| Identification |
|---|
| HMDB Protein ID
| CDBP02630 |
| Secondary Accession Numbers
| Not Available |
| Name
| FAD synthase |
| Description
| Not Available |
| Synonyms
|
- FAD pyrophosphorylase
- FAD synthase region
- FMN adenylyltransferase
- Flavin adenine dinucleotide synthase
- Molybdenum cofactor biosynthesis protein-like region
|
| Gene Name
| FLAD1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in FMN adenylyltransferase activity |
| Specific Function
| Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.
|
| GO Classification
|
| Biological Process |
| riboflavin metabolic process |
| FAD biosynthetic process |
| Mo-molybdopterin cofactor biosynthetic process |
| Cellular Component |
| cytosol |
| Function |
| fmn adenylyltransferase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring phosphorus-containing groups |
| nucleotidyltransferase activity |
| adenylyltransferase activity |
| Molecular Function |
| ATP binding |
| FMN adenylyltransferase activity |
| Process |
| fadh2 metabolic process |
| fad biosynthetic process |
| metabolic process |
| coenzyme biosynthetic process |
| cellular metabolic process |
| oxidoreduction coenzyme metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| mo-molybdopterin cofactor biosynthetic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Riboflavin Metabolism |    |  | | FAD biosynthesis | Not Available | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q21.3 |
| SNPs
| FLAD1 |
| Gene Sequence
|
>1764 bp
ATGGGTTGGGATTTGGGAACACGTTTATTCCAGAGGCAGGAACAAAGGAGTCGCTTGTCA
AGGATCTGGTTAGAGAAGACTAGGGTCTTCCTCGAAGGAAGCACGCGCACGCCTGCTCTC
CCCCATTGTCTTTTCTGGCTTCTCCAGGTTCCCTCGACCCAGGACCCCCTGTTCCCAGGC
TATGGCCCCCAGTGCCCTGTAGACCTGGCAGGCCCCCCGTGCTTGCGACCCCTATTTGGG
GGTCTGGGTGGCTACTGGAGGGCCTTGCAGAGGGGCAGAGAAGGCAGGACCATGACATCT
AGGGCCTCTGAACTTTCTCCGGGGCGCAGCGTGACGGCTGGCATCATCATTGTTGGAGAT
GAGATCCTTAAGGGACACACTCAGGACACCAACACCTTCTTTCTGTGCCGGACACTGCGC
TCCCTAGGGGTCCAGGTTTGCCGAGTCTCAGTTGTACCTGATGAGGTAGCCACCATTGCA
GCTGAGGTCACTTCTTTCTCCAACCGCTTCACCCATGTCCTCACAGCAGGGGGCATCGGC
CCCACTCATGATGATGTGACCTTTGAGGCAGTGGCACAGGCCTTTGGAGATGAGCTGAAG
CCACACCCCAAGTTGGAAGCAGCCACCAAAGCCCTAGGAGGGGAAGGCTGGGAGAAGCTA
TCATTGGTGCCCTCCTCTGCCCGCCTGCATTATGGCACAGATCCTTGCACTGGTCAACCT
TTCAGATTCCCTCTGGTCTCCGTCCGAAACGTCTACCTCTTCCCAGGCATTCCAGAGCTG
CTGCGGCGGGTGCTGGAGGGGATGAAGGGACTATTCCAAAACCCAGCTGTTCAGTTCCAC
TCAAAGGAGCTATATGTGGCTGCTGATGAAGCCTCCATCGCCCCCATTCTGGCTGAGGCC
CAGGCCCACTTTGGACGTAGGCTTGGCCTGGGTTCCTACCCTGACTGGGGCAGCAACTAC
TATCAGGTGAAGCTGACTCTAGACTCAGAGGAAGAAGGACCCCTGGAGGAATGCTTGGCC
TACCTGACTGCCCGTTTGCCCCAGGGATCGCTGGTCCCCTACATGCCCAACGCTGTGGAG
CAGGCCAGTGAGGCTGTATACAAACTCGCTGAATCAGGGTCTTCTTTGGGGAAAAAGGTG
GCAGGTGCCCTACAGACCATTGAGACCTCCCTGGCTCAGTACAGCCTCACCCAGCTCTGT
GTGGGCTTCAACGGGGGCAAAGACTGCACTGCCCTCCTGCACCTCTTCCATGCAGCTGTG
CAGAGGAAATTACCTGATGTTCCAAACCCCCTCCAGATCCTGTATATCCGCAGCATCTCC
CCTTTCCCTGAGCTGGAACAGTTTCTACAGGACACTATCAAGAGGTATAATCTGCAGATG
TTGGAAGCTGAGGGCAGCATGAAGCAGGCCCTGGGTGAACTGCAGGCACGGCACCCCCAG
CTGGAGGCTGTCCTTATGGGCACCCGCCGGACTGACCCCTACTCCTGTAGCCTCTGCCCT
TTCAGCCCCACTGACCCAGGCTGGCCCGCATTCATGCGCATCAACCCACTGCTGGACTGG
ACCTACAGAGACATCTGGGATTTTCTGCGTCAGCTGTTTGTCCCATACTGTATCCTGTAT
GACCGAGGATACACATCACTGGGGAGTCGGGAGAATACCGTGCGGAACCCGGCCCTGAAG
TGCCTGAGCCCAGGAGGACACCCCACATACCGTCCAGCCTATCTACTGGAGAACGAAGAA
GAGGAGCGGAACTCCCGCACATGA
|
| Protein Properties |
|---|
| Number of Residues
| 587 |
| Molecular Weight
| 49197.795 |
| Theoretical pI
| 5.962 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>FAD synthase
MGWDLGTRLFQRQEQRSRLSRIWLEKTRVFLEGSTRTPALPHCLFWLLQVPSTQDPLFPG
YGPQCPVDLAGPPCLRPLFGGLGGYWRALQRGREGRTMTSRASELSPGRSVTAGIIIVGD
EILKGHTQDTNTFFLCRTLRSLGVQVCRVSVVPDEVATIAAEVTSFSNRFTHVLTAGGIG
PTHDDVTFEAVAQAFGDELKPHPKLEAATKALGGEGWEKLSLVPSSARLHYGTDPCTGQP
FRFPLVSVRNVYLFPGIPELLRRVLEGMKGLFQNPAVQFHSKELYVAADEASIAPILAEA
QAHFGRRLGLGSYPDWGSNYYQVKLTLDSEEEGPLEECLAYLTARLPQGSLVPYMPNAVE
QASEAVYKLAESGSSLGKKVAGALQTIETSLAQYSLTQLCVGFNGGKDCTALLHLFHAAV
QRKLPDVPNPLQILYIRSISPFPELEQFLQDTIKRYNLQMLEAEGSMKQALGELQARHPQ
LEAVLMGTRRTDPYSCSLCPFSPTDPGWPAFMRINPLLDWTYRDIWDFLRQLFVPYCILY
DRGYTSLGSRENTVRNPALKCLSPGGHPTYRPAYLLENEEEERNSRT
|
| External Links |
|---|
| GenBank ID Protein
| 41872389 |
| UniProtKB/Swiss-Prot ID
| Q8NFF5 |
| UniProtKB/Swiss-Prot Entry Name
| FAD1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_025207.4 |
| GeneCard ID
| FLAD1 |
| GenAtlas ID
| FLAD1 |
| HGNC ID
| HGNC:24671 |
| References |
|---|
| General References
| Not Available |