| Identification |
|---|
| HMDB Protein ID
| CDBP02541 |
| Secondary Accession Numbers
| Not Available |
| Name
| Abhydrolase domain-containing protein 4 |
| Description
| Not Available |
| Synonyms
|
- Alpha/beta-hydrolase 4
- Lyso-N-acylphosphatidylethanolamine lipase
|
| Gene Name
| ABHD4 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in hydrolase activity |
| Specific Function
| Lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE). Contributes to the biosynthesis of N-acyl ethanolamines, including the endocannabinoid anandamide by hydrolyzing the sn-1 and sn-2 acyl chains from N-acyl phosphatidylethanolamine (NAPE) generating glycerophospho-N-acyl ethanolamine (GP-NAE), an intermediate for N-acyl ethanolamine biosynthesis. Hydrolyzes substrates bearing saturated, monounsaturated, polyunsaturated N-acyl chains. Shows no significant activity towards other lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine and lysophosphatidylserine |
| GO Classification
|
Not Available
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.2 |
| SNPs
| ABHD4 |
| Gene Sequence
|
>1029 bp
ATGGCCGATGATCTGGAGCAGCAGTCTCAAGGCTGGCTGAGTAGCTGGCTGCCCACGTGG
CGCCCCACTTCCATGTCTCAGCTGAAGAATGTGGAAGCCAGGATCCTCCAGTGTCTCCAG
AATAAGTTCCTGGCCAGATATGTATCCCTCCCAAACCAGAATAAGATCTGGACGGTGACT
GTGAGCCCCGAGCAAAACGACCGCACCCCCTTGGTGATGGTGCATGGTTTTGGGGGCGGC
GTGGGTCTCTGGATCCTCAACATGGACTCACTGAGTGCCCGCCGCACACTGCACACCTTC
GATCTGCTTGGCTTCGGGCGAAGCTCAAGGCCAGCATTCCCAAGGGACCCGGAGGGGGCT
GAGGATGAGTTTGTGACATCGATAGAGACATGGCGGGAGACCATGGGGATCCCCAGCATG
ATCCTCCTGGGGCACAGTTTGGGAGGATTCCTGGCCACTTCTTACTCAATCAAGTACCCT
GATAGAGTTAAACACCTCATCCTGGTGGACCCATGGGGCTTTCCCCTCCGACCAACTAAC
CCCAGTGGGATCTGTGCACCCCCAGCCTGGGTCAAAGCCGTGGCATCTGTCCTAGGACGT
TCCAATCCATTGGCTGTTCTTCGAGTAGCTGGGCCCTGGGGGCCTGGTCTGGTGCAGCGA
TTCCGGCCGGACTTCAAACGCAAGTTTGCAGACTTCTTTGAAGATGATACCATATCAGAG
TATATTTACCACTGCAACGCACAGAATCCCAGTGGTGAGACAGCATTCAAAGCCATGATG
GAGTCCTTTGGCTGGGCCCGGCGCCCTATGCTGGAGCGAATTCACTTGATTCGAAAAGAT
GTGCCTATCACTATGATCTACGGGTCCGACACCTGGATAGATACCAGTACGGGAAAAAAG
GTGAAGATGCAGCGGCCGGATTCCTATGTCCGAGACATGGAGATTAAGGGTGCCTCCCAC
CATGTCTATGCTGACCAGCCACACATCTTCAATGCTGTGGTGGAGGAGATCTGCGACTCA
GTTGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 342 |
| Molecular Weight
| 38794.1 |
| Theoretical pI
| 7.69 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Abhydrolase domain-containing protein 4
MADDLEQQSQGWLSSWLPTWRPTSMSQLKNVEARILQCLQNKFLARYVSLPNQNKIWTVT
VSPEQNDRTPLVMVHGFGGGVGLWILNMDSLSARRTLHTFDLLGFGRSSRPAFPRDPEGA
EDEFVTSIETWRETMGIPSMILLGHSLGGFLATSYSIKYPDRVKHLILVDPWGFPLRPTN
PSEIRAPPAWVKAVASVLGRSNPLAVLRVAGPWGPGLVQRFRPDFKRKFADFFEDDTISE
YIYHCNAQNPSGETAFKAMMESFGWARRPMLERIHLIRKDVPITMIYGSDTWIDTSTGKK
VKMQRPDSYVRDMEIKGASHHVYADQPHIFNAVVEEICDSVD
|
| External Links |
|---|
| GenBank ID Protein
| 10434528 |
| UniProtKB/Swiss-Prot ID
| Q8TB40 |
| UniProtKB/Swiss-Prot Entry Name
| ABHD4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK022878 |
| GeneCard ID
| ABHD4 |
| GenAtlas ID
| ABHD4 |
| HGNC ID
| HGNC:20154 |
| References |
|---|
| General References
| Not Available |