| Identification |
|---|
| HMDB Protein ID
| CDBP02583 |
| Secondary Accession Numbers
| Not Available |
| Name
| Transmembrane protein 55A |
| Description
| Not Available |
| Synonyms
|
- PtdIns-4,5-P2 4-Ptase II
- Type II phosphatidylinositol 4,5-bisphosphate 4-phosphatase
|
| Gene Name
| TMEM55A |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 4,5-bisphosphate. Does not hydrolyze phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate, inositol 3,5-bisphosphate, inositol 3,4-bisphosphate, phosphatidylinositol 5-monophosphate, phosphatidylinositol 4-monophosphate and phosphatidylinositol 3-monophosphate.
|
| GO Classification
|
| Cellular Component |
| late endosome membrane |
| lysosomal membrane |
| integral to membrane |
| Molecular Function |
| hydrolase activity |
|
| Cellular Location
|
- Late endosome membrane
- Lysosome membrane
- Multi-pass membrane protein
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8q21.3 |
| SNPs
| TMEM55A |
| Gene Sequence
|
>774 bp
ATGGCTGCTGATGGGGTGGACGAACGCTCGCCTCTGCTGTCAGCATCCCACTCCGGAAAT
GTCACTCCCACCGCCCCACCGTACTTGCAAGAAAGCAGCCCCAGAGCGGAGCTCCCACCT
CCATATACAGCCATTGCCAGTCCAGACGCCAGTGGTATTCCAGTAATAAACTGCCGTGTG
TGCCAATCACTAATCAATTTGGATGGCAAGCTTCACCAGCATGTGGTTAAGTGCACAGTT
TGCAATGAAGCTACGCCAATCAAAAACCCCCCAACAGGCAAGAAATATGTTAGATGCCCT
TGTAATTGTCTTCTCATTTGTAAGGACACATCTCGGCGAATAGGATGCCCAAGACCCAAC
TGTAGACGGATAATTAACCTTGGCCCAGTAATGCTTATTTCTGAAGAACAACCAGCTCAG
CCTGCATTGCCAATCCAACCAGAAGGTACAAGGGTCGTGTGTGGGCACTGTGGAAACACA
TTCCTGTGGATGGAACTGAGGTTCAACACTCTGGCAAAATGCCCACACTGCAAAAAAATC
TCCTCAGTGGGTAGTGCACTTCCACGAAGACGCTGCTGTGCATATATTACCATTGGAATG
ATATGTATTTTCATTGGAGTTGGGTTAACTGTTGGCACCCCAGATTTTGCAAGGCGATTT
CGAGCAACCTATGTTTCTTGGGCAATTGCTTATCTCCTAGGATTGATCTGCCTTATCCGA
GCTTGTTATTGGGGAGCCATAAGAGTCAGTTATCCAGAACACAGTTTTGCATAA
|
| Protein Properties |
|---|
| Number of Residues
| 257 |
| Molecular Weight
| 28080.62 |
| Theoretical pI
| 8.679 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Transmembrane protein 55A
MAADGVDERSPLLSASHSGNVTPTAPPYLQESSPRAELPPPYTAIASPDASGIPVINCRV
CQSLINLDGKLHQHVVKCTVCNEATPIKNPPTGKKYVRCPCNCLLICKDTSRRIGCPRPN
CRRIINLGPVMLISEEQPAQPALPIQPEGTRVVCGHCGNTFLWMELRFNTLAKCPHCKKI
SSVGSALPRRRCCAYITIGMICIFIGVGLTVGTPDFARRFRATYVSWAIAYLLGLICLIR
ACYWGAIRVSYPEHSFA
|
| External Links |
|---|
| GenBank ID Protein
| 189054014 |
| UniProtKB/Swiss-Prot ID
| Q8N4L2 |
| UniProtKB/Swiss-Prot Entry Name
| TM55A_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK313783 |
| GeneCard ID
| TMEM55A |
| GenAtlas ID
| TMEM55A |
| HGNC ID
| HGNC:25452 |
| References |
|---|
| General References
| Not Available |