Cannabis Compound Database: Showing Protein Sodium-coupled monocarboxylate transporter 2 (CDBP02481)

Identification Biological properties Gene properties Protein properties External links References XML Show 0 compounds

Identification

HMDB Protein ID

CDBP02481

Secondary Accession Numbers

Not Available

Name

Sodium-coupled monocarboxylate transporter 2

Description

Not Available

Synonyms

Electroneutral sodium monocarboxylate cotransporter
Low-affinity sodium-lactate cotransporter
Solute carrier family 5 member 12

Gene Name

SLC5A12

Protein Type

Transporter

Biological Properties

General Function

Involved in transporter activity

Specific Function

Acts as an electroneutral and low-affinity sodium (Na(+))-dependent sodium-coupled solute transporter. Catalyzes the transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, nicotinate, propionate, butyrate and beta-D- hydroxybutyrate. May be responsible for the first step of reabsorption of monocarboxylates from the lumen of the proximal tubule of the kidney and the small intestine. May play also a role in monocarboxylates transport in the retina. Mediates electroneutral uptake of lactate, with a stoichiometry of 2 Na(+) for each lactate

GO Classification

Component
membrane
cell part
Function
transporter activity
Process
establishment of localization
transport
transmembrane transport

Cellular Location

Multi-pass membrane protein
Apical cell membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

11p14.2

SNPs

SLC5A12

Gene Sequence

>1857 bp
ATGGAGGTGAAGAACTTTGCAGTTTGGGATTATGTTGTATTTGCAGCCCTCTTTTTCATT
TCCTCTGGAATTGGGGTGTTCTTTGCCATTAAGGAGAGAAAAAAGGCAACTTCCCGAGAG
TTCCTGGTTGGGGGAAGGCAAATGAGCTTTGGCCCTGTCGGCTTGTCTCTGACAGCCAGC
TTCATGTCAGCTGTCACGGTCCTGGGGACCCCTTCTGAAGTCTACCGCTTTGGGGCATCC
TTCCTAGTCTTCTTCATTGCTTACCTATTTGTCATCCTCTTAACATCAGAGCTCTTTCTC
CCTGTGTTCTACAGATCTGGTATCACCAGCACTTATGAGTACTTACAACTACGATTCAAC
AAACCAGTTCGCTATGCTGCCACGGTCATCTACATTGTACAGACGATTCTCTACACAGGA
GTGGTGGTGTATGCTCCTGCCCTGGCACTCAATCAAGTGACTGGGTTTGATCTCTGGGGC
TCTGTGTTTGCAACAGGAATTGTTTGCACATTCTACTGTACCCTGGGAGGATTAAAAGCA
GTGGTGTGGACAGATGCATTTCAGATGGTTGTCATGATTGTGGGCTTCTTAACGGTTCTC
ATTCAAGGATCAACTCATGCTGGGGGATTCCACAATGTATTAGAGCAATCAACAAATGGA
TCTCGACTACATATATTTGACTTTGATGTAGATCCTCTCAGGCGACACACTTTTTGGACT
ATCACAGTGGGAGGAACTTTTACTTGGCTCGGAATCTATGGGGTCAATCAATCAACTATT
CAGCGATGCATCTCTTGCAAAACAGAAAAGCATGCTAAGCTTGCCTTGTATTTTAACTTG
CTGGGTCTCTGGATCATTCTGGTGTGTGCTGTCTTCTCTGGCTTAATCATGTACTCTCAC
TTTAAAGACTGTGACCCTTGGACTTCTGGCATCATCTCAGCACCAGACCAGCTGATGCCG
TACTTTGTCATGGAGATATTTGCCACAATGCCAGGACTGCCAGGACTTTTTGTGGCTTGT
GCCTTCAGTGGAACTCTGAGCACCGTGGCTTCCAGCATCAATGCCTTGGCAACAGTGACC
TTTGAGGATTTTGTCAAGAGCTGTTTTCCTCATCTCTCCGACAAGCTGAGCACCTGGATC
AGTAAAGGCTTATGTCTCTTATTTGGCGTGATGTGTACCTCTATGGCTGTGGCTGCATCT
GTCATGGGAGGTGTTGTGCAGGCTTCCCTCAGCATTCACGGCATGTGTGGAGGACCAATG
CTGGGCTTATTCTCCCTGGGAATCGTGTTCCCTTTTGTGAATTGGAAGGGTGCACTAGGA
GGTCTTCTTACTGGAATCACCTTGTCATTTTGGGTGGCCATTGGGGCCTTCATTTACCCT
GCACCAGCCTCTAAGACATGGCCTTTGCCTCTGTCAACAGACCAATGTATCAAATCAAAT
GTGACAGCAACAGGGCCTCCAGTACTATCCAGCAGACCTGGAATAGCTGATACCTGGTAC
TCGATCTCCTACCTTTACTACAGTGCAGTGGGCTGCTTAGGATGCATTGTTGCTGGAGTA
ATCATCAGCCTCATAACAGGTCGCCAAAGAGGTGAGGATATTCAACCACTGTTAATTAGA
CCAGTTTGTAATTTATTTTGCTTTTGGTCTAAGAAGTACAAAACACTATGCTGGTGTGGA
GTTCAGCATGACAGTGGGACAGAGCAGGAAAACCTTGAGAATGGCAGTGCCCGGAAACAG
GGGGCTGAATCTGTCTTACAGAACGGACTCAGAAGAGAAAGCCTGGTACATGTTCCAGGC
TATGATCCTAAGGACAAAAGCTACAACAATATGGCATTTGAGACTACCCATTTCTAA

Protein Properties

Number of Residues

618

Molecular Weight

67646.4

Theoretical pI

8.16

Pfam Domain Function

SSF (PF00474 )

Signals

["None"]

Transmembrane Regions

["10-30", "48-68", "83-103", "129-149", "158-178", "181-201", "236-256", "276-296", "322-342", "386-406", "412-432", "438-458", "505-525"]

Protein Sequence

>Sodium-coupled monocarboxylate transporter 2
MEVKNFAVWDYVVFAALFFISSGIGVFFAIKERKKATSREFLVGGRQMSFGPVGLSLTAS
FMSAVTVLGTPSEVYRFGASFLVFFIAYLFVILLTSELFLPVFYRSGITSTYEYLQLRFN
KPVRYAATVIYIVQTILYTGVVVYAPALALNQVTGFDLWGSVFATGIVCTFYCTLGGLKA
VVWTDAFQMVVMIVGFLTVLIQGSTHAGGFHNVLEQSTNGSRLHIFDFDVDPLRRHTFWT
ITVGGTFTWLGIYGVNQSTIQRCISCKTEKHAKLALYFNLLGLWIILVCAVFSGLIMYSH
FKDCDPWTSGIISAPDQLMPYFVMEIFATMPGLPGLFVACAFSGTLSTVASSINALATVT
FEDFVKSCFPHLSDKLSTWISKGLCLLFGVMCTSMAVAASVMGGVVQASLSIHGMCGGPM
LGLFSLGIVFPFVNWKGALGGLLTGITLSFWVAIGAFIYPAPASKTWPLPLSTDQCIKSN
VTATGPPVLSSRPGIADTWYSISYLYYSAVGCLGCIVAGVIISLITGRQRGEDIQPLLIR
PVCNLFCFWSKKYKTLCWCGVQHDSGTEQENLENGSARKQGAESVLQNGLRRESLVHVPG
YDPKDKSYNNMAFETTHF

External Links

GenBank ID Protein

157671931

UniProtKB/Swiss-Prot ID

Q1EHB4

UniProtKB/Swiss-Prot Entry Name

SC5AC_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_178498.3

GeneCard ID