| Identification |
|---|
| HMDB Protein ID
| CDBP02560 |
| Secondary Accession Numbers
| Not Available |
| Name
| Presqualene diphosphate phosphatase |
| Description
| Not Available |
| Synonyms
|
- PPAP2 domain-containing protein 2
- Phosphatidic acid phosphatase type 2 domain-containing protein 2
|
| Gene Name
| PPAPDC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| Phosphatase that dephosphorylates presqualene diphosphate (PSDP) into presqualene monophosphate (PSMP), suggesting that it may be indirectly involved in innate immunity. PSDP is a bioactive lipid that rapidly remodels to presqualene monophosphate PSMP upon cell activation. Displays diphosphate phosphatase activity with a substrate preference for PSDP > FDP > phosphatidic acid |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p24.1 |
| SNPs
| PPAPDC2 |
| Gene Sequence
|
>888 bp
ATGCCAAGTCCCCGGAGGAGCATGGAGGGACGGCCGCTGGGCGTCTCCGCTTCGAGCAGC
AGCAGCAGCCCCGGCAGCCCAGCCCATGGCGGCGGTGGCGGCGGCAGCAGGTTTGAGTTC
CAGTCCCTGCTCAGCAGCCGCGCCACGGCCGTGGACCCCACCTGCGCCCGGCTCCGTGCA
TCGGAGAGCCCAGTTCACCGCCGCGGCTCCTTCCCCCTGGCCGCGGCGGGCCCCTCGCAG
TCGCCCGCGCCTCCGCTGCCCGAGGAGGACCGCATGGACTTGAACCCGTCCTTCCTGGGC
ATCGCCCTGCGCTCCCTGCTGGCCATCGACCTGTGGCTGTCCAAGAAGCTGGGGGTGTGC
GCGGGAGAGAGCTCGTCGTGGGGCAGCGTGCGACCCCTTATGAAGCTGCTGGAGATCTCG
GGACACGGCATCCCCTGGCTGCTGGGCACCCTCTACTGCCTGTGCAGGAGCGACAGCTGG
GCCGGGCGCGAGGTGCTGATGAACCTGCTCTTCGCCCTGCTGTTGGACCTGCTGCTGGTG
GCCTTGATCAAAGGGCTGGTCCGCAGGCGCCGCCCGGCCCACAACCAGATGGACATGTTT
GTCACTCTCTCGGTGGACAAGTACTCCTTCCCCTCGGGCCATGCCACAAGGGCCGCCCTG
ATGTCGAGGTTCATCCTGAACCACCTGGTGCTGGCCATTCCACTGAGGGTGCTGGTGGTT
CTGTGGGCCTTCGTCTTGGGCCTATCCAGGGTCATGCTGGGGCGGCACAATGTCACCGAC
GTAGCTTTTGGCTTTTTTCTGGGCTACATGCAGTACAGCATCGTGGACTATTGCTGGCTC
TCACCCCATAATGCTCCGGTCCTCTTTTTACTGTGGAGTCAACGATGA
|
| Protein Properties |
|---|
| Number of Residues
| 295 |
| Molecular Weight
| 32193.2 |
| Theoretical pI
| 10.42 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["133-153", "165-185", "229-249", "261-281"]
|
| Protein Sequence
|
>Presqualene diphosphate phosphatase
MPSPRRSMEGRPLGVSASSSSSSPGSPAHGGGGGGSRFEFQSLLSSRATAVDPTCARLRA
SESPVHRRGSFPLAAAGPSQSPAPPLPEEDRMDLNPSFLGIALRSLLAIDLWLSKKLGVC
AGESSSWGSVRPLMKLLEISGHGIPWLLGTLYCLCRSDSWAGREVLMNLLFALLLDLLLV
ALIKGLVRRRRPAHNQMDMFVTLSVDKYSFPSGHATRAALMSRFILNHLVLAIPLRVLVV
LWAFVLGLSRVMLGRHNVTDVAFGFFLGYMQYSIVDYCWLSPHNAPVLFLLWSQR
|
| External Links |
|---|
| GenBank ID Protein
| 66773040 |
| UniProtKB/Swiss-Prot ID
| Q8IY26 |
| UniProtKB/Swiss-Prot Entry Name
| PPAC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_203453.2 |
| GeneCard ID
| PPAPDC2 |
| GenAtlas ID
| PPAPDC2 |
| HGNC ID
| HGNC:23682 |
| References |
|---|
| General References
| Not Available |