| Identification |
|---|
| HMDB Protein ID
| CDBP02542 |
| Secondary Accession Numbers
| Not Available |
| Name
| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
| Description
| Not Available |
| Synonyms
|
- N-acyl phosphatidylethanolamine phospholipase D
- NAPE-PLD
- NAPE-hydrolyzing phospholipase D
|
| Gene Name
| NAPEPLD |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metal ion binding |
| Specific Function
| Hydrolyzes N-acyl-phosphatidylethanolamines (NAPEs) to produce N-acylethanolamines (NAEs) and phosphatidic acid. Responsible for the generation of anandamide (N-arachidonoylethanolamine), the ligand of cannabinoid and vanilloid receptors (By similarity).
|
| GO Classification
|
| Biological Process |
| phospholipid catabolic process |
| Cellular Component |
| membrane |
| Molecular Function |
| metal ion binding |
| NAPE-specific phospholipase D activity |
| zinc ion binding |
|
| Cellular Location
|
- Membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Retrograde endocannabinoid signaling | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q22.1 |
| SNPs
| NAPEPLD |
| Gene Sequence
|
>1182 bp
ATGGATGAAAATGAAAGCAACCAGTCTCTGATGACAAGCAGCCAATATCCTAAAGAAGCA
GTAAGAAAACGTCAAAATTCAGCACGGAATTCCGGAGCAAGTGATTCTTCTAGGTTTTCT
AGGAAAAGCTTCAAACTGGATTATAGACTAGAAGAAGATGTAACTAAATCCAAGAAAGGA
AAAGATGGGAGATTTGTGAATCCGTGGCCAACATGGAAAAACCCCTCTATTCCAAATGTT
CTCAGATGGCTGATAATGGAGAAAGATCACAGCAGTGTTCCAAGTTCTAAAGAGGAACTA
GACAAAGAACTCCCAGTGCTTAAGCCATATTTTATCACTAACCCTGAAGAAGCTGGAGTG
AGGGAAGCTGGCTTAAGAGTCACATGGCTGGGACATGCCACGGTAATGGTGGAAATGGAT
GAGCTCATATTTCTCACGGATCCCATCTTTAGCTCTCGTGCTTCACCATCGCAGTACATG
GGTCCAAAGCGATTTCGTCGTTCCCCGTGCACAATAAGTGAACTCCCTCCAATAGATGCG
GTCCTTATCAGTCACAACCACTATGACCATCTGGACTACAATTCTGTCATTGCTTTGAAT
GAGCGATTTGGTAATGAGTTGAGATGGTTTGTGCCTTTGGGTCTCCTTGACTGGATGCAA
AAATGTGGCTGTGAGAATGTGATTGAGTTGGACTGGTGGGAGGAGAATTGTGTCCCCGGA
CATGATAAGGTCACTTTTGTCTTTACACCTTCCCAGCACTGGTGTAAAAGGACTCTAATG
GATGACAACAAGGTGCTATGGGGCAGCTGGTCTGTCTTGGGGCCTTGGAATCGATTTTTT
TTCGCAGGAGATACTGGTTATTGCCCTGCTTTTGAAGAGATAGGAAAAAGATTTGGACCT
TTTGACCTTGCAGCTATTCCCATCGGAGCTTATGAACCGAGGTGGTTTATGAAATACCAG
CATGTAGACCCAGAAGAAGCTGTAAGGATTCACACTGATGTCCAAACAAAGAAATCTATG
GCAATTCACTGGGGAACTTTTGCCTTAGCAAATGAGCATTACTTAGAGCCTCCAGTGAAG
CTGAATGAAGCTCTAGAGAGATACGGACTTAACGCTGAAGATTTTTTTGTCTTGAAGCAT
GGAGAATCAAGATACCTAAATAATGATGATGAAAACTTTTAA
|
| Protein Properties |
|---|
| Number of Residues
| 393 |
| Molecular Weight
| 45595.15 |
| Theoretical pI
| 6.059 |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D
MDENESNQSLMTSSQYPKEAVRKRQNSARNSGASDSSRFSRKSFKLDYRLEEDVTKSKKG
KDGRFVNPWPTWKNPSIPNVLRWLIMEKDHSSVPSSKEELDKELPVLKPYFITNPEEAGV
REAGLRVTWLGHATVMVEMDELIFLTDPIFSSRASPSQYMGPKRFRRSPCTISELPPIDA
VLISHNHYDHLDYNSVIALNERFGNELRWFVPLGLLDWMQKCGCENVIELDWWEENCVPG
HDKVTFVFTPSQHWCKRTLMDDNKVLWGSWSVLGPWNRFFFAGDTGYCPAFEEIGKRFGP
FDLAAIPIGAYEPRWFMKYQHVDPEEAVRIHTDVQTKKSMAIHWGTFALANEHYLEPPVK
LNEALERYGLNAEDFFVLKHGESRYLNNDDENF
|
| External Links |
|---|
| GenBank ID Protein
| 38524476 |
| UniProtKB/Swiss-Prot ID
| Q6IQ20 |
| UniProtKB/Swiss-Prot Entry Name
| NAPEP_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB112352 |
| GeneCard ID
| NAPEPLD |
| GenAtlas ID
| NAPEPLD |
| HGNC ID
| HGNC:21683 |
| References |
|---|
| General References
| Not Available |