| Identification |
|---|
| HMDB Protein ID
| CDBP02659 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anoctamin-6 |
| Description
| Not Available |
| Synonyms
|
- Transmembrane protein 16F
|
| Gene Name
| ANO6 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in chloride channel activity |
| Specific Function
| May act as a calcium-activated chloride channel |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12q12 |
| SNPs
| ANO6 |
| Gene Sequence
|
>2733 bp
ATGAAAAAGATGAGCAGGAATGTTTTGCTACAAATGGAGGAGGAGGAGGACGACGACGAT
GGGGATATCGTGTTGGAAAACCTTGGACAGACAATTGTCCCCGATTTGGGATCACTGGAA
AGTCAGCATGATTTTCGAACCCCGGAGTTTGAAGAATTTAATGGAAAACCTGACTCCCTC
TTTTTTAATGATGGCCAGCGAAGAATTGACTTTGTTCTAGTATATGAGGATGAAAGCAGA
AAAGAGACCAATAAAAAGGGTACAAATGAAAAACAAAGGAGGAAAAGACAAGCATACGAA
TCTAACCTTATCTGTCATGGCCTGCAGTTAGAAGCAACAAGATCAGTATTGGATGACAAG
CTTGTATTTGTAAAAGTACACGCACCATGGGAGGTGTTATGTACGTATGCTGAGATAATG
CACATCAAATTGCCTCTGAAACCCAATGATCTGAAAAACCGGTCCTCAGCCTTTGGTACA
CTCAACTGGTTTACCAAAGTCCTCAGTGTAGACGAAAGCATCATCAAGCCAGAGCAAGAG
TTTTTCACTGCCCCATTTGAGAAGAACCGGATGAATGATTTTTACATAGTTGATAGAGAT
GCTTTCTTCAATCCAGCCACCAGAAGCCGCATTGTTTACTTCATCCTCTCTCGGGTCAAG
TATCAAGTGATAAACAATGTTAGCAAGTTTGGGATCAACAGACTTGTAAACTCTGGGATC
TACAAGGCAGCTTTCCCACTCCATGATTGCAAATTCCGCCGTCAGTCAGAGGATCCCAGC
TGCCCTAATGAACGGTACCTTCTGTACAGAGAATGGGCTCATCCTCGAAGCATATACAAA
AAGCAGCCCTTGGATCTTATCAGGAAATACTATGGAGAGAAGATTGGAATCTACTTTGCT
TGGCTGGGCTATTACACTCAGATGCTTCTCCTGGCCGCAGTTGTAGGAGTGGCTTGCTTT
CTCTATGGATATCTTAATCAAGATAACTGTACATGGAGCAAAGAAGTTTGTCATCCTGAT
ATTGGTGGCAAGATCATAATGTGTCCTCAGTGTGATAGGCTTTGTCCATTCTGGAAACTC
AATATTACTTGCGAGTCCTCAAAGAAATTGTGCATCTTCGACAGTTTTGGAACCCTGGTC
TTTGCAGTATTTATGGGAGTATGGGTTACCTTGTTTTTGGAGTTTTGGAAGCGACGCCAG
GCAGAACTTGAGTATGAATGGGATACTGTTGAGTTACAGCAGGAAGAACAAGCCCGACCA
GAATACGAAGCACGATGTACTCACGTAGTGATAAATGAGATTACTCAGGAAGAAGAACGC
ATTCCCTTTACTGCCTGGGGAAAATGTATACGGATAACCCTCTGTGCCAGTGCTGTCTTT
TTCTGGATCCTATTGATCATCGCTTCAGTTATTGGGATCATTGTCTATAGGCTCTCGGTG
TTCATTGTATTTTCTGCAAAACTTCCCAAGAACATTAATGGAACAGACCCAATCCAGAAA
TACCTGACTCCACAGACAGCCACGTCCATCACGGCCTCCATCATCAGCTTTATAATTATC
ATGATTCTGAACACCATATATGAAAAAGTGGCAATTATGATTACTAACTTCGAACTCCCA
AGGACCCAGACTGATTATGAGAACAGCCTCACCATGAAGATGTTCTTATTCCAGTTTGTC
AACTACTACTCTTCATGCTTCTACATAGCATTCTTTAAGGGCAAATTTGTAGGCTATCCA
GGAGACCCAGTTTATTGGTTGGGAAAATACAGAAATGAAGAGTGTGACCCAGGTGGCTGT
CTTCTTGAACTGACAACTCAGCTGACAATAATCATGGGAGGAAAAGCAATCTGGAATAAC
ATACAAGAAGTATTATTGCCCTGGATCATGAATCTAATTGGGCGATTTCACAGAGTTTCT
GGATCAGAAAAGATAACCCCACGATGGGAACAGGACTACCATCTGCAGCCTATGGGCAAA
CTGGGATTATTTTATGAATATCTTGAAATGATTATTCAGTTTGGGTTCGTCACCTTATTT
GTGGCCTCTTTTCCACTGGCCCCTCTGTTGGCTCTCGTGAACAATATATTGGAAATAAGA
GTGGACGCATGGAAACTGACCACCCAGTTTAGACGCCTGGTACCAGAGAAAGCCCAAGAC
ATTGGAGCATGGCAGCCCATCATGCAAGGAATAGCAATTCTGGCTGTGGTGACCAATGCC
ATGATCATAGCTTTCACGTCGGACATGATCCCCCGCCTAGTGTACTACTGGTCCTTCTCC
GTCCCTCCCTACGGGGACCACACTTCCTACACCATGGAAGGGTACATCAACAACACTCTC
TCCATCTTCAAAGTCGCAGACTTCAAAAACAAAAGCAAGGGAAACCCGTACTCTGACCTG
GGTAACCATACCACATGCAGGTATCGTGATTTCCGATACCCACCTGGACACCCCCAGGAG
TATAAACACAACATCTACTATTGGCATGTGATTGCAGCCAAGCTGGCTTTTATCATTGTC
ATGGAGCACGTCATCTACTCTGTGAAATTTTTCATTTCATATGCAATTCCCGATGTATCA
AAACGCACAAAGAGCAAGATCCAGAGAGAAAAATACCTAACCCAAAAGCTTCTTCATGAG
AATCACCTCAAAGATATGACGAAAAATATGGGGGTGATAGCTGAGCGGATGATAGAAGCA
GTAGATAACAATTTACGGCCAAAATCAGAATAA
|
| Protein Properties |
|---|
| Number of Residues
| 910 |
| Molecular Weight
| 106164.1 |
| Theoretical pI
| 7.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["295-315", "376-396", "455-475", "514-534", "552-572", "670-690", "726-746", "825-845"]
|
| Protein Sequence
|
>Anoctamin-6
MKKMSRNVLLQMEEEEDDDDGDIVLENLGQTIVPDLGSLESQHDFRTPEFEEFNGKPDSL
FFNDGQRRIDFVLVYEDESRKETNKKGTNEKQRRKRQAYESNLICHGLQLEATRSVLDDK
LVFVKVHAPWEVLCTYAEIMHIKLPLKPNDLKNRSSAFGTLNWFTKVLSVDESIIKPEQE
FFTAPFEKNRMNDFYIVDRDAFFNPATRSRIVYFILSRVKYQVINNVSKFGINRLVNSGI
YKAAFPLHDCKFRRQSEDPSCPNERYLLYREWAHPRSIYKKQPLDLIRKYYGEKIGIYFA
WLGYYTQMLLLAAVVGVACFLYGYLNQDNCTWSKEVCHPDIGGKIIMCPQCDRLCPFWKL
NITCESSKKLCIFDSFGTLVFAVFMGVWVTLFLEFWKRRQAELEYEWDTVELQQEEQARP
EYEARCTHVVINEITQEEERIPFTAWGKCIRITLCASAVFFWILLIIASVIGIIVYRLSV
FIVFSAKLPKNINGTDPIQKYLTPQTATSITASIISFIIIMILNTIYEKVAIMITNFELP
RTQTDYENSLTMKMFLFQFVNYYSSCFYIAFFKGKFVGYPGDPVYWLGKYRNEECDPGGC
LLELTTQLTIIMGGKAIWNNIQEVLLPWIMNLIGRFHRVSGSEKITPRWEQDYHLQPMGK
LGLFYEYLEMIIQFGFVTLFVASFPLAPLLALVNNILEIRVDAWKLTTQFRRLVPEKAQD
IGAWQPIMQGIAILAVVTNAMIIAFTSDMIPRLVYYWSFSVPPYGDHTSYTMEGYINNTL
SIFKVADFKNKSKGNPYSDLGNHTTCRYRDFRYPPGHPQEYKHNIYYWHVIAAKLAFIIV
MEHVIYSVKFFISYAIPDVSKRTKSKIQREKYLTQKLLHENHLKDMTKNMGVIAERMIEA
VDNNLRPKSE
|
| External Links |
|---|
| GenBank ID Protein
| 218156299 |
| UniProtKB/Swiss-Prot ID
| Q4KMQ2 |
| UniProtKB/Swiss-Prot Entry Name
| ANO6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001025356.2 |
| GeneCard ID
| ANO6 |
| GenAtlas ID
| ANO6 |
| HGNC ID
| HGNC:25240 |
| References |
|---|
| General References
| Not Available |