Cannabis Compound Database: Showing Protein Electrogenic sodium bicarbonate cotransporter 4 (CDBP02457)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02457

Secondary Accession Numbers

Not Available

Name

Electrogenic sodium bicarbonate cotransporter 4

Description

Not Available

Synonyms

NBCe2
Solute carrier family 4 member 5

Gene Name

SLC4A5

Protein Type

Transporter

Biological Properties

General Function

Involved in anion transport

Specific Function

Mediates sodium- and bicarbonate-dependent electrogenic sodium bicarbonate cotransport, with a Na(+):HCO3(-) stoichiometry of 2:1. May have a housekeeping function in regulating the pH of tissues in which it is expressed. May play a role in mediating Na(+):HCO3(-) cotransport in hepatocytes and intrahepatic cholangiocytes. Also may be important in protecting the renal paranchyma from alterations in urine pH

GO Classification

Component
membrane
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
ion transmembrane transporter activity
anion:anion antiporter activity
transporter activity
anion transmembrane transporter activity
inorganic anion exchanger activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
Process
establishment of localization
transport
anion transport
ion transport

Cellular Location

Multi-pass membrane protein
Apical cell membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:2

Locus

2p13

SNPs

SLC4A5

Gene Sequence

>3414 bp
ATGAAGGTGAAGGAGGAGAAGGCTGGGGTAGGAAAGCTGGACCACACTAACCACAGGAGG
AGATTTCCGGATCAGAAAGAATGCCCTCCTATCCACATTGGGCTTCCAGTACCCACTTAC
CCTCAAAGAAAAACTGACCAGAAGGGACATCTTTCAGGCCTGCAAAAAGTCCACTGGGGC
CTGCGGCCAGACCAGCCACAGCAGGAACTGACTGGCCCAGGGAGTGGGGCAAGCAGCCAG
GACAGCAGCATGGATCTTATCAGCAGGACTCGGTCCCCAGCTGCTGAGCAGCTCCAGGAC
ATCCTGGGGGAGGAAGATGAGGCTCCCAACCCCACCCTCTTTACAGAGATGGATACTCTG
CAGCATGACGGAGACCAGATGGAGTGGAAGGAGTCAGCCAGGTGGATAAAGTTTGAAGAA
AAGGTAGAGGAAGGCGGCGAACGCTGGAGCAAGCCCCACGTGTCCACACTATCCCTGCAC
AGCCTCTTCGAGCTCCGTACCTGCCTGCAGACGGGGACGGTGCTGCTGGATTTGGACAGT
GGCTCCTTACCACAGATCATAGATGATGTCATTGAGAAGCAGATTGAGGATGGTCTCCTG
CGGCCAGAGCTCCGGGAGAGGGTCAGTTACGTCCTCCTGAGGAGGCACCGCCACCAAACC
AAGAAGCCCATCCACCGCTCCTTAGCTGACATTGGGAAGTCAGTCTCCACCACAAATCGC
AGTCCTGCCCGGAGCCCTGGTGCTGGCCCGAGTCTACACCACTCCACGGAAGACCTGCGG
ATGCGGCAGAGTGCAAATTACGGACGTCTGTGTCATGCCCAGAGCAGAAGCATGAATGAC
ATTTCTCTCACCCCAAACACAGACCAGCGGAAAAACAAATTCATGAAGAAGATCCCCAAG
GACTCAGAAGCGTCCAACGTGCTCGTGGGCGAGGTGGACTTCCTAGACCAGCCATTCATC
GCGTTCGTGCGCCTCATCCAGTCGGCCATGCTGGGAGGAGTGACCGAGGTGCCTGTCCCC
ACCAGATTTCTGTTTATACTACTGGGACCTTCTGGGAGAGCAAAATCCTACAATGAAATT
GGCCGTGCCATTGCAACCCTCATGGTAGATGATCTCTTCAGTGACGTGGCCTACAAAGCC
CGCAATCGGGAAGATCTGATCGCAGGAATTGATGAATTTCTGGATGAGGTCATCGTCCTT
CCTCCTGGAGAATGGGACCCAAATATCCGGATTGAGCCCCCCAAGAAGGTGCCCTCTGCT
GACAAGAGGAAATCTGTGTTCTCCCTAGCAGAGCTGGGCCAGATGAATGGCTCTGTGGGA
GGAGGCGGCGGAGCTCCTGGAGGAGGCAATGGAGGTGGTGGTGGTGGTGGCAGTGGCGGC
GGGGCTGGCAGTGGCGGGGCCGGCGGAACAAGCAGCGGGGATGATGGAGAGATGCCAGCC
ATGCATGAAATCGGGGAGGAACTTATCTGGACAGGAAGGTTCTTCGGTGGCCTGTGTCTG
GATATCAAGAGGAAGTTGCCCTGGTTCCCAAGTGACTTCTATGATGGCTTCCACATTCAG
TCCATCTCTGCCATCCTATTCATCTACCTCGGCTGTATCACCAACGCGATCACCTTTGGT
GGGCTTCTGGGGGATGCCACCGACAATTATCAGGGAGTGATGGAGAGCTTCCTGGGCACT
GCCATGGCTGGCTCCTTGTTCTGCCTCTTCTCGGGACAGCCTCTCATCATTCTCAGCAGC
ACGGGGCCCATCCTCATCTTTGAGAAGCTCCTCTTCGACTTCAGCAAAGGCAATGGCCTG
GACTACATGGAGTTCCGCCTCTGGATTGGCCTACACTCAGCTGTCCAGTGCCTTATCCTA
GTGGCCACAGATGCCAGCTTTATCATCAAATATATCACCCGCTTCACCGAGGAGGGCTTC
TCCACCCTTATCAGCTTCATCTTCATCTACGATGCCATCAAGAAGATGATCGGTGCCTTC
AAGTACTACCCTATCAATATGGACTTCAAGCCAAACTTCATCACTACCTACAAGTGCGAG
TGTGTCGCCCCTGACACAGTGAATACAACCGTGTTCAATGCTTCAGCCCCATTGGCACCA
GACACCAACGCTTCTCTGTACAACCTCCTTAACCTCACAGCGTTGGACTGGTCCCTGCTG
AGCAAGAAGGAGTGTCTGAGCTACGGCGGGCGCCTGCTTGGGAATTCCTGCAAGTTTATC
CCAGACCTGGCGCTCATGTCCTTCATCCTTTTCTTTGGGACATACTCCATGACCCTGACC
CTGAAGAAGTTCAAATTCAGCCGCTATTTTCCTACCAAGGTCCGGGCCCTGGTGGCTGAC
TTTTCCATTGTTTTCTCCATCCTGATGTTCTGTGGAATCGATGCCTGTTTTGGCCTAGAA
ACTCCCAAGCTGCATGTGCCCAGTGTCATCAAGCCAACGCGGCCTGACCGAGGCTGGTTC
GTGGCCCCCTTTGGGAAGAACCCGTGGTGGGTATACCCAGCAAGCATCCTGCCCGCCCTG
CTGGTGACCATCCTGATCTTCATGGACCAGCAGATCACTGCCGTCATTGTCAACCGGAAG
GAGAACAAACTGAAGAAGGCTGCCGGCTACCATCTGGACCTGTTCTGGGTGGGCATCCTC
ATGGCTTTGTGCTCCTTTATGGGGCTCCCCTGGTACGTGGCTGCCACGGTCATCTCCATC
GCCCACATCGACAGCCTCAAGATGGAGACAGAGACCAGTGCCCCTGGGGAGCAGCCCCAG
TTTCTGGGAGTCAGGGAACAGAGAGTAACCGGCATCATCGTCTTCATCCTGACGGGAATC
TCTGTCTTCCTGGCTCCCATCCTAAAGTGTATCCCCCTGCCGGTGCTGTACGGAGTCTTC
CTCTACATGGGCGTGGCCTCCCTGAATGGCATCCAGATGGGGACCGGAGGGTCAGAATTC
AAAATCCAGAAGAAGCTGACTCCATTCTGGGAACGCTGCAAGCTCTTCCTGATGCCAGCC
AAGCACCAGCCGGACCATGCCTTCCTGCGGCACGTGCCGCTGCGCCGGATCCACCTCTTC
ACCCTGGTGCAGATCCTCTGCCTGGCGGTGCTCTGGATCCTCAAATCCACGGTGGCTGCC
ATCATCTTCCCGGTCATGATCCTGGGCCTCATCATCGTTCGAAGGCTTCTGGATTTCATC
TTTTCCCAGCACGACCTGGCCTGGATTGACAACATCCTCCCAGAGAAGGAAAAAAAGGAG
ACAGACAAGAAGAGGAAGAGAAAAAAAGGGGCCCACGAGGACTGTGATGAGGAGCCCCAG
TTCCCTCCTCCCTCGGTTATAAAGATTCCCATGGAAAGTGTCCAATCAGATCCCCAAAAC
GGTATCCACTGCATTGCCAGAAAAAGATCTTCCAGTTGGAGTTACTCACTCTGA

Protein Properties

Number of Residues

1137

Molecular Weight

126254.0

Theoretical pI

7.98

Pfam Domain Function

Band_3_cyto; (PF07565 )
HCO3_cotransp (PF00955 )

Signals

["None"]

Transmembrane Regions

["524-544", "567-587", "609-629", "640-660", "739-759", "777-797", "828-848", "874-894", "931-951", "953-973", "1012-1032", "1033-1053"]

Protein Sequence

>Electrogenic sodium bicarbonate cotransporter 4
MKVKEEKAGVGKLDHTNHRRRFPDQKECPPIHIGLPVPTYPQRKTDQKGHLSGLQKVHWG
LRPDQPQQELTGPGSGASSQDSSMDLISRTRSPAAEQLQDILGEEDEAPNPTLFTEMDTL
QHDGDQMEWKESARWIKFEEKVEEGGERWSKPHVSTLSLHSLFELRTCLQTGTVLLDLDS
GSLPQIIDDVIEKQIEDGLLRPELRERVSYVLLRRHRHQTKKPIHRSLADIGKSVSTTNR
SPARSPGAGPSLHHSTEDLRMRQSANYGRLCHAQSRSMNDISLTPNTDQRKNKFMKKIPK
DSEASNVLVGEVDFLDQPFIAFVRLIQSAMLGGVTEVPVPTRFLFILLGPSGRAKSYNEI
GRAIATLMVDDLFSDVAYKARNREDLIAGIDEFLDEVIVLPPGEWDPNIRIEPPKKVPSA
DKRKSVFSLAELGQMNGSVGGGGGAPGGGNGGGGGGGSGGGAGSGGAGGTSSGDDGEMPA
MHEIGEELIWTGRFFGGLCLDIKRKLPWFPSDFYDGFHIQSISAILFIYLGCITNAITFG
GLLGDATDNYQGVMESFLGTAMAGSLFCLFSGQPLIILSSTGPILIFEKLLFDFSKGNGL
DYMEFRLWIGLHSAVQCLILVATDASFIIKYITRFTEEGFSTLISFIFIYDAIKKMIGAF
KYYPINMDFKPNFITTYKCECVAPDTVNTTVFNASAPLAPDTNASLYNLLNLTALDWSLL
SKKECLSYGGRLLGNSCKFIPDLALMSFILFFGTYSMTLTLKKFKFSRYFPTKVRALVAD
FSIVFSILMFCGIDACFGLETPKLHVPSVIKPTRPDRGWFVAPFGKNPWWVYPASILPAL
LVTILIFMDQQITAVIVNRKENKLKKAAGYHLDLFWVGILMALCSFMGLPWYVAATVISI
AHIDSLKMETETSAPGEQPQFLGVREQRVTGIIVFILTGISVFLAPILKCIPLPVLYGVF
LYMGVASLNGIQMGTGGSEFKIQKKLTPFWERCKLFLMPAKHQPDHAFLRHVPLRRIHLF
TLVQILCLAVLWILKSTVAAIIFPVMILGLIIVRRLLDFIFSQHDLAWIDNILPEKEKKE
TDKKRKRKKGAHEDCDEEPQFPPPSVIKIPMESVQSDPQNGIHCIARKRSSSWSYSL

External Links

GenBank ID Protein

125987596

UniProtKB/Swiss-Prot ID

Q9BY07

UniProtKB/Swiss-Prot Entry Name

S4A5_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_021196.3

GeneCard ID