| Identification |
|---|
| HMDB Protein ID
| CDBP02485 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium/hydrogen exchanger 4 |
| Description
| Not Available |
| Synonyms
|
- NHE-4
- Na(+)/H(+) exchanger 4
- Solute carrier family 9 member 4
|
| Gene Name
| SLC9A4 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in solute:hydrogen antiporter activity |
| Specific Function
| Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction. May play a specialized role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage. Is relatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner. Activated by 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS) in a sustained intracellular acidification-dependence manner. Affects potassium/proton exchange as well as sodium/proton and lithium/proton exchange. In basolateral cell membrane, participates in homeostatic control of intracellular pH, and may play a role in proton extrusion in order to achieve transepithelial HCO3(-) secretion. In apical cell membrane may be involved in mediating sodium absorption. Requires for normal levels of gastric acid secretion, secretory membrane development, parietal cell maturation and/or differentiation and at least secondarily for chief cell differentiation |
| GO Classification
|
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| monovalent cation:hydrogen antiporter activity |
| sodium:hydrogen antiporter activity |
| solute:cation antiporter activity |
| solute:hydrogen antiporter activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| cation transmembrane transporter activity |
| inorganic cation transmembrane transporter activity |
| monovalent inorganic cation transmembrane transporter activity |
| hydrogen ion transmembrane transporter activity |
| transporter activity |
| Process |
| sodium ion transport |
| establishment of localization |
| transport |
| biological regulation |
| transmembrane transport |
| monovalent inorganic cation transport |
| ion transport |
| cation transport |
| regulation of biological quality |
| homeostatic process |
| chemical homeostasis |
| ion homeostasis |
| cation homeostasis |
| monovalent inorganic cation homeostasis |
| regulation of ph |
|
| Cellular Location
|
- Multi-pass membrane protein
- Multi-pass membrane protein
- Multi-pass membrane protein
- Basolateral cell membrane
- Apical cell membrane
- Cytoplasmic granule membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2q12.1 |
| SNPs
| SLC9A4 |
| Gene Sequence
|
>2397 bp
ATGGCTCTGCAGATGTTCGTGACTTACAGTCCTTGGAATTGTTTGCTACTGCTAGTGGCT
CTTGAGTGTTCTGAAGCATCTTCTGATTTGAATGAATCTGCAAATTCCACTGCTCAGTAT
GCATCTAACGCTTGGTTTGCTGCTGCCAGCTCAGAGCCAGAGGAAGGGATATCTGTTTTT
GAACTGGATTATGACTATGTGCAAATTCCTTATGAGGTCACTCTCTGGATACTTCTAGCA
TCCCTTGCAAAAATAGGCTTCCACCTCTACCACAGGCTGCCAGGCCTCATGCCAGAAAGC
TGCCTCCTCATCCTGGTGGGGGCGCTGGTGGGCGGCATCATCTTCGGCACCGACCACAAA
TCGCCTCCGGTCATGGACTCCAGCATCTACTTCCTGTATCTCCTGCCACCCATCGTTCTG
GAGGGCGGCTACTTCATGCCCACCCGGCCCTTCTTTGAGAACATCGGCTCCATCCTGTGG
TGGGCAGTATTGGGGGCCCTGATCAACGCCTTGGGCATTGGCCTCTCCCTCTACCTCATC
TGCCAGGTGAAGGCCTTTGGCCTGGGCGACGTCAACCTGCTGCAGAACCTGCTGTTCGGC
AGCCTGATCTCCGCCGTGGACCCAGTGGCCGTGCTAGCCGTGTTTGAGGAAGCGCGCGTG
AACGAGCAGCTCTACATGATGATCTTTGGGGAGGCCCTGCTCAATGATGGCATTACTGTG
GTCTTATACAATATGTTAATTGCCTTTACAAAGATGCATAAATTTGAAGACATAGAAACT
GTCGACATTTTGGCTGGATGTGCCCGATTCATCGTTGTGGGGCTTGGAGGGGTATTGTTT
GGCATCGTTTTTGGATTTATTTCTGCATTTATCACACGTTTCACTCAGAATATCTCTGCA
ATTGAGCCACTCATCGTCTTCATGTTCAGCTATTTGTCTTACTTAGCTGCTGAAACCCTC
TATCTCTCCGGCATCCTGGCAATCACAGCCTGCGCAGTAACAATGAAAAAGTACGTGGAA
GAAAACGTGTCCCAGACATCATACACGACCATCAAGTACTTCATGAAGATGCTGAGCAGC
GTCAGCGAGACCTTGATCTTCATCTTCATGGGTGTGTCCACTGTGGGCAAGAATCACGAG
TGGAACTGGGCCTTCATCTGCTTCACCCTGGCCTTCTGCCAAATCTGGAGAGCCATCAGC
GTATTTGCTCTCTTCTATATCAGTAACCAGTTTCGGACTTTCCCCTTCTCCATCAAGGAC
CAGTGCATCATTTTCTACAGTGGTGTTCGAGGAGCTGGAAGTTTTTCACTTGCATTTTTG
CTTCCTCTGTCTCTTTTTCCTAGGAAGAAAATGTTTGTCACTGCTACTCTAGTAGTTATA
TACTTTACTGTATTTATTCAGGGAATCACAGTTGGCCCTCTGGTCAGGTACCTGGATGTT
AAAAAAACCAATAAAAAAGAATCCATCAATGAAGAGCTTCATATTCGTCTGATGGATCAC
TTAAAGGCTGGAATCGAAGATGTGTGTGGGCACTGGAGTCACTACCAAGTGAGAGACAAG
TTTAAGAAGTTTGATCATAGATACTTACGGAAAATCCTCATCAGAAAGAACCTACCCAAA
TCAAGCATTGTTTCTTTGTACAAGAAGCTGGAAATGAAGCAAGCCATCGAGATGGTGGAG
ACTGGGATACTGAGCTCTACAGCTTTCTCCATACCCCATCAGGCCCAGAGGATACAAGGA
ATCAAAAGACTTTCCCCTGAAGATGTGGAGTCCATAAGGGACATTCTGACATCCAACATG
TACCAAGTTCGGCAAAGGACCCTGTCCTACAACAAATACAACCTCAAACCCCAAACAAGT
GAGAAGCAGGCTAAAGAGATTCTGATCCGCCGCCAGAACACCTTAAGGGAGAGCATGAGG
AAAGGTCACAGCCTGCCCTGGGGAAAGCCGGCTGGCACCAAGAATATCCGCTACCTCTCC
TACCCCTACGGGAATCCTCAGTCTGCAGGAAGAGACACAAGGGCTGCTGGGTTCTCAGAT
GATGACAGCAGTGATCCAGGATCCCCATCCATCACGTTCAGCGCATGCTCTCGGATAGGG
TCACTTCAGAAGCAAGAGGCACAAGAAATAATACCAATGAAGAGCCTACACAGAGGAAGG
AAGGCATTCAGCTTTGGTTATCAAAGAAACACAAGCCAAGAAGAGTACTTGGGTGGAGTA
AGGAGGGTGGCCTTAAGACCCAAACCTCTGTTTCATGCAGTGGATGAGGAGGGTGAGTCT
GGAGGGGAGAGTGAGGGCAAGGCCTCTTTGGTTGAGGTTCGGTCGAGGTGGACAGCTGAC
CATGGACACGGCAGGGACCATCACAGGTCCCATAGTCCTTTGCTCCAAAAAAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 798 |
| Molecular Weight
| 89813.4 |
| Theoretical pI
| 8.72 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["95-115", "128-148", "155-175", "197-217", "227-247", "271-291", "305-325", "357-373", "385-405", "451-471"]
|
| Protein Sequence
|
>Sodium/hydrogen exchanger 4
MALQMFVTYSPWNCLLLLVALECSEASSDLNESANSTAQYASNAWFAAASSEPEEGISVF
ELDYDYVQIPYEVTLWILLASLAKIGFHLYHRLPGLMPESCLLILVGALVGGIIFGTDHK
SPPVMDSSIYFLYLLPPIVLEGGYFMPTRPFFENIGSILWWAVLGALINALGIGLSLYLI
CQVKAFGLGDVNLLQNLLFGSLISAVDPVAVLAVFEEARVNEQLYMMIFGEALLNDGITV
VLYNMLIAFTKMHKFEDIETVDILAGCARFIVVGLGGVLFGIVFGFISAFITRFTQNISA
IEPLIVFMFSYLSYLAAETLYLSGILAITACAVTMKKYVEENVSQTSYTTIKYFMKMLSS
VSETLIFIFMGVSTVGKNHEWNWAFICFTLAFCQIWRAISVFALFYISNQFRTFPFSIKD
QCIIFYSGVRGAGSFSLAFLLPLSLFPRKKMFVTATLVVIYFTVFIQGITVGPLVRYLDV
KKTNKKESINEELHIRLMDHLKAGIEDVCGHWSHYQVRDKFKKFDHRYLRKILIRKNLPK
SSIVSLYKKLEMKQAIEMVETGILSSTAFSIPHQAQRIQGIKRLSPEDVESIRDILTSNM
YQVRQRTLSYNKYNLKPQTSEKQAKEILIRRQNTLRESMRKGHSLPWGKPAGTKNIRYLS
YPYGNPQSAGRDTRAAGFSDDDSSDPGSPSITFSACSRIGSLQKQEAQEIIPMKSLHRGR
KAFSFGYQRNTSQEEYLGGVRRVALRPKPLFHAVDEEGESGGESEGKASLVEVRSRWTAD
HGHGRDHHRSHSPLLQKK
|
| External Links |
|---|
| GenBank ID Protein
| 148727259 |
| UniProtKB/Swiss-Prot ID
| Q6AI14 |
| UniProtKB/Swiss-Prot Entry Name
| SL9A4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001011552.3 |
| GeneCard ID
| SLC9A4 |
| GenAtlas ID
| SLC9A4 |
| HGNC ID
| HGNC:11077 |
| References |
|---|
| General References
| Not Available |