| Identification |
|---|
| HMDB Protein ID
| CDBP02505 |
| Secondary Accession Numbers
| Not Available |
| Name
| NADH-cytochrome b5 reductase 1 |
| Description
| Not Available |
| Synonyms
|
- Humb5R2
- NAD(P)H:quinone oxidoreductase type 3 polypeptide A2
- b5R.1
|
| Gene Name
| CYB5R1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| NADH-cytochrome b5 reductases are involved in desaturation and elongation of fatty acids, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction (By similarity).
|
| GO Classification
|
| Biological Process |
| sterol biosynthetic process |
| Cellular Component |
| mitochondrion |
| integral to membrane |
| Function |
| catalytic activity |
| oxidoreductase activity |
| Molecular Function |
| cytochrome-b5 reductase activity |
| Process |
| oxidation reduction |
| metabolic process |
|
| Cellular Location
|
- Membrane
- Single-pass membrane protein (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Amino sugar and nucleotide sugar metabolism | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1q32.1 |
| SNPs
| CYB5R1 |
| Gene Sequence
|
>918 bp
ATGGGGATCCAGACGAGCCCCGTCCTGCTGGCCTCCCTGGGGGTGGGGCTGGTCACTCTG
CTCGGCCTGGCTGTGGGCTCCTACTTGGTTCGGAGGTCCCGCCGGCCTCAGGTCACTCTC
CTGGACCCCAATGAAAAGTACCTGCTACGACTGCTAGACAAGACGACTGTGAGCCACAAC
ACCAAGAGGTTCCGCTTTGCCCTGCCCACCGCCCACCACACTCTGGGGCTGCCTGTGGGC
AAACATATCTACCTCTCCACCCGAATTGATGGCAGCCTGGTCATCAGGCCATACACTCCT
GTCACCAGTGATGAGGATCAAGGCTATGTGGATCTTGTCATCAAGGTCTACCTGAAGGGT
GTGCACCCCAAATTTCCTGAGGGAGGGAAGATGTCTCAGTACCTGGATAGCCTGAAGGTT
GGGGATGTGGTGGAGTTTCGGGGGCCAAGCGGGTTGCTCACTTACACTGGAAAAGGGCAT
TTTAACATTCAGCCCAACAAGAAATCTCCACCAGAACCCCGAGTGGCGAAGAAACTGGGA
ATGATTGCCGGCGGGACAGGAATCACCCCAATGCTACAGCTGATCCGGGCCATCCTGAAA
GTCCCTGAAGATCCAACCCAGTGCTTTCTGCTTTTTGCCAACCAGACAGAAAAGGATATC
ATCTTGCGGGAGGACTTAGAGGAACTGCAGGCCCGCTATCCCAATCGCTTTAAGCTCTGG
TTCACTCTGGATCATCCCCCAAAAGATTGGGCCTACAGCAAGGGCTTTGTGACTGCCGAC
ATGATCCGGGAACACCTGCCCGCTCCAGGGGATGATGTGCTGGTACTGCTTTGTGGGCCA
CCCCCAATGGTGCAGCTGGCCTGCCATCCCAACTTGGACAAACTGGGCTACTCACAAAAG
ATGCGATTCACCTACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 305 |
| Molecular Weight
| 34094.57 |
| Theoretical pI
| 9.378 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>NADH-cytochrome b5 reductase 1
MGIQTSPVLLASLGVGLVTLLGLAVGSYLVRRSRRPQVTLLDPNEKYLLRLLDKTTVSHN
TKRFRFALPTAHHTLGLPVGKHIYLSTRIDGSLVIRPYTPVTSDEDQGYVDLVIKVYLKG
VHPKFPEGGKMSQYLDSLKVGDVVEFRGPSGLLTYTGKGHFNIQPNKKSPPEPRVAKKLG
MIAGGTGITPMLQLIRAILKVPEDPTQCFLLFANQTEKDIILREDLEELQARYPNRFKLW
FTLDHPPKDWAYSKGFVTADMIREHLPAPGDDVLVLLCGPPPMVQLACHPNLDKLGYSQK
MRFTY
|
| External Links |
|---|
| GenBank ID Protein
| 33150662 |
| UniProtKB/Swiss-Prot ID
| Q9UHQ9 |
| UniProtKB/Swiss-Prot Entry Name
| NB5R1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF087912 |
| GeneCard ID
| CYB5R1 |
| GenAtlas ID
| CYB5R1 |
| HGNC ID
| HGNC:13397 |
| References |
|---|
| General References
| Not Available |