| Identification |
|---|
| HMDB Protein ID
| CDBP02631 |
| Secondary Accession Numbers
| Not Available |
| Name
| Alkaline ceramidase 3 |
| Description
| Not Available |
| Synonyms
|
- AlkCDase 3
- Alkaline CDase 3
- Alkaline dihydroceramidase SB89
- Alkaline phytoceramidase
- aPHC
|
| Gene Name
| ACER3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Specific Function
| Hydrolyzes only phytoceramide into phytosphingosine and free fatty acid. Does not have reverse activity.
|
| GO Classification
|
| Biological Process |
| sphingosine biosynthetic process |
| ceramide metabolic process |
| positive regulation of cell proliferation |
| phytosphingosine biosynthetic process |
| phospholipid metabolic process |
| Cellular Component |
| integral to endoplasmic reticulum membrane |
| integral to Golgi membrane |
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides |
| Molecular Function |
| phytoceramidase activity |
| Process |
| metabolic process |
| ceramide metabolic process |
| sphingolipid metabolic process |
| membrane lipid metabolic process |
| primary metabolic process |
| lipid metabolic process |
| cellular lipid metabolic process |
| sphingoid metabolic process |
|
| Cellular Location
|
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Sphingolipid Metabolism |    |  | | Gaucher Disease |    | Not Available | | Globoid Cell Leukodystrophy |    | Not Available | | Metachromatic Leukodystrophy (MLD) |    | Not Available | | Fabry disease |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| ACER3 |
| Gene Sequence
|
>804 bp
ATGGCTCCGGCCGCGGACCGAGAGGGCTACTGGGGCCCCACGACCTCCACGCTGGACTGG
TGCGAGGAGAACTACTCCGTGACCTGGTACATCGCCGAGTTCTGGAATACAGTGAGTAAC
CTGATCATGATTATACCTCCAATGTTCGGTGCAATTCAGAGTGTTAGAGACGGTCTGGAA
AAACGGTACATTGCTTCTTATTTAGCACTCACAGTGGTAGGAATGGGATCCTGGTGCTTC
CACATGACTCTGAAATATGAAATGCAGCTATTGGATGAACTCCCAATGATATACAGCTGT
TGCATATTTGTGTACTGCATGTTTGAATGTTTCAAGATCAAGAACTCAGTAAACTACCAT
CTGCTTTTTACCTTAGTTCTATTCAGTTTAATAGTAACCACAGTTTACCTTAAGGTAAAA
GAGCCAATATTCCATCAGGTCATGTATGGAATGTTGGTCTTTACATTAGTACTTCGATCT
ATTTATATTGTTACATGGGTTTATCCATGGCTTAGAGGACTGGGTTATACATCATTGGGT
ATATTTTTATTGGGATTTTTATTTTGGAATATAGATAACATATTTTGTGAGTCACTGAGG
AACTTTCGAAAGAAGGTACCACCTATCATAGGTATTACCACACAATTTCATGCATGGTGG
CATATTTTAACTGGCCTTGGTTCCTATCTTCACATCCTTTTCAGTTTGTATACAAGAACA
CTTTACCTGAGATATAGGCCAAAAGTGAAGTTTCTCTTTGGAATCTGGCCAGTGATCCTG
TTTGAGCCTCTCAGGAAGCATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 267 |
| Molecular Weight
| Not Available |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Alkaline ceramidase 3
MAPAADREGYWGPTTSTLDWCEENYSVTWYIAEFWNTVSNLIMIIPPMFGAVQSVRDGLE
KRYIASYLALTVVGMGSWCFHMTLKYEMQLLDELPMIYSCCIFVYCMFECFKIKNSVNYH
LLFTLVLFSLIVTTVYLKVKEPIFHQVMYGMLVFTLVLRSIYIVTWVYPWLRGLGYTSLG
IFLLGFLFWNIDNIFCESLRNFRKKVPPIIGITTQFHAWWHILTGLGSYLHILFSLYTRT
LYLRYRPKVKFLFGIWPVILFEPLRKH
|
| External Links |
|---|
| GenBank ID Protein
| 14669436 |
| UniProtKB/Swiss-Prot ID
| Q9NUN7 |
| UniProtKB/Swiss-Prot Entry Name
| ACER3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF214454 |
| GeneCard ID
| ACER3 |
| GenAtlas ID
| ACER3 |
| HGNC ID
| HGNC:16066 |
| References |
|---|
| General References
| Not Available |