Cannabis Compound Database: Showing Protein Sn1-specific diacylglycerol lipase beta (CDBP02522)

Identification Biological properties Gene properties Protein properties External links References XML Show 17 compounds

Identification

HMDB Protein ID

CDBP02522

Secondary Accession Numbers

Not Available

Name

Sn1-specific diacylglycerol lipase beta

Description

Not Available

Synonyms

DGL-beta
KCCR13L

Gene Name

DAGLB

Protein Type

Enzyme

Biological Properties

General Function

Involved in triglyceride lipase activity

Specific Function

Catalyzes the hydrolysis of diacylglycerol (DAG) to 2- arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses

GO Classification

Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
triglyceride lipase activity
carboxylesterase activity
Process
lipid metabolic process
metabolic process
primary metabolic process

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:7

Locus

7p22.1

SNPs

DAGLB

Gene Sequence

>2019 bp
ATGCCGGGGATGGTACTCTTCGGCCGGCGCTGGGCCATCGCCAGCGACGACTTGGTCTTC
CCAGGGTTCTTCGAGCTGGTCGTGCGAGTGCTGTGGTGGATTGGCATTCTGACGTTGTAT
CTCATGCACAGAGGAAAGCTGGACTGTGCTGGTGGAGCCTTGCTCAGCAGTTACTTGATC
GTCCTCATGATTCTCCTGGCAGTTGTCATATGTACTGTGTCAGCCATCATGTGTGTCAGC
ATGAGAGGAACGATTTGTAACCCTGGACCGCGGAAGTCTATGTCTAAGCTGCTTTACATC
CGCCTGGCGCTGTTTTTTCCAGAGATGGTCTGGGCCTCTCTGGGGGCTGCCTGGGTGGCA
GATGGTGTTCAGTGCGACAGGACAGTTGTAAACGGCATCATCGCAACCGTCGTGGTCAGT
TGGATCATCATCGCTGCCACAGTGGTTTCCATTATCATTGTCTTTGACCCTCTTGGGGGG
AAAATGGCTCCATATTCCTCTGCCGGCCCCAGCCACCTGGATAGTCATGATTCAAGCCAG
TTACTTAATGGCCTCAAGACAGCAGCTACAAGCGTGTGGGAAACCAGAATCAAGCTCTTG
TGCTGTTGCATTGGGAAAGACGACCATACTCGGGTTGCTTTTTCGAGTACGGCAGAGCTT
TTCTCAACCTACTTTTCAGACACAGATCTGGTGCCCAGCGACATTGCGGCGGGCCTCGCC
CTGCTTCATCAGCAACAGGACAATATCAGGAACAACCAAGAGCCTGCCCAGGTGGTCTGC
CATGCCCCAGGGAGCTCCCAGGAAGCTGATCTGGATGCAGAATTAGAAAACTGCCATCAT
TACATGCAGTTTGCAGCAGCGGCCTATGGGTGGCCCCTCTACATCTACAGAAACCCCCTC
ACGGGGCTGTGCAGGATTGGTGGTGACTGCTGCAGAAGCAGAACCACAGACTATGACTTG
GTCGGAGGCGATCAGCTCAACTGTCACTTCGGCTCCATCCTGCACACCACAGGGCTGCAG
TACAGGGACTTCATCCACGTCAGCTTCCATGACAAGGTTTACGAGCTGCCGTTTTTAGTG
GCTCTGGATCACAGGAAAGAGTCTGTTGTGGTCGCTGTGAGGGGGACCATGTCTCTGCAG
GATGTCCTTACGGACCTGTCAGCGGAGAGTGAGGTGCTGGACGTGGAGTGTGAGGTGCAG
GACCGCCTGGCACACAAGGGTATTTCTCAAGCTGCCAGATACGTTTACCAACGACTCATC
AACGACGGGATTTTGAGCCAAGCCTTCAGCATTGCTCCTGAGTACCGGCTGGTCATAGTG
GGCCACAGCCTCGGGGGCGGGGCGGCCGCCCTGCTGGCCACCATGCTCAGAGCCGCCTAC
CCGCAGGTCAGGTGCTACGCCTTCTCCCCACCCCGGGGGCTGTGGAGCAAAGCTCTGCAG
GAATATTCTCAGAGCTTCATCGTGTCACTCGTCCTGGGGAAGGATGTGATTCCCAGGCTC
AGTGTGACCAACTTGGAAGATCTGAAGAGAAGAATCTTGCGAGTGGTCGCGCACTGCAAT
AAACCCAAGTACAAGATCTTGCTGCACGGTTTGTGGTACGAACTGTTTGGAGGAAACCCC
AACAACTTGCCCACGGAGCTGGACGGGGGCGACCAGGAAGTCCTGACACAGCCTCTTCTG
GGGGAGCAGAGCCTACTGACGCGCTGGTCCCCGGCCTACAGCTTCTCCAGCGACTCTCCA
CTGGACTCTTCTCCCAAGTACCCCCCTCTCTACCCTCCCGGCAGGATCATCCACCTGCAG
GAGGAGGGCGCCTCGGGGCGGTTTGGCTGCTGCTCTGCTGCTCACTATAGCGCCAAGTGG
TCACACGAAGCGGAATTCAGCAAAATACTCATAGGTCCGAAGATGCTCACCGACCACATG
CCAGACATCCTGATGCGGGCCTTGGACAGCGTGGTCTCCGACAGAGCGGCCTGCGTCTCC
TGTCCAGCACAAGGGGTCTCCAGTGTGGACGTGGCCTGA

Protein Properties

Number of Residues

672

Molecular Weight

73731.3

Theoretical pI

6.54

Pfam Domain Function

Lipase_3 (PF01764 )

Signals

["None"]

Transmembrane Regions

["18-38", "59-79", "103-123", "133-153"]

Protein Sequence

>Sn1-specific diacylglycerol lipase beta
MPGMVLFGRRWAIASDDLVFPGFFELVVRVLWWIGILTLYLMHRGKLDCAGGALLSSYLI
VLMILLAVVICTVSAIMCVSMRGTICNPGPRKSMSKLLYIRLALFFPEMVWASLGAAWVA
DGVQCDRTVVNGIIATVVVSWIIIAATVVSIIIVFDPLGGKMAPYSSAGPSHLDSHDSSQ
LLNGLKTAATSVWETRIKLLCCCIGKDDHTRVAFSSTAELFSTYFSDTDLVPSDIAAGLA
LLHQQQDNIRNNQEPAQVVCHAPGSSQEADLDAELENCHHYMQFAAAAYGWPLYIYRNPL
TGLCRIGGDCCRSRTTDYDLVGGDQLNCHFGSILHTTGLQYRDFIHVSFHDKVYELPFLV
ALDHRKESVVVAVRGTMSLQDVLTDLSAESEVLDVECEVQDRLAHKGISQAARYVYQRLI
NDGILSQAFSIAPEYRLVIVGHSLGGGAAALLATMLRAAYPQVRCYAFSPPRGLWSKALQ
EYSQSFIVSLVLGKDVIPRLSVTNLEDLKRRILRVVAHCNKPKYKILLHGLWYELFGGNP
NNLPTELDGGDQEVLTQPLLGEQSLLTRWSPAYSFSSDSPLDSSPKYPPLYPPGRIIHLQ
EEGASGRFGCCSAAHYSAKWSHEAEFSKILIGPKMLTDHMPDILMRALDSVVSDRAACVS
CPAQGVSSVDVA

External Links

GenBank ID Protein

17864023

UniProtKB/Swiss-Prot ID

Q8NCG7

UniProtKB/Swiss-Prot Entry Name

DGLB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF450090

GeneCard ID