Cannabis Compound Database: Showing Protein Histone-lysine N-methyltransferase SETDB2 (CDBP02460)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP02460

Secondary Accession Numbers

Not Available

Name

Histone-lysine N-methyltransferase SETDB2

Description

Not Available

Synonyms

Chronic lymphocytic leukemia deletion region gene 8 protein
Lysine N-methyltransferase 1F
SET domain bifurcated 2

Gene Name

SETDB2

Protein Type

Enzyme

Biological Properties

General Function

Involved in DNA binding

Specific Function

Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.

GO Classification

Biological Process
negative regulation of transcription, DNA-dependent
heart looping
left/right axis specification
mitosis
cell division
chromosome segregation
Cellular Component
chromosome
nucleus
Component
organelle
membrane-bounded organelle
intracellular membrane-bounded organelle
nucleus
Function
zinc ion binding
transferase activity
protein methyltransferase activity
protein-lysine n-methyltransferase activity
histone-lysine n-methyltransferase activity
nucleic acid binding
dna binding
transferase activity, transferring one-carbon groups
methyltransferase activity
ion binding
cation binding
metal ion binding
binding
catalytic activity
transition metal ion binding
Molecular Function
histone methyltransferase activity (H3-K9 specific)
metal ion binding
zinc ion binding
DNA binding
Process
chromosome organization
chromatin organization
chromatin modification
cellular process
cellular component organization at cellular level
organelle organization

Cellular Location

Nucleus
Chromosome (Probable)

Pathways

Not Available

Gene Properties

Chromosome Location

Locus

13q14

SNPs

SETDB2

Gene Sequence

>2160 bp
ATGGGAGAAAAAAATGGCGATGCAAAAACTTTCTGGATGGAGCTAGAAGATGATGGAAAA
GTGGACTTCATTTTTGAACAAGTACAAAATGTGCTGCAGTCACTGAAACAAAAGATCAAA
GATGGGTCTGCCACCAATAAAGAATACATCCAAGCAATGATTCTAGTGAATGAAGCAACT
ATAATTAACAGTTCAACATCAATAAAGGGAGCATCACAGAAAGAAGTGAATGCCCAAAGC
AGTGATCCTATGCCTGTGACTCAGAAGGAACAGGAAAACAAATCCAATGCATTTCCCTCT
ACATCATGTGAAAACTCCTTTCCAGAAGACTGTACATTTCTAACAACAGGAAATAAGGAA
ATTCTCTCTCTTGAAGATAAAGTTGTAGACTTTAGAGAAAAAGACTCATCTTCGAATTTA
TCTTACCAAAGTCATGACTGCTCTGGTGCTTGTCTGATGAAAATGCCACTGAACTTGAAG
GGAGAAAACCCTCTGCAGCTGCCAATCAAATGTCACTTCCAAAGACGACATGCAAAGACA
AACTCTCATTCTTCAGCACTCCACGTGAGTTATAAAACCCCTTGTGGAAGGAGTCTACGA
AACGTGGAGGAAGTTTTTCGTTACCTGCTTGAGACAGAGTGTAACTTTTTATTTACAGAT
AACTTTTCTTTCAATACCTATGTTCAGTTGGCTCGGAATTACCCAAAGCAAAAAGAAGTT
GTTTCTGATGTGGATATTAGCAATGGAGTGGAATCAGTGCCCATTTCTTTCTGTAATGAA
ATTGACAGTAGAAAGCTCCCACAGTTTAAGTACAGAAAGACTGTGTGGCCTCGAGCATAT
AATCTAACCAACTTTTCCAGCATGTTTACTGATTCCTGTGACTGCTCTGAGGGCTGCATA
GACATAACAAAATGTGCATGTCTTCAACTGACAGCAAGGAATGCCAAAACTTCCCCCTTG
TCAAGTGACAAAATAACCACTGGATATAAATATAAAAGACTACAGAGACAGATTCCTACT
GGCATTTATGAATGCAGCCTTTTGTGCAAATGTAATCGACAATTGTGTCAAAACCGAGTT
GTCCAACATGGTCCTCAAGTGAGGTTACAGGTGTTCAAAACTGAGCAGAAGGGATGGGGT
GTACGCTGTCTAGATGACATTGACAGAGGGACATTTGTTTGCATTTATTCAGGAAGATTA
CTAAGCAGAGCTAACACTGAAAAATCTTATGGTATTGATGAAAACGGGAGAGATGAGAAT
ACTATGAAAAATATATTTTCAAAAAAGAGGAAATTAGAAGTTGCATGTTCAGATTGTGAA
GTTGAAGTTCTCCCATTAGGATTGGAAACACATCCTAGAACTGCTAAAACTGAGAAATGT
CCACCAAAGTTCAGTAATAATCCCAAGGAGCTTACTATGGAAACGAAATATGATAATATT
TCAAGAATTCAATATCATTCAGTTATTAGAGATCCTGAATCCAAGACAGCCATTTTTCAA
CACAATGGGAAAAAAATGGAATTTGTTTCCTCGGAGTCTGTCACTCCAGAAGATAATGAT
GGATTTAAACCACCCCGAGAGCATCTGAACTCTAAAACCAAGGGAGCACAAAAGGACTCA
AGTTCAAACCATGTTGATGAGTTTGAAGATAATCTGCTGATTGAATCAGATGTGATAGAT
ATAACTAAATATAGAGAAGAAACTCCACCAAGGAGCAGATGTAACCAGGCGACCACATTG
GATAATCAGAATATTAAAAAGGCAATTGAGGTTCAAATTCAGAAACCCCAAGAGGGACGA
TCTACAGCATGTCAAAGACAGCAGGTATTTTGTGATGAAGAGTTGCTAAGTGAAACCAAG
AATACTTCATCTGATTCTCTAACAAAGTTCAATAAAGGGAATGTGTTTTTATTGGATGCC
ACAAAAGAAGGAAATGTCGGCCGCTTCCTTAATCATAGTTGTTGCCCAAATCTCTTGGTA
CAGAATGTTTTTGTAGAAACACACAACAGGAATTTTCCATTGGTGGCATTCTTCACCAAC
AGGTATGTGAAAGCAAGAACAGAGCTAACATGGGATTATGGCTATGAAGCTGGGACTGTG
CCTGAGAAGGAAATCTTCTGCCAATGTGGGGTTAATAAATGTAGAAAAAAAATATTATAA

Protein Properties

Number of Residues

719

Molecular Weight

80706.48

Theoretical pI

7.504

Pfam Domain Function

SET (PF00856 )
MBD (PF01429 )
Pre-SET (PF05033 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Histone-lysine N-methyltransferase SETDB2
MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSATNKEYIQAMILVNEAT
IINSSTSIKGASQKEVNAQSSDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFLTTENKE
ILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCHFQRRHAKT
NSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQLARNYPKQKEV
VSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSMFTDSCDCSEGCI
DITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECSLLCKCNRQLCQNRV
VQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRANTEKSYGIDENGRDEN
TMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPPKFSNNPKELTVETKYDNI
SRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDNDGFKPPREHLNSKTKGAQKDS
SSNHVDEFEDNLLIESDVIDITKYREETPPRSRCNQATTLDNQNIKKAIEVQIQKPQEGR
STACQRQQVFCDEELLSETKNTSSDSLTKFNKGNVFLLDATKEGNVGRFLNHSCCPNLLV
QNVFVETHNRNFPLVAFFTNRYVKARTELTWDYGYEAGTVPEKEIFCQCGVNKCRKKIL

External Links

GenBank ID Protein

13699244

UniProtKB/Swiss-Prot ID

Q96T68

UniProtKB/Swiss-Prot Entry Name

SETB2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF334407

GeneCard ID