Cannabis Compound Database: Showing Protein Cytochrome b5 reductase 4 (CDBP02507)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP02507

Secondary Accession Numbers

Not Available

Name

Cytochrome b5 reductase 4

Description

Not Available

Synonyms

Flavohemoprotein b5/b5R
N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein
b5+b5R
cb5/cb5R

Gene Name

CYB5R4

Protein Type

Enzyme

Biological Properties

General Function

Involved in heme binding

Specific Function

NADH-cytochrome b5 reductase involved in endoplasmic reticulum stress response pathway. Plays a critical role in protecting pancreatic beta-cells against oxidant stress, possibly by protecting the cell from excess buildup of reactive oxygen species (ROS). Reduces a variety of substrates in vitro, such as cytochrome c, feericyanide and methemoglobin.

GO Classification

Biological Process
superoxide metabolic process
cell development
detection of oxygen
generation of precursor metabolites and energy
glucose homeostasis
insulin secretion
response to antibiotic
Cellular Component
endoplasmic reticulum
perinuclear region of cytoplasm
Function
heme binding
oxidoreductase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
iron ion binding
Molecular Function
metal ion binding
cytochrome-b5 reductase activity
heme binding
NAD(P)H oxidase activity
Process
metabolic process
oxidation reduction

Cellular Location

Endoplasmic reticulum

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

6pter-q22.33

SNPs

CYB5R4

Gene Sequence

>1566 bp
ATGCTGAACGTCCCTTCCCAGTCTTTCCCGGCCCCCAGGTCGCAGCAGCGTGTCGCCTCC
GGGGGGCGTAGCAAGGTACCTTTAAAACAGGGCAGAAGCCTTATGGATTGGATTCGACTG
ACCAAAAGTGGAAAGGATCTAACGGGATTAAAAGGCAGGTTAATTGAAGTAACTGAAGAA
GAACTTAAGAAACACAACAAAAAAGATGATTGTTGGATATGCATAAGAGGTTTCGTTTAT
AATGTCAGCCCTTATATGGAGTATCATCCTGGTGGAGAAGATGAACTAATGAGAGCAGCA
GGATCAGATGGTACTGAACTTTTTGATCAGGTTCATCGTTGGGTCAATTATGAATCCATG
CTGAAAGAATGCCTGGTTGGCAGAATGGCCATTAAACCTGCTGTTCTGAAAGACTATCGT
GAGGAGGAAAAGAAAGTCTTAAATGGCATGCTTCCCAAGAGCCAAGTGACAGATACACTT
GCCAAAGAAGGTCCTAGTTATCCAAGCTATGATTGGTTCCAAACAGACTCTTTAGTCACC
ATTGCCATATATACTAAACAGAAGGATATCAATTTAGACTCAATAATAGTTGATCATCAG
AATGATTCCTTTAGAGCAGAAACAATTATTAAGGATTGTTTATATCTTATACATATTGGG
CTAAGCCATGAGGTTCAGGAAGATTTTTCTGTGCGGGTTGTTGAGAGTGTGGGAAAAATA
GAGATTGTTCTACAAAAAAAAGAGAATACTTCTTGGGACTTTCTTGGCCATCCCCTGAAG
AATCATAATTCACTTATTCCAAGGAAAGATACAGGTTTGTACTACAGAAAGTGCCAGTTA
ATTTCCAAGGAAGATGTTACTCATGATACGAGGCTTTTCTGTTTGATGCTGCCACCAAGC
ACTCATCTTCAAGTGCCCATTGGGCAACATGTTTACCTCAAGCTACCTATTACAGGTACA
GAAATAGTAAAGCCATATACACCTGTATCTGGTTCCTTACTCTCAGAGTTCAAGGAACCA
GTTCTTCCCAACAATAAATACATCTACTTTTTGATAAAAATCTATCCCACTGGACTCTTC
ACACCAGAGCTTGATCGTCTTCAGATTGGAGATTTTGTTTCTGTAAGCAGTCCTGAGGGC
AATTTTAAAATATCCAAGTTCCAAGAATTAGAAGATCTCTTTTTGTTGGCAGCTGGAACA
GGCTTCACACCAATGGTTAAAATACTGAATTATGCTTTGACTGATATACCCAGTCTCAGG
AAAGTGAAGCTGATGTTCTTCAATAAAACAGAAGATGATATAATTTGGAGAAGCCAATTG
GAGAAATTAGCATTTAAAGATAAAAGACTGGATGTTGAATTTGTTCTCTCAGCACCTATT
TCTGAATGGAATGGCAAACAGGGACATATTTCACCAGCTCTTCTTTCTGAATTTTTGAAA
AGAAATTTGGACAAATCCAAAGTTCTCGTCTGCATTTGTGGACCAGTGCCATTTACAGAA
CAAGGAGTAAGGTTGCTGCATGATCTCAACTTTTCCAAAAATGAGATCCATAGTTTTACA
GCATAA

Protein Properties

Number of Residues

521

Molecular Weight

59473.19

Theoretical pI

7.724

Pfam Domain Function

FAD_binding_6 (PF00970 )
NAD_binding_1 (PF00175 )
Cyt-b5 (PF00173 )
CS (PF04969 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cytochrome b5 reductase 4
MLNVPSQSFPAPRSQQRVASGGRSKVPLKQGRSLMDWIRLTKSGKDLTGLKGRLIEVTEE
ELKKHNKKDDCWICIRGFVYNVSPYMEYHPGGEDELMRAAGSDGTELFDQVHRWVNYESM
LKECLVGRMAIKPAVLKDYREEEKKVLNGMLPKSQVTDTLAKEGPSYPSYDWFQTDSLVT
IAIYTKQKDINLDSIIVDHQNDSFRAETIIKDCLYLIHIGLSHEVQEDFSVRVVESVGKI
EIVLQKKENTSWDFLGHPLKNHNSLIPRKDTGLYYRKCQLISKEDVTHDTRLFCLMLPPS
THLQVPIGQHVYLKLPITGTEIVKPYTPVSGSLLSEFKEPVLPNNKYIYFLIKIYPTGLF
TPELDRLQIGDFVSVSSPEGNFKISKFQELEDLFLLAAGTGFTPMVKILNYALTDIPSLR
KVKLMFFNKTEDDIIWRSQLEKLAFKDKRLDVEFVLSAPISEWNGKQGHISPALLSEFLK
RNLDKSKVLVCICGPVPFTEQGVRLLHDLNFSKNEIHSFTA

External Links

GenBank ID Protein

84875541

UniProtKB/Swiss-Prot ID

Q7L1T6

UniProtKB/Swiss-Prot Entry Name

NB5R4_HUMAN

PDB IDs