCTGGCTGGGCTTCTACACGTCGGCTATGGTA
TACCCAGCTGTCTTCGGGTCTGTCCTGTACACATTCACAGAGGCTGATCAGACAAGCCGG
GATGTTTCCTGCGTGGTCTTTGCCCTCTTCAACGTGATCTGGTCGACGCTGTTCCTAGAG
GAATGGAAGCGGAGAGGGGCTGAGCTGGCATATAAGTGGGGGACGCTGGACTCACCTGGG
GAAGCCGTGGAGGAGCCACGCCCCCAGTTCAGGGGCGTGCGACGTATCAGCCCCATCACG
CGGGCCGAGGAGTTCTACTACCCGCCCTGGAAGCGGCTGCTCTTCCAGCTGCTTGTGAGC
CTCCCCCTGTGCCTGGCGTGCCTCGTCTGTGTCTTCTTGCTCATGCTTGGCTGCTTCCAG
CTGCAGGAGCTGGTGCTGAGCGTGAAGGGGTTGCCCCGTCTCGCCCGATTCCTGCCTAAG
GTCATGCTGGCCCTGCTTGTCAGTGTGAGTGCCGAGGGCTACAAGAAGCTAGCCATCTGG
CTCAATGACATGGAAAATTACCGGCTGGAGAGCGCCTATGAGAAGCACCTCATCATCAAA
GTTGTCCTGTTCCAGTTTGTCAACTCGTACCTGAGCCTCTTCTACATCGGTTTCTACCTC
AAGGACATGGAGCGCTTGAAAGAGATGCTGGCCACGCTGCTGATCACCCGCCAGTTCCTC
CAGAACGTGCGCGAGGTCCTGCAGCCGCACCTGTACCGGCGCCTGGGCCGCGGCGAGCTG
GGCCTGCGGGCCGTCTGGGAGCTGGCCCGAGCCCTGCTTGGCCTCCTGAGCCTCCGGCGC
CCTGCGCCCCGCCGCCTCGAACCCCAGGCGGATGAGGGCGGGGGCGGCGGCAGCGGGGGC
GGGGGCCGCAGGTGCCTCAGCGGGGGCTGCGGGGCGCCGGAGGAGGAGGAGGAGGCGGCG
CTGGTGGAGCGGCGGCGGGCGGGGGAAGGCGGGGAGGAGGGGGACGGGCCTCCAGGGGGC
AAGGAGGAGGACGAGGACGACGAGGAGGAGGAGGACGAGGAGGAAGAGGAGGACGAGGAG
GAGGGCGAGGAAGGGGGCCTCCTGGACTGCGGGCTCCGGCTGAAGAAGGTCAGCTTCGCT
GAGCGCGGCGCGGGGCGGCGTCGGCCCGGCCCAAGCCCGGAGGCCCTCCTGGAGGAAGGG
AGCCCCACTATGGTGGAGAAGGGGCTGGAGCCGGGAGTGTTCACCCTGGCCGAGGAGGAC
GACGAGGCGGAGGGGGCTCCCGGCAGCCCTGAACGGGAGCCCCCGGCCATCTTGTTCCGC
CGGGCCGGGGGCGAGGGCCGAGACCAGGGGCCCGACGGGGGCCCGGACCCGGAACCCGGC
TCCAACAGCGATTCGACCCGTAGGCAGAGACGGCAGAACCGGTCGTCTTGGATTGACCCG
CCGGAGGAGGAACACTCGCCCCAGCTCACCCAGGCAGAGCTGGAGAGCTGTATGAAGAAG
TACGAGGACACGTTCCAGGACTACCAGGAGATGTTCGTGCAGTTCGGCTACGTTGTGCTC
TTCTCGTCCGCCTTCCCCCTGGCGGCGCTGTGCGCCCTGGTCAACAACCTCATTGAGATC
CGCAGCGACGCCTTCAAGCTGTGCACCGGGCTGCAGCGGCCCTTCGGCCAGCGCGTGGAA
AGCATCGGCCAGTGGCAGAAGGTGATGGAGGCCATGGGTGTCCTAGCGATTGTGGTCAAC
TGCTACTTAATCGGCCAGTGCGGGCAGCTGCAGCGCCTCTTCCCCTGGCTGAGCCCGGAG
GCAGCCATCGTGTCGGTGGTAGTGCTCGAGCACTTCGCTCTGCTCCTCAAGTACCTCATC
CACGTGGCCATCCCCGATATCCCGGGCTGGGTGGCCGAGGAAATGGCCAAGCTGGAGTAC
CAGCGCCGCGAGGCCTTTAAGAGACACGAGCGCCAGGCCCAGCATCGCTACCAGCAGCAG
CAGCGCAGGCGGCGGGAGGAGGAGGAGCGACAGCGCCATGCAGAGCACCATGCCCGGCGG
GAGCATGATTCTGGTGGCCGAGAGGAGGCGAGGGCCGAGGGCTCTGGGCTGGACCCTGCC
ACCTCCTCCGAGAAGGCCTCTGCCAAGGCCAAGGGCAGCACTGCGGGTGGCCACGGGCCT
GAACGGCCCAAGCGCCCAGGGTCCCTGCTGGCACCCAACAACGTCATGAAGTTGAAGCAG
ATCATCCCACTGCAGGGCAAATTCCTCTCGTCAGGGGCCACATCCTCACTGGCTGCTGCA
GGGGCCGGAGCCACCACCCGGCCTCCCCCTGCCCAGTCACCCACAGGCAGCGACACCCGC
CTGCCTGCCTTCCTCAGCTTCAAGTTCCTCAAGTCACCCGAGACCCGGCGGGACTCTGAG
CGCAGCCACTCACCGCCCAAAGCCTTCCATGCTGGCAAGCTCTTCCCCTTTGGTGGCACC
CGGGCTGAGCCTGGGTCCAACGGGGCGGGCGGGCAGGCCCGGCCAGATGGGACCCCCAGC
AGTGGCAGCAGCCGGGTTCAGAGGAGTGGGCCGGTGGACGAGGCCCTGGCTGAGGAGCTG
GAAGCCCCCCGGCCCGAAGAGGAAGGCTCAGGGACAGCGCTGGCCCCCGTGGGCGCCCCT
GCCCTCCGCACCCGCCGCAGCCGGAGCCCCGCGCCGCCGCCGCCAATGCCGCTGCCCCGG
CCCCCGACACCGCCCGCAGGCTGCTGGCAGTGGGACGGGCCCTGGGGCTGCGGGGGCGAG
GGTGCCGCCCCCCGCCAGGCCCTGGCCGCTGCCGAGTGCCCACCCTGTGCCATGGCCGGG
CCCCCACCCGCCCCCCAGCCCCTGCCGGGAGACGCCAGCTTTTACAGCCTCCCGCCCCCA
CCGCTACCGCCCACCTCGGATCCCCTCGAGACCCCAGCGCCCTCCCCTAGCCCCAGCCCC
AGCCCCCAGGCCGTGTGCTGGCCCAGCGGCTGGCATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1232 |
| Molecular Weight
| 136033.0 |
| Theoretical pI
| 5.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["245-265", "282-302", "357-377", "401-421", "438-458", "751-771", "808-828", "842-862"]
|
| Protein Sequence
|
>Anoctamin-8
MAEAASGAGGTSLEGERGKRPPPEGEPAAPASGVLDKLFGKRLLQAGRYLVSHKAWMKTV
PTENCDVLMTFPDTTDDHTLLWLLNHIRVGIPELIVQVRHHRHTRAYAFFVTATYESLLR
GADELGLRKAVKAEFGGGTRGFSCEEDFIYENVESELRFFTSQERQSIIRFWLQNLRAKQ
GEALHNVRFLEDQPIIPELAARGIIQQVFPVHEQRILNRLMKSWVQAVCENQPLDDICDY
FGVKIAMYFAWLGFYTSAMVYPAVFGSVLYTFTEADQTSRDVSCVVFALFNVIWSTLFLE
EWKRRGAELAYKWGTLDSPGEAVEEPRPQFRGVRRISPITRAEEFYYPPWKRLLFQLLVS
LPLCLACLVCVFLLMLGCFQLQELVLSVKGLPRLARFLPKVMLALLVSVSAEGYKKLAIW
LNDMENYRLESAYEKHLIIKVVLFQFVNSYLSLFYIGFYLKDMERLKEMLATLLITRQFL
QNVREVLQPHLYRRLGRGELGLRAVWELARALLGLLSLRRPAPRRLEPQADEGGGGGSGG
GGRRCLSGGCGAPEEEEEAALVERRRAGEGGEEGDGPPGGKEEDEDDEEEEDEEEEEDEE
EGEEGGLLDCGLRLKKVSFAERGAGRRRPGPSPEALLEEGSPTMVEKGLEPGVFTLAEED
DEAEGAPGSPEREPPAILFRRAGGEGRDQGPDGGPDPEPGSNSDSTRRQRRQNRSSWIDP
PEEEHSPQLTQAELESCMKKYEDTFQDYQEMFVQFGYVVLFSSAFPLAALCALVNNLIEI
RSDAFKLCTGLQRPFGQRVESIGQWQKVMEAMGVLAIVVNCYLIGQCGQLQRLFPWLSPE
AAIVSVVVLEHFALLLKYLIHVAIPDIPGWVAEEMAKLEYQRREAFKRHERQAQHRYQQQ
QRRRREEEERQRHAEHHARREHDSGGREEARAEGSGLDPATSSEKASAKAKGSTAGGHGP
ERPKRPGSLLAPNNVMKLKQIIPLQGKFLSSGATSSLAAAGAGATTRPPPAQSPTGSDTR
LPAFLSFKFLKSPETRRDSERSHSPPKAFHAGKLFPFGGTRAEPGSNGAGGQARPDGTPS
SGSSRVQRSGPVDEALAEELEAPRPEEEGSGTALAPVGAPALRTRRSRSPAPPPPMPLPR
PPTPPAGCWQWDGPWGCGGEGAAPRQALAAAECPPCAMAGPPPAPQPLPGDASFYSLPPP
PLPPTSDPLETPAPSPSPSPSPQAVCWPSGWH
|
| External Links |
|---|
| GenBank ID Protein
| 55741655 |
| UniProtKB/Swiss-Prot ID
| Q9HCE9 |
| UniProtKB/Swiss-Prot Entry Name
| ANO8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_020959.2 |
| GeneCard ID
| ANO8 |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| Not Available |