| Identification |
|---|
| HMDB Protein ID
| CDBP02471 |
| Secondary Accession Numbers
| Not Available |
| Name
| Exostosin-like 2 |
| Description
| Not Available |
| Synonyms
|
- Alpha-1,4-N-acetylhexosaminyltransferase EXTL2
- Alpha-GalNAcT EXTL2
- EXT-related protein 2
- Glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase
- Processed exostosin-like 2
|
| Gene Name
| EXTL2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in transferase activity, transferring hexosyl groups |
| Specific Function
| Glycosyltransferase required for the biosynthesis of heparan-sulfate and responsible for the alternating addition of beta-1-4-linked glucuronic acid (GlcA) and alpha-1-4-linked N-acetylglucosamine (GlcNAc) units to nascent heparan sulfate chains.
|
| GO Classification
|
| Biological Process |
| heparan sulfate proteoglycan biosynthetic process |
| UDP-N-acetylgalactosamine metabolic process |
| N-acetylglucosamine metabolic process |
| Cellular Component |
| endoplasmic reticulum |
| intrinsic to endoplasmic reticulum membrane |
| extracellular region |
| integral to membrane |
| Component |
| intrinsic to endoplasmic reticulum membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| intrinsic to organelle membrane |
| Function |
| catalytic activity |
| transferase activity |
| transferase activity, transferring hexosyl groups |
| transferase activity, transferring glycosyl groups |
| Molecular Function |
| metal ion binding |
| alpha-1,4-N-acetylgalactosaminyltransferase activity |
| glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity |
|
| Cellular Location
|
- Processed exostosin-like 2:Secreted
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | heparan sulfate biosynthesis | Not Available | Not Available | | Glycosaminoglycan biosynthesis - heparan sulfate / heparin | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p21 |
| SNPs
| EXTL2 |
| Gene Sequence
|
>993 bp
ATGAGGTGTTGCCACATCTGCAAACTTCCTGGGAGAGTAATGGGGATTCGAGTGCTTCGA
TTATCTTTGGTGGTCATCCTCGTATTATTACTGGTAGCTGGTGCTTTGACTGCCTTACTT
CCCAGTGTTAAAGAAGACAAGATGCTCATGTTGCGTAGGGAAATAAAATCCCAGGGCAAG
TCCACCATGGACTCCTTTACTCTCATAATGCAGACGTACAACAGAACAGATCTCTTATTG
AAACTTTTAAATCATTATCAGGCTGTACCAAATCTGCACAAAGTGATTGTGGTATGGAAC
AATATTGGAGAGAAGGCACCAGATGAATTATGGAATTCTCTAGGGCCCCACCCTATCCCT
GTGATCTTCAAACAACAGACAGCAAACAGGATGAGAAATCGACTCCAGGTCTTTCCTGAA
CTGGAAACCAATGCAGTGTTGATGGTAGATGATGACACACTCATCAGCACCCCAGACCTT
GTTTTTGCTTTCTCAGTTTGGCAGCAATTTCCTGATCAAATTGTAGGATTTGTTCCTAGA
AAGCACGTCTCTACTTCATCAGGTATCTACAGTTATGGAAGTTTTGAAATGCAAGCACCA
GGGTCTGGAAATGGTGACCAGTACTCTATGGTGCTGATTGGAGCCTCATTCTTCAATAGC
AAATATCTTGAATTATTTCAGAGGCAACCTGCAGCTGTCCATGCTTTGATAGATGATACT
CAAAACTGTGATGATATTGCCATGAATTTTATCATTGCCAAGCATATTGGCAAGACTTCA
GGGATATTTGTGAAGCCTGTAAACATGGACAATTTGGAAAAAGAAACCAACAGTGGCTAT
TCTGGAATGTGGCATCGAGCTGAGCACGCTCTGCAGAGGTCTTATTGTATAAATAAGCTT
GTTAATATCTATGATAGCATGCCCTTAAGATACTCCAACATTATGATTTCCCAGTTTGGT
TTTCCATATGCCAACTACAAAAGAAAAATATAA
|
| Protein Properties |
|---|
| Number of Residues
| 330 |
| Molecular Weight
| 37465.365 |
| Theoretical pI
| 8.947 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Exostosin-like 2
MRCCHICKLPGRVMGIRVLRLSLVVILVLLLVAGALTALLPSVKEDKMLMLRREIKSQGK
STMDSFTLIMQTYNRTDLLLKLLNHYQAVPNLHKVIVVWNNIGEKAPDELWNSLGPHPIP
VIFKQQTANRMRNRLQVFPELETNAVLMVDDDTLISTPDLVFAFSVWQQFPDQIVGFVPR
KHVSTSSGIYSYGSFEMQAPGSGNGDQYSMVLIGASFFNSKYLELFQRQPAAVHALIDDT
QNCDDIAMNFIIAKHIGKTSGIFVKPVNMDNLEKETNSGYSGMWHRAEHALQRSYCINKL
VNIYDSMPLRYSNIMISQFGFPYANYKRKI
|
| External Links |
|---|
| GenBank ID Protein
| 2895062 |
| UniProtKB/Swiss-Prot ID
| Q9UBQ6 |
| UniProtKB/Swiss-Prot Entry Name
| EXTL2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF000416 |
| GeneCard ID
| EXTL2 |
| GenAtlas ID
| EXTL2 |
| HGNC ID
| HGNC:3516 |
| References |
|---|
| General References
| Not Available |