| Identification |
|---|
| HMDB Protein ID
| CDBP02616 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kynurenine formamidase |
| Description
| Not Available |
| Synonyms
|
- KF
- Kynurenine formamidase
- KFA
- KFase
- Arylformamidase
- N-formylkynurenine formamidase
- FKF
|
| Gene Name
| AFMID |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity).
|
| GO Classification
|
| Biological Process |
| tryptophan catabolic process |
| tryptophan catabolic process to kynurenine |
| Cellular Component |
| cytosol |
| nucleus |
| Function |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| arylformamidase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- cytosol
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | L-tryptophan degradation via kynurenine pathway | Not Available | Not Available | | Glyoxylate and dicarboxylate metabolism | Not Available |  | | Tryptophan Metabolism |    |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 17 |
| Locus
| 17q25.3 |
| SNPs
| AFMID |
| Gene Sequence
|
>912 bp
ATGATGGATGTGTCTGGTGTGGGTTTCCCAAGCAAGGTTCCTTGGAAGAAGATGTCTGCA
GAGGAGCTGGAGAATCAGTACTGTCCCAGCCGATGGGTTGTCCGACTGGGAGCAGAGGAA
GCCTTGAGGACCTACTCACAGATAGGAATTGAAGCCACCACAAGGGCCCGGGCCACCAGG
AAGAGCCTGCTGCATGTCCCCTATGGAGACGGCGAAGGGGAGAAAGTGGACATTTACTTC
CCCGACGAGTCGTCTGAAGCCTTGCCTTTCTTCCTGTTCTTTCACGGAGGATACTGGCAG
AGCGGAAGTAAGGATGAGTCTGCCTTCATGGTCCACCCGCTGACGGCACAGGGAGTGGCC
GTGGTAATAGTGGCTTACGGCATCGCCCCCAAAGGCACCCTGGACCACATGGTAGACCAG
GTGACCCGCAGCGTTGCGTTTGTCCAGAAGCGGTATCCAAGCAACAAGGGAATTTACCTG
TGTGGACACTCAGCCGGGGCCCACCTGGCTGCCATGATGCTCCTGGCCGACTGGACCAAG
CATGGGGTCACGCCCAACCTCAGAGGCTTTTTCCTGGTGAGTGGGGTCTTTGACCTGGAG
CCCATCGTGTATACTTCACAGAACGTTGCTCTCCAGCTGACCCTGGAGGACGCTCAGAGG
AATAGCCCCCAGCTGAAGGTGGCCCAGGCACAGCCGGTGGACCCCACCTGCCGTGTGCTG
GTGGTCGTGGGCCAGTTCGACTCCCCCGAATTCCACCGACAGTCCTGGGAGTTTTACCAG
ACCCTGTGTCAAGGAGAGTGGAAAGCCTCATTTGAAGAGCTCCACGATGTGGACCACTTT
GAAATTGTTGAGAATCTGACCCAGAAGGACAACGTGCTCACCCAGATTATCTTGAAAACA
ATCTTCCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 303 |
| Molecular Weight
| 33991.5 |
| Theoretical pI
| 5.908 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Probable arylformamidase
MMDVSGVGFPSKVPWKKMSAEELENQYCPSRWVVRLGAEEALRTYSQIGIEATTRARATR
KSLLHVPYGDGEGEKVDIYFPDESSEALPFFLFFHGGYWQSGSKDESAFMVHPLTAQGVA
VVIVAYGIAPKGTLDHMVDQVTRSVAFVQKRYPSNKGIYLCGHSAGAHLAAMMLLADWTK
HGVTPNLRGFFLVSGVFDLEPIVYTSQNVALQLTLEDAQRNSPQLKVAQAQPVDPTCRVL
VVVGQFDSPEFHRQSWEFYQTLCQGEWKASFEELHDVDHFEIVENLTQKDNVLTQIILKT
IFQ
|
| External Links |
|---|
| GenBank ID Protein
| 124375910 |
| UniProtKB/Swiss-Prot ID
| Q63HM1 |
| UniProtKB/Swiss-Prot Entry Name
| AFMID_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC132824 |
| GeneCard ID
| AFMID |
| GenAtlas ID
| AFMID |
| HGNC ID
| HGNC:20910 |
| References |
|---|
| General References
| Not Available |