| Identification |
|---|
| HMDB Protein ID
| CDBP02523 |
| Secondary Accession Numbers
| Not Available |
| Name
| 2-acylglycerol O-acyltransferase 3 |
| Description
| Not Available |
| Synonyms
|
- Acyl-CoA:monoacylglycerol acyltransferase 3
- Diacylglycerol O-acyltransferase candidate 7
- Diacylglycerol acyltransferase 2-like protein 7
- MGAT3
- Monoacylglycerol O-acyltransferase 3
- hDC7
|
| Gene Name
| MOGAT3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring acyl groups other than amino-acyl groups |
| Specific Function
| Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes.
|
| GO Classification
|
| Biological Process |
| glycerol metabolic process |
| triglyceride biosynthetic process |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring acyl groups |
| transferase activity, transferring acyl groups other than amino-acyl groups |
| Molecular Function |
| 2-acylglycerol O-acyltransferase activity |
| diacylglycerol O-acyltransferase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | triacylglycerol biosynthesis | Not Available | Not Available | | Fat digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7q22.1 |
| SNPs
| MOGAT3 |
| Gene Sequence
|
>1026 bp
ATGGGAGTTGCCACAACCCTGCAGCCCCCAACCACTTCCAAAACCTTGCAGAAGCAGCAT
CTAGAAGCAGTGGGCGCCTACCAATATGTGCTCACTTTCCTCTTCATGGGCCCTTTCTTC
TCCCTTCTTGTCTTTGTCCTCCTCTTCACGTCACTCTGGCCCTTCTCTGTTTTTTACTTG
GTGTGGCTCTATGTGGACTGGGACACACCCAACCAAGGTGGAAGGCGTTCGGAGTGGATA
AGGAACCGGGCAATTTGGAGACAACTAAGGGATTATTATCCTGTCAAGCTGGTGAAAACA
GCAGAGCTGCCCCCGGATCGGAACTACGTGCTGGGCGCCCACCCTCATGGGATCATGTGT
ACAGGCTTCCTCTGTAATTTCTCCACCGAGAGCAATGGCTTCTCCCAGCTCTTCCCGGGG
CTCCGGCCCTGGTTAGCCGTGCTGGCTGGCCTCTTCTACCTCCCGGTCTATCGCGACTAC
ATCATGTCCTTTGGACTCTGTCCGGTGAGCCGCCAGAGCCTGGACTTCATCCTGTCCCAG
CCCCAGCTCGGGCAGGCCGTGGTCATCATGGTGGGGGGTGCGCACGAGGCCCTGTATTCA
GTCCCCGGGGAGCACTGCCTTACGCTCCAGAAGCGCAAAGGCTTCGTGCGCCTGGCGCTG
AGGCACGGGGCGTCCCTGGTGCCCGTGTACTCCTTTGGGGAGAATGACATCTTTAGACTT
AAGGCTTTTGCCACAGGCTCCTGGCAGCATTGGTGCCAGCTCACCTTCAAGAAGCTCATG
GGCTTCTCTCCTTGCATCTTCTGGGGTCGCGGTCTCTTCTCAGCCACCTCCTGGGGCCTG
CTGCCCTTTGCTGTGCCCATCACCACTGTGGTGGGCCGCCCCATCCCCGTCCCCCAGCGC
CTCCACCCCACCGAGGAGGAAGTCAATCACTATCACGCCCTCTACATGACGGCCCTGGAG
CAGCTCTTCGAGGAGCACAAGGAAAGCTGTGGGGTCCCCGCTTCCACCTGCCTCACCTTC
ATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 341 |
| Molecular Weight
| 38729.84 |
| Theoretical pI
| 8.587 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>2-acylglycerol O-acyltransferase 3
MGVATTLQPPTTSKTLQKQHLEAVGAYQYVLTFLFMGPFFSLLVFVLLFTSLWPFSVFYL
VWLYVDWDTPNQGGRRSEWIRNRAIWRQLRDYYPVKLVKTAELPPDRNYVLGAHPHGIMC
TGFLCNFSTESNGFSQLFPGLRPWLAVLAGLFYLPVYRDYIMSFGLCPVSRQSLDFILSQ
PQLGQAVVIMVGGAHEALYSVPGEHCLTLQKRKGFVRLALRHGASLVPVYSFGENDIFRL
KAFATGSWQHWCQLTFKKLMGFSPCIFWGRGLFSATSWGLLPFAVPITTVVGRPIPVPQR
LHPTEEEVNHYHALYMTALEQLFEEHKESCGVPASTCLTFI
|
| External Links |
|---|
| GenBank ID Protein
| 29124967 |
| UniProtKB/Swiss-Prot ID
| Q86VF5 |
| UniProtKB/Swiss-Prot Entry Name
| MOGT3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY229854 |
| GeneCard ID
| MOGAT3 |
| GenAtlas ID
| MOGAT3 |
| HGNC ID
| HGNC:23249 |
| References |
|---|
| General References
| Not Available |