| Identification |
|---|
| HMDB Protein ID
| CDBP02602 |
| Secondary Accession Numbers
| Not Available |
| Name
| Fumarate hydratase |
| Description
| Not Available |
| Synonyms
|
- SubName: Fumarate hydratase, isoform CRA_c
- SubName: cDNA, FLJ92753, Homo sapiens fumarate hydratase (FH), nuclear gene encodingmitochondrial protein, mRNA
|
| Gene Name
| FH |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in fumarate hydratase activity |
| Specific Function
| Not Available |
| GO Classification
|
| Component |
| tricarboxylic acid cycle enzyme complex |
| macromolecular complex |
| protein complex |
| Function |
| fumarate hydratase activity |
| catalytic activity |
| lyase activity |
| carbon-oxygen lyase activity |
| hydro-lyase activity |
| Process |
| oxoacid metabolic process |
| carboxylic acid metabolic process |
| cofactor metabolic process |
| coenzyme metabolic process |
| acetyl-coa metabolic process |
| acetyl-coa catabolic process |
| tricarboxylic acid cycle |
| dicarboxylic acid metabolic process |
| fumarate metabolic process |
| metabolic process |
| cellular metabolic process |
| organic acid metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q42.1 |
| SNPs
| FH |
| Gene Sequence
|
>1533 bp
ATGTACCGAGCACTTCGGCTCCTCGCGCGCTCGCGTCCCCTCGTGCGGGCTCCAGCCGCA
GCCTTAGCTTCGGCTCCCGGCTTGGGTGGCGCGGCCGTGCCCTCGTTTTGGCCTCCGAAC
GCGGCTCGAATGGCAAGCCAAAATTCCTTCCGGATAGAATATGATACCTTTGGTGAACTA
AAGGTGCCAAATGATAAGTATTATGGCGCCCAGACCGTGAGATCTACGATGAACTTTAAG
ATTGGAGGTGTGACAGAACGCATGCCAACCCCAGTTATTAAAGCTTTTGGCATCTTGAAG
CGAGCGGCCGCTGAAGTAAACCAGGATTATGGTCTTGATCCAAAGATTGCTAATGCAATA
ATGAAGGCAGCAGATGAGGTAGCTGAAGGTAAATTAAATGATCATTTTCCTCTCGTGGTA
TGGCAGACTGGATCAGGAACTCAGACAAATATGAATGTAAATGAAGTCATTAGCAATAGA
GCAATTGAAATGTTAGGAGGTGAACTTGGCAGCAAGATACCTGTGCATCCCAACGATCAT
GTTAATAAAAGCCAGAGCTCAAATGATACTTTTCCCACAGCAATGCACATTGCTGCTGCA
ATAGAAGTTCATGAAGTACTGTTACCAGGACTACAGAAGTTACATGATGCTCTTGATGCA
AAATCCAAAGAGTTTGCACAGATCATCAAGATTGGACGTACTCATACTCAGGATGCTGTT
CCACTTACTCTTGGGCAGGAATTTAGTGGTTATGTTCAACAAGTAAAATATGCAATGACA
AGAATAAAAGCTGCCATGCCAAGAATCTATGAGCTCGCAGCTGGAGGCACTGCTGTTGGT
ACAGGTTTAAATACTAGAATTGGCTTTGCAGAAAAGGTTGCTGCAAAAGTGGCTGCACTT
ACAGGCTTGCCTTTTGTCACTGCTCCGAATAAATTTGAAGCTCTGGCTGCTCATGACGCT
CTGGTTGAGCTCAGTGGAGCCATGAACACTACTGCCTGCAGTCTGATGAAGATAGCAAAT
GATATTCGATTTTTGGGTTCTGGTCCTCGGTCAGGTCTGGGAGAATTGATCTTGCCTGAA
AATGAACCAGGAAGCAGTATCATGCCAGGCAAGGTGAACCCTACTCAGTGTGAAGCAATG
ACCATGGTTGCAGCCCAAGTCATGGGGAACCATGTTGCTGTCACTGTCGGAGGCAGCAAT
GGACATTTTGAGTTGAATGTTTTCAAGCCAATGATGATTAAAAATGTGTTACACTCAGCC
AGGCTGCTGGGGGATGCTTCAGTTTCCTTTACAGAAAACTGCGTGGTGGGAATCCAGGCC
AATACAGAAAGGATCAACAAGCTGATGAATGAGTCTCTAATGTTGGTGACAGCTCTCAAT
CCTCATATAGGGTATGACAAGGCAGCAAAGATTGCTAAGACAGCACACAAAAATGGATCA
ACCTTAAAGGAAACTGCTATCGAACTTGGCTATCTCACAGCAGAGCAGTTTGACGAATGG
GTAAAACCTAAGGACATGCTGGGTCCAAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 510 |
| Molecular Weight
| 54636.6 |
| Theoretical pI
| 9.17 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Fumarate hydratase
MYRALRLLARSRPLVRAPAAALASAPGLGGAAVPSFWPPNAARMASQNSFRIEYDTFGEL
KVPNDKYYGAQTVRSTMNFKIGGVTERMPTPVIKAFGILKRAAAEVNQDYGLDPKIANAI
MKAADEVAEGKLNDHFPLVVWQTGSGTQTNMNVNEVISNRAIEMLGGELGSKIPVHPNDH
VNKSQSSNDTFPTAMHIAAAIEVHEVLLPGLQKLHDALDAKSKEFAQIIKIGRTHTQDAV
PLTLGQEFSGYVQQVKYAMTRIKAAMPRIYELAAGGTAVGTGLNTRIGFAEKVAAKVAAL
TGLPFVTAPNKFEALAAHDALVELSGAMNTTACSLMKIANDIRFLGSGPRSGLGELILPE
NEPGSSIMPGKVNPTQCEAMTMVAAQVMGNHVAVTVGGSNGHFELNVFKPMMIKNVLHSA
RLLGDASVSFTENCVVGIQANTERINKLMNESLMLVTALNPHIGYDKAAKIAKTAHKNGS
TLKETAIELGYLTAEQFDEWVKPKDMLGPK
|
| External Links |
|---|
| GenBank ID Protein
| 189065486 |
| UniProtKB/Swiss-Prot ID
| B1ANK7 |
| UniProtKB/Swiss-Prot Entry Name
| B1ANK7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK312415 |
| GeneCard ID
| FH |
| GenAtlas ID
| FH |
| HGNC ID
| HGNC:3700 |
| References |
|---|
| General References
| Not Available |