| Identification |
|---|
| HMDB Protein ID
| CDBP02563 |
| Secondary Accession Numbers
| Not Available |
| Name
| Phosphatidate phosphatase PPAPDC1B |
| Description
| Not Available |
| Synonyms
|
- Phosphatidic acid phosphatase type 2 domain-containing protein 1B
|
| Gene Name
| PPAPDC1B |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Displays magnesium-independent phosphatidate phosphatase activity in vitro. Catalyzes the conversion of phosphatidic acid to diacylglycerol. May be a metastatic suppressor for hepatocellular carcinoma.
|
| GO Classification
|
| Biological Process |
| phospholipid dephosphorylation |
| Cellular Component |
| cytoplasm |
| plasma membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| phosphatidate phosphatase activity |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| 8 |
| Locus
| 8p11.23 |
| SNPs
| PPAPDC1B |
| Gene Sequence
|
>672 bp
ATGTGGCTCTACCGGAACCCCTACGTGGAGGCGGAGTATTTCCCCACCAAGCCGATGTTT
GTTATTGCATTTCTCTCTCCACTGTCTCTGATCTTCCTGGCCAAATTTCTCAAGAAGGCA
GACACAAGAGACAGCAGACAAGCCTGCCTGGCTGCCAGCCTTGCCCTGGCTCTGAATGGC
GTCTTTACCAACACAATAAAACTGATCGTAGGGAGGCCACGCCCAGATTTCTTCTACCGC
TGCTTCCCTGATGGGCTAGCCCATTCTGACTTGATGTGTACAGGGGATAAGGACGTGGTG
AATGAGGGCCGAAAGAGCTTCCCCAGTGGACATTCTTCCTTTGCATTTGCTGGTCTGGCC
TTTGCGTCCTTCTACCTGGCAGGGAAGTTACACTGCTTCACACCACAAGGCCGTGGGAAA
TCTTGGAGGTTCTGTGCCTTTCTGTCACCTCTACTTTTTGCAGCTGTGATTGCACTGTCC
CGCACATGTGACTACAAGCATCACTGGCAAGATGTACTAGTTGGATCCATGATTGGAATG
ACATTTGCCTATGTCTGCTATCGGCAGTATTATCCTCCTCTGACTGATGCAGAATGCCAT
AAACCATTTCAAGACAAACTTGTACTTTCCACTGCACAGAAGCCTGGGGATTCTTATTGT
TTTGATATTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 223 |
| Molecular Weight
| 29484.025 |
| Theoretical pI
| 8.504 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Phosphatidate phosphatase PPAPDC1B
MWLYRNPYVEAEYFPTKPMFVIAFLSPLSLIFLAKFLKKADTRDSRQACLAASLALALNG
VFTNTIKLIVGRPRPDFFYRCFPDGLAHSDLMCTGDKDVVNEGRKSFPSGHSSFAFAGLA
FASFYLAGKLHCFTPQGRGKSWRFCAFLSPLLFAAVIALSRTCDYKHHWQDVLVGSMIGM
TFAYVCYRQYYPPLTDAECHKPFQDKLVLSTAQKPGDSYCFDI
|
| External Links |
|---|
| GenBank ID Protein
| 21542541 |
| UniProtKB/Swiss-Prot ID
| Q8NEB5 |
| UniProtKB/Swiss-Prot Entry Name
| PPC1B_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC033025 |
| GeneCard ID
| PPAPDC1B |
| GenAtlas ID
| PPAPDC1B |
| HGNC ID
| HGNC:25026 |
| References |
|---|
| General References
| Not Available |