Cannabis Compound Database: Showing Protein Glycerol-3-phosphate dehydrogenase 1-like protein (CDBP02503)

Identification Biological properties Gene properties Protein properties External links References XML Show 5 compounds

Identification

HMDB Protein ID

CDBP02503

Secondary Accession Numbers

Not Available

Name

Glycerol-3-phosphate dehydrogenase 1-like protein

Description

Not Available

Synonyms

GPD1-L

Gene Name

GPD1L

Protein Type

Enzyme

Biological Properties

General Function

Involved in oxidoreductase activity

Specific Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

GO Classification

Biological Process
regulation of ventricular cardiac muscle cell action potential
regulation of ventricular cardiac muscle cell membrane depolarization
phosphatidic acid biosynthetic process
triglyceride biosynthetic process
carbohydrate metabolic process
glycerol-3-phosphate catabolic process
NAD metabolic process
negative regulation of peptidyl-serine phosphorylation
negative regulation of protein kinase C signaling cascade
positive regulation of protein localization to cell surface
positive regulation of sodium ion transport
regulation of heart rate
regulation of sodium ion transmembrane transporter activity
Cellular Component
cytosol
plasma membrane
glycerol-3-phosphate dehydrogenase complex
Component
cell part
intracellular part
cytoplasm
macromolecular complex
protein complex
glycerol-3-phosphate dehydrogenase complex
Function
coenzyme binding
cofactor binding
oxidoreductase activity, acting on ch-oh group of donors
oxidoreductase activity
identical protein binding
protein homodimerization activity
glycerol-3-phosphate dehydrogenase [nad+] activity
binding
nucleotide binding
catalytic activity
nad or nadh binding
oxidoreductase activity, acting on the ch-oh group of donors, nad or nadp as acceptor
protein binding
Molecular Function
NAD binding
glycerol-3-phosphate dehydrogenase [NAD+] activity
sodium channel regulator activity
Process
alditol metabolic process
glycerol metabolic process
glycerol-3-phosphate metabolic process
oxidation reduction
glycerol-3-phosphate catabolic process
metabolic process
primary metabolic process
carbohydrate metabolic process
small molecule metabolic process
alcohol metabolic process
polyol metabolic process

Cellular Location

Cytoplasm

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerophospholipid metabolism	Not Available

Gene Properties

Chromosome Location

Locus

3p22.3

SNPs

GPD1L

Gene Sequence

>1056 bp
ATGGCAGCGGCGCCCCTGAAAGTGTGCATCGTGGGCTCGGGGAACTGGGGTTCAGCTGTT
GCAAAAATAATTGGTAATAATGTCAAGAAACTTCAGAAATTTGCCTCCACAGTCAAGATG
TGGGTCTTTGAAGAAACAGTGAATGGCAGAAAACTGACAGACATCATAAATAATGACCAT
GAAAATGTAAAATATCTTCCTGGACACAAGCTGCCAGAAAATGTGGTTGCCATGTCAAAT
CTTAGCGAGGCTGTGCAGGATGCAGACCTGCTGGTGTTTGTCATTCCCCACCAGTTCATT
CACAGAATCTGTGATGAGATCACTGGGAGAGTGCCCAAGAAAGCGCTGGGAATCACCCTC
ATCAAGGGCATAGACGAGGGCCCCGAGGGGCTGAAGCTCATTTCTGACATCATCCGTGAG
AAGATGGGTATTGACATCAGTGTGCTGATGGGAGCCAACATTGCCAATGAGGTGGCTGCA
GAGAAGTTCTGTGAGACCACCATCGGCAGCAAAGTAATGGAGAACGGCCTTCTCTTCAAA
GAACTTCTGCAGACTCCAAATTTTCGAATTACCGTGGTTGATGATGCAGACACTGTTGAA
CTCTGTGGTGCGCTTAAGAACATCGTAGCTGTGGGAGCTGGGTTCTGCGACGGCCTCCGC
TGTGGAGACAACACCAAAGCGGCCGTCATCCGCCTGGGACTCATGGAAATGATTGCTTTT
GCCAGGATCTTCTGCAAAGGCCAAGTGTCTACAGCCACCTTCCTAGAGAGCTGCGGGGTG
GCCGACCTGATCACCACCTGTTACGGAGGGCGGAACCGCAGGGTGGCCGAGGCCTTCGCC
AGAACTGGGAAGACCATTGAAGAGTTGGAGAAGGAGATGCTGAATGGGCAAAAGCTCCAA
GGACCGCAGACTTCTGCTGAAGTGTACCGCATCCTCAAACAGAAGGGACTACTGGACAAG
TTTCCATTGTTTACTGCAGTGTATCAGATCTGCTACGAAAGCAGACCAGTTCAAGAGATG
TTGTCTTGTCTTCAGAGCCATCCAGAGCATACATAA

Protein Properties

Number of Residues

351

Molecular Weight

38418.44

Theoretical pI

7.023

Pfam Domain Function

NAD_Gly3P_dh_C (PF07479 )
NAD_Gly3P_dh_N (PF01210 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glycerol-3-phosphate dehydrogenase 1-like protein
MAAAPLKVCIVGSGNWGSAVAKIIGNNVKKLQKFASTVKMWVFEETVNGRKLTDIINNDH
ENVKYLPGHKLPENVVAMSNLSEAVQDADLLVFVIPHQFIHRICDEITGRVPKKALGITL
IKGIDEGPEGLKLISDIIREKMGIDISVLMGANIANEVAAEKFCETTIGSKVMENGLLFK
ELLQTPNFRITVVDDADTVELCGALKNIVAVGAGFCDGLRCGDNTKAAVIRLGLMEMIAF
ARIFCKGQVSTATFLESCGVADLITTCYGGRNRRVAEAFARTGKTIEELEKEMLNGQKLQ
GPQTSAEVYRILKQKGLLDKFPLFTAVYQICYESRPVQEMLSCLQSHPEHT

External Links

GenBank ID Protein

158259077

UniProtKB/Swiss-Prot ID

Q8N335

UniProtKB/Swiss-Prot Entry Name

GPD1L_HUMAN

PDB IDs