| Identification |
|---|
| HMDB Protein ID
| CDBP02506 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH-cytochrome b5 reductase 2 |
| Description
| Not Available |
| Synonyms
|
- b5R.2
|
| Gene Name
| CYB5R2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity). Responsible for NADH-dependent lucigenin chemiluminescence in spermatozoa by reducing both lucigenin and 2-[4-iodophenyl]-3-[4-nitrophenyl]-5-[2,4-disulfophenyl]-2H tetrazolium monosodium salt (WST-1).
|
| GO Classification
|
| Biological Process |
| sterol biosynthetic process |
| Cellular Component |
| mitochondrion |
| membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| cytochrome-b5 reductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino sugar and nucleotide sugar metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 11 |
| Locus
| 11p15.4 |
| SNPs
| CYB5R2 |
| Gene Sequence
|
>831 bp
ATGAACTCCAGGAGGAGAGAGCCAATCACCTTACAGGACCCTGAAGCCAAGTACCCGCTG
CCATTGATTGAGAAAGAGAAAATCAGCCACAACACCCGGAGGTTCCGCTTTGGACTGCCT
TCGCCGGACCATGTCTTAGGGCTTCCTGTAGGTAACTATGTCCAGCTCTTGGCAAAAATC
GATAATGAATTGGTGGTCAGGGCTTACACCCCTGTCTCCAGTGATGATGACAGAGGCTTT
GTGGACCTAATTATAAAGATCTACTTCAAAAATGTACACCCCCAATATCCTGAAGGTGGG
AAGATGACTCAGTATTTGGAGAACATGAAAATCGGGGAGACCATCTTTTTTCGAGGCCCA
AGGGGACGCTTGTTTTACCATGGGCCACGGAATCTTGGAATCAGACCAGACCAGACGAGT
GAGCCTAAAAAAACACTGGCCGATCACCTGGGAATGATTGCTGGGGGCACAGGCATCACA
CCCATGTTGCAGCTCATTCGCCACATCACCAAGGACCCCAGTGACAGGACCAGGATGTCC
CTCATCTTTGCCAACCAGACAGAGGAGGATATCTTGGTCAGAAAAGAGCTTGAAGAAATT
GCCAGGACTCACCCAGACCAGTTCGACCTGTGGTACACCCTGGACAGGCCTCCCATTGGC
TGGAAGTACAGCTCAGGCTTCGTTACTGCCGACATGATCAAGGAGCACCTTCCTCCTCCA
GCGAAGTCCACGCTCATCCTGGTGTGTGGCCCGCCAACACTGATCCAGACGGCGGCTCAC
CCTAACCTGGAGAAGCTGGGTTATACCCAGGACATGATTTTCACCTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 276 |
| Molecular Weight
| 31457.995 |
| Theoretical pI
| 8.5 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADH-cytochrome b5 reductase 2
MNSRRREPITLQDPEAKYPLPLIEKEKISHNTRRFRFGLPSPDHVLGLPVGNYVQLLAKI
DNELVVRAYTPVSSDDDRGFVDLIIKIYFKNVHPQYPEGGKMTQYLENMKIGETIFFRGP
RGRLFYHGPGNLGIRPDQTSEPKKTLADHLGMIAGGTGITPMLQLIRHITKDPSDRTRMS
LIFANQTEEDILVRKELEEIARTHPDQFNLWYTLDRPPIGWKYSSGFVTADMIKEHLPPP
AKSTLILVCGPPPLIQTAAHPNLEKLGYTQDMIFTY
|
| External Links |
|---|
| GenBank ID Protein
| 6166390 |
| UniProtKB/Swiss-Prot ID
| Q6BCY4 |
| UniProtKB/Swiss-Prot Entry Name
| NB5R2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF169802 |
| GeneCard ID
| CYB5R2 |
| GenAtlas ID
| CYB5R2 |
| HGNC ID
| HGNC:24376 |
| References |
|---|
| General References
| Not Available |