Showing Protein Solute carrier organic anion transporter family member 3A1 (CDBP02453)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 compounds
Identification
HMDB Protein ID CDBP02453
Secondary Accession Numbers Not Available
Name Solute carrier organic anion transporter family member 3A1
Description Not Available
Synonyms
  1. OATP-D
  2. OATP-RP3
  3. OATP3A1
  4. OATPRP3
  5. Organic anion transporter polypeptide-related protein 3
  6. Organic anion-transporting polypeptide D
  7. PGE1 transporter
  8. Sodium-independent organic anion transporter D
  9. Solute carrier family 21 member 11
Gene Name SLCO3A1
Protein Type Transporter
Biological Properties
General Function Involved in transporter activity
Specific Function Mediates the Na(+)-independent transport of organic anions such as estrone-3-sulfate (PubMed:10873595). Mediates transport of prostaglandins (PG) E1 and E2, thyroxine (T4), deltorphin II, BQ-123 and vasopressin, but not DPDPE (a derivative of enkephalin lacking an N-terminal tyrosine residue), estrone-3- sulfate, taurocholate, digoxin nor DHEAS (PubMed:16971491)
GO Classification
Component
membrane
cell part
Function
transporter activity
Process
establishment of localization
transport
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q26
SNPs SLCO3A1
Gene Sequence 
>2133 bp
ATGCAGGGGAAGAAGCCGGGCGGTTCGTCGGGCGGCGGCCGGAGCGGCGAGCTGCAGGGG
GACGAGGCGCAGAGGAACAAGAAAAAGAAAAAGAAGGTGTCCTGCTTTTCCAACATCAAG
ATCTTCCTGGTGTCCGAGTGCGCCCTGATGCTGGCGCAGGGCACGGTGGGCGCCTACCTG
GTGAGCGTCCTGACCACCCTGGAGCGTAGGTTCAACCTGCAGAGCGCTGACGTGGGTGTG
ATCGCTAGCAGCTTCGAGATCGGGAACCTGGCGCTCATCCTCTTCGTGAGCTACTTCGGG
GCACGCGGGCACCGGCCGCGCCTGATCGGCTGCGGCGGCATCGTCATGGCGCTGGGCGCG
CTGCTGTCGGCGCTGCCCGAGTTCCTGACCCACCAGTACAAGTACGAGGCGGGCGAGATC
CGCTGGGGCGCCGAGGGCCGCGACGTCTGCGCAGCCAACGGCTCGGGCGGCGACGAGGGG
CCCGACCCCGACCTCATCTGCCGCAACCGGACGGCTACCAACATGATGTACTTGCTGCTC
ATTGGGGCCCAGGTGCTCCTGGGCATCGGTGCTACCCCTGTGCAGCCCCTGGGCGTCTCC
TACTACGACGACCACGTGCGGAGGAAGGACTCCTCGCTCTATATAGGAATCCTGTTCACG
ATGCTGGTATTTGGACCAGCCTGCGGGTTTATCCTGGGCTCTTTCTGTACCAAAATCTAC
GTGGATGCGGTCTTCATTGACACAAGTAACCTGGACATCACTCCGGACGACCCCCGCTGG
ATCGGAGCCTGGTGGGGTGGCTTTCTGCTCTGCGGTGCCTTACTCTTCTTCTCTTCCCTC
TTGATGTTTGGGTTTCCACAGTCCCTGCCCCCGCACTCAGACCCCGCCATGGAAAGCGAG
CAGGCCATGCTCTCCGAAAGAGAATACGAGAGACCCAAGCCCAGCAACGGGGTCCTGAGG
CACCCCCTGGAGCCAGACAGCAGTGCCTCCTGTTTCCAGCAGCTGAGAGTGATCCCGAAG
GTCACCAAGCACCTGCTCTCAAACCCTGTGTTCACCTGCATCATCCTGGCCGCCTGCATG
GAGATTGCAGTGGTGGCTGGCTTCGCTGCCTTTTTGGGGAAGTACCTGGAGCAGCAGTTT
AACCTCACCACCTCTTCTGCCAACCAGCTGCTTGGGATGACTGCGATCCCGTGTGCTTGT
CTGGGTATCTTCCTGGGAGGTCTTTTGGTGAAGAAGCTCAGCCTGTCTGCCCTGGGGGCC
ATTCGGATGGCCATGCTCGTCAACCTGGTGTCCACTGCTTGCTACGTCTCCTTCCTCTTC
CTGGGCTGCGACACTGGCCCTGTGGCTGGGGTTACTGTTCCCTATGGAAACAGCACAGCA
CCTGGCTCAGCCCTGGACCCCTACTCGCCCTGCAATAATAACTGTGAATGCCAAACCGAT
TCCTTCACTCCAGTGTGTGGGGCAGATGGCATCACCTACCTGTCTGCCTGCTTTGCTGGC
TGCAACAGCACGAATCTCACGGGCTGTGCGTGCCTCACCACCGTCCCTGCTGAGAACGCA
ACCGTGGTTCCTGGAAAATGCCCCAGTCCTGGGTGCCAAGAGGCCTTCCTCACTTTCCTC
TGTGTGATGTGTATCTGCAGCCTGATCGGTGCCATGGCACAGACACCCTCAGTCATCATC
CTCATCAGGACAGTCAGCCCTGAACTCAAGTCTTACGCTTTGGGAGTTCTTTTTCTCCTC
CTTCGTTTGTTGGGCTTCATCCCTCCACCCCTCATCTTCGGGGCTGGCATCGACTCCACC
TGCCTGTTCTGGAGCACGTTCTGTGGGGAGCAAGGCGCCTGCGTCCTCTACGACAATGTG
GTCTACCGATACCTGTATGTCAGCATCGCCATCGCGCTCAAATCCTTCGCCTTCATCCTG
TACACCACCACGTGGCAGTGCCTGAGGAAAAACTATAAACGCTACATCAAAAACCACGAG
GGCGGGCTGAGCACCAGTGAGTTCTTTGCCTCTACTCTGACCCTAGACAACCTGGGGAGG
GACCCTGTGCCCGCAAACCAGACACATAGGACAAAGTTTATCTATAACCTGGAAGACCAT
GAGTGGTGTGAAAACATGGAGTCCGTTTTATAG
Protein Properties
Number of Residues 710
Molecular Weight 76552.1
Theoretical pI 6.71
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["41-61", "80-100", "109-129", "179-199", "213-233", "265-285", "353-373", "390-410", "423-443", "542-562", "573-593", "625-645"]
Protein Sequence 
>Solute carrier organic anion transporter family member 3A1
MQGKKPGGSSGGGRSGELQGDEAQRNKKKKKKVSCFSNIKIFLVSECALMLAQGTVGAYL
VSVLTTLERRFNLQSADVGVIASSFEIGNLALILFVSYFGARGHRPRLIGCGGIVMALGA
LLSALPEFLTHQYKYEAGEIRWGAEGRDVCAANGSGGDEGPDPDLICRNRTATNMMYLLL
IGAQVLLGIGATPVQPLGVSYIDDHVRRKDSSLYIGILFTMLVFGPACGFILGSFCTKIY
VDAVFIDTSNLDITPDDPRWIGAWWGGFLLCGALLFFSSLLMFGFPQSLPPHSEPAMESE
QAMLSEREYERPKPSNGVLRHPLEPDSSASCFQQLRVIPKVTKHLLSNPVFTCIILAACM
EIAVVAGFAAFLGKYLEQQFNLTTSSANQLLGMTAIPCACLGIFLGGLLVKKLSLSALGA
IRMAMLVNLVSTACYVSFLFLGCDTGPVAGVTVPYGNSTAPGSALDPYSPCNNNCECQTD
SFTPVCGADGITYLSACFAGCNSTNLTGCACLTTVPAENATVVPGKCPSPGCQEAFLTFL
CVMCICSLIGAMAQTPSVIILIRTVSPELKSYALGVLFLLLRLLGFIPPPLIFGAGIDST
CLFWSTFCGEQGACVLYDNVVYRYLYVSIAIALKSFAFILYTTTWQCLRKNYKRYIKNHE
GGLSTSEFFASTLTLDNLGRDPVPANQTHRTKFIYNLEDHEWCENMESVL
GenBank ID Protein 6683741
UniProtKB/Swiss-Prot ID Q9UIG8
UniProtKB/Swiss-Prot Entry Name SO3A1_HUMAN
PDB IDs Not Available
GenBank Gene ID AB031050
GeneCard ID SLCO3A1
GenAtlas ID SLCO3A1
HGNC ID HGNC:10952
References
General References Not Available