| Identification |
|---|
| HMDB Protein ID
| CDBP02476 |
| Secondary Accession Numbers
| Not Available |
| Name
| Uridine phosphorylase 1 |
| Description
| Not Available |
| Synonyms
|
- UPase 1
- UrdPase 1
|
| Gene Name
| UPP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring pentosyl groups |
| Specific Function
| Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.
|
| GO Classification
|
| Biological Process |
| pyrimidine nucleobase metabolic process |
| pyrimidine nucleoside catabolic process |
| UMP salvage |
| nucleotide catabolic process |
| uridine metabolic process |
| pyrimidine nucleoside salvage |
| Cellular Component |
| cytosol |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| uridine phosphorylase activity |
| catalytic activity |
| transferase activity |
| transferase activity, transferring pentosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| uridine phosphorylase activity |
| Process |
| nitrogen compound metabolic process |
| cellular nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleotide metabolic process |
| nucleotide catabolic process |
| nucleoside metabolic process |
| metabolic process |
|
| Cellular Location
|
Not Available
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | UMP biosynthesis via salvage pathway | Not Available | Not Available | | Drug metabolism - other enzymes | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 7 |
| Locus
| 7p12.3 |
| SNPs
| UPP1 |
| Gene Sequence
|
>933 bp
ATGGCGGCCACGGGAGCCAATGCAGAGAAAGCTGAAAGTCACAATGATTGCCCCGTCAGA
CTTTTAAATCCAAACATAGCAAAAATGAAAGAAGATATTCTCTATCATTTCAATCTCACC
ACTAGCAGACACAATTTCCCAGCCTTGTTTGGAGATGTGAAGTTTGTGTGTGTTGGTGGA
AGCCCCTCCCGGATGAAAGCCTTCATCAGGTGCGTTGGTGCAGAGCTGGGCCTTGACTGC
CCAGGTAGAGACTATCCCAACATCTGTGCGGGAACTGACCGCTATGCCATGTATAAAGTA
GGACCGGTGCTGTCTGTCAGTCATGGTATGGGCATTCCTTCTATCTCAATCATGTTGCAT
GAGCTCATAAAGCTGCTGTACTATGCCCGGTGCTCCAACGTCACTATCATCCGCATTGGC
ACTTCTGGTGGGATAGGTCTGGAGCCCGGCACTGTGGTCATAACAGAGCAGGCAGTGGAT
ACCTGCTTCAAGGCAGAGTTTGAGCAGATTGTCCTGGGGAAGCGGGTCATCCGGAAAACG
GACCTTAACAAGAAGCTGGTGCAGGAGCTGTTGCTGTGTTCTGCAGAGCTGAGCGAGTTC
ACCACAGTGGTGGGGAACACCATGTGCACCTTGGACTTCTATGAAGGGCAAGGCCGTCTG
GATGGGGCTCTCTGCTCCTACACGGAGAAGGACAAGCAGGCGTATCTGGAGGCAGCCTAT
GCAGCCGGCGTCCGCAATATCGAGATGGAGTCCTCGGTGTTTGCCGCCATGTGCAGCGCC
TGCGGCCTCCAAGCGGCCGTGGTGTGTGTCACCCTCCTGAACCGCCTGGAAGGGGACCAG
ATCAGCAGCCCTCGCAATGTGCTCAGCGAGTACCAGCAGAGGCCGCAGCGGCTGGTGAGC
TACTTCATCAAGAAGAAACTGAGCAAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 310 |
| Molecular Weight
| 33934.005 |
| Theoretical pI
| 7.886 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Uridine phosphorylase 1
MAATGANAEKAESHNDCPVRLLNPNIAKMKEDILYHFNLTTSRHNFPALFGDVKFVCVGG
SPSRMKAFIRCVGAELGLDCPGRDYPNICAGTDRYAMYKVGPVLSVSHGMGIPSISIMLH
ELIKLLYYARCSNVTIIRIGTSGGIGLEPGTVVITEQAVDTCFKAEFEQIVLGKRVIRKT
DLNKKLVQELLLCSAELSEFTTVVGNTMCTLDFYEGQGRLDGALCSYTEKDKQAYLEAAY
AAGVRNIEMESSVFAAMCSACGLQAAVVCVTLLNRLEGDQISSPRNVLSEYQQRPQRLVS
YFIKKKLSKA
|
| External Links |
|---|
| GenBank ID Protein
| 1050525 |
| UniProtKB/Swiss-Prot ID
| Q16831 |
| UniProtKB/Swiss-Prot Entry Name
| UPP1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| X90858 |
| GeneCard ID
| UPP1 |
| GenAtlas ID
| UPP1 |
| HGNC ID
| HGNC:12576 |
| References |
|---|
| General References
| Not Available |