Cannabis Compound Database: Showing Protein Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (CDBP02487)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP02487

Secondary Accession Numbers

Not Available

Name

Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1

Description

Not Available

Synonyms

B3Gal-T8
Beta-1,3-galactosyltransferase
C1GalT1
Core 1 O-glycan T-synthase
Core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1
Core 1 beta1,3-galactosyltransferase 1
Core 1 beta3-Gal-T1

Gene Name

C1GALT1

Protein Type

Enzyme

Biological Properties

General Function

Involved in transferase activity, transferring glycosyl groups

Specific Function

Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Plays a central role in many processes, such as angiogenesis, thrombopoiesis and kidney homeostasis development.

GO Classification

Biological Process
O-glycan processing
post-translational protein modification
angiogenesis
cell differentiation
kidney development
Cellular Component
integral to membrane
Golgi membrane
Component
membrane
cell part
Function
catalytic activity
transferase activity
transferase activity, transferring glycosyl groups
Molecular Function
metal ion binding
glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity

Cellular Location

Membrane
Single-pass type II membrane protein

Pathways

Name	SMPDB/Pathwhiz	KEGG
protein glycosylation	Not Available	Not Available
Mucin type O-Glycan biosynthesis	Not Available

Gene Properties

Chromosome Location

Locus

7p21.3

SNPs

C1GALT1

Gene Sequence

>1092 bp
ATGGCCTCTAAATCCTGGCTGAATTTTTTAACCTTCCTCTGTGGATCAGCAATAGGATTT
CTTTTATGTTCTCAGCTATTTAGTATTTTGTTGGGAGAAAAGGTTGACACCCAGCCTAAT
GTTCTTCATAATGATCCTCATGCAAGGCATTCAGATGATAATGGACAGAATCATCTAGAA
GGACAAATGAACTTCAATGCAGATTCTAGCCAACATAAAGATGAGAACACAGACATTGCT
GAAAACCTCTATCAGAAAGTTAGAATTCTTTGCTGGGTTATGACCGGCCCTCAAAACCTA
GAGAAAAAGGCCAAACACGTCAAAGCTACTTGGGCCCAGCGTTGTAACAAAGTGTTGTTT
ATGAGTTCAGAAGAAAATAAAGACTTCCCTGCTGTGGGACTGAAAACCAAAGAAGGCAGA
GATCAACTATACTGGAAAACAATTAAAGCTTTTCAGTATGTTCATGAACATTATTTAGAA
GATGCTGATTGGTTTTTGAAAGCAGATGATGACACGTATGTCATACTAGACAATTTGAGG
TGGCTTCTTTCAAAATACGACCCTGAAGAACCCATTTACTTTGGGAGAAGATTTAAGCCT
TATGTAAAGCAGGGCTACATGAGTGGAGGAGCAGGATATGTACTAAGCAAAGAAGCCTTG
AAAAGATTTGTTGATGCATTTAAAACAGACAAGTGTACACATAGTTCCTCCATTGAAGAC
TTAGCACTGGGGAGATGCATGGAAATTATGAATGTAGAAGCAGGAGATTCCAGAGATACC
ATTGGAAAAGAAACTTTTCATCCCTTTGTGCCAGAACACCATTTAATTAAAGGTTATCTA
CCTAGAACGTTTTGGTACTGGAATTACAACTATTATCCTCCTGTAGAGGGTCCTGGTTGC
TGCTCTGATCTTGCAGTTTCTTTTCACTATGTTGATTCTACAACCATGTATGAGTTAGAA
TACCTCGTTTATCATCTTCGTCCATATGGTTATTTATACAGATATCAACCTACCTTACCT
GAACGTATACTAAAGGAAATTAGTCAAGCAAACAAAAATGAAGATACAAAAGTGAAGTTA
GGAAATCCTTGA

Protein Properties

Number of Residues

363

Molecular Weight

42202.5

Theoretical pI

6.638

Pfam Domain Function

Fringe (PF02434 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1
MASKSWLNFLTFLCGSAIGFLLCSQLFSILLGEKVDTQPNVLHNDPHARHSDDNGQNHLE
GQMNFNADSSQHKDENTDIAENLYQKVRILCWVMTGPQNLEKKAKHVKATWAQRCNKVLF
MSSEENKDFPAVGLKTKEGRDQLYWKTIKAFQYVHEHYLEDADWFLKADDDTYVILDNLR
WLLSKYDPEEPIYFGRRFKPYVKQGYMSGGAGYVLSKEALKRFVDAFKTDKCTHSSSIED
LALGRCMEIMNVEAGDSRDTIGKETFHPFVPEHHLIKGYLPRTFWYWNYNYYPPVEGPGC
CSDLAVSFHYVDSTTMYELEYLVYHLRPYGYLYRYQPTLPERILKEISQANKNEDTKVKL
GNP

External Links

GenBank ID Protein

37674437

UniProtKB/Swiss-Prot ID

Q9NS00

UniProtKB/Swiss-Prot Entry Name

C1GLT_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AC005532

GeneCard ID