| Identification |
|---|
| HMDB Protein ID
| CDBP02448 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC |
| Description
| Not Available |
| Synonyms
|
- Alpha-1,2-mannosidase IC
- HMIC
- Mannosidase alpha class 1C member 1
- Processing alpha-1,2-mannosidase IC
|
| Gene Name
| MAN1C1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| Specific Function
| Involved in the maturation of Asn-linked oligosaccharides. Trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc and a small amount of Man(5)GlcNAc.
|
| GO Classification
|
| Biological Process |
| post-translational protein modification |
| protein N-linked glycosylation via asparagine |
| Cellular Component |
| integral to Golgi membrane |
| Component |
| membrane |
| cell part |
| Function |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| hydrolase activity, acting on glycosyl bonds |
| hydrolase activity, hydrolyzing o-glycosyl compounds |
| calcium ion binding |
| mannosidase activity |
| mannosyl-oligosaccharide mannosidase activity |
| ion binding |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| cation binding |
| Molecular Function |
| mannosyl-oligosaccharide 1,2-alpha-mannosidase activity |
| calcium ion binding |
|
| Cellular Location
|
- Golgi apparatus membrane
- Single-pass type II membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | protein glycosylation | Not Available | Not Available | | N-Glycan biosynthesis | Not Available |  | | Protein processing in endoplasmic reticulum | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 1 |
| Locus
| 1p35 |
| SNPs
| MAN1C1 |
| Gene Sequence
|
>1893 bp
ATGCTCATGAGGAAAGTGCCCGGCTTCGTCCCGGCCTCCCCGTGGGGGCTGCGGCTGCCG
CAGAAGTTCCTCTTCCTCCTCTTCCTCTCGGGCCTGGTCACCCTGTGCTTCGGGGCCCTC
TTCCTGCTGCCCCACTCCTCTCGCCTCAAGCGCCTCTTCCTGGCCCCCCGGACCCAGCAG
CCTGGTCTGGAAGTGGTGGCTGAAATCGCCGGCCATGCCCCGGCCCGCGAGCAGGAGCCG
CCTCCCAACCCGGCCCCCGCCGCGCCGGCCCCGGGCGAGGATGACCCCAGCAGCTGGGCC
AGTCCCCGCCGCAGGAAAGGGGGGCTGCGGCGCACCCGCCCCACTGGACCCCGCGAGGAG
GCCACGGCGGCCCGGGGCAATAGCATCCCGGCCTCCAGGCCCGGGGACGAGGGCGTCCCT
TTCCGCTTTGACTTCAACGCATTCCGGAGCCGTCTCCGCCACCCGGTCCTGGGAACGAGG
GCCGATGAGAGTCAGGAGCCCCAGAGCCAAGTGCGAGCCCAGCGGGAGAAAATCAAGGAG
ATGATGCAGTTTGCTTGGCAGAGCTATAAGCGTTATGCAATGGGGAAAAACGAACTCCGT
CCACTAACAAAAGATGGCTACGAGGGTAACATGTTCGGAGGCCTCAGCGGGGCAACAGTC
ATTGACTCCCTCGATACCCTCTACCTCATGGAGCTGAAGGAGGAGTTCCAGGAGGCCAAG
GCCTGGGTGGGAGAGAGCTTCCACCTGAACGTGAGCGGAGAAGCATCCTTGTTTGAGGTG
AACATCCGCTACATCGGGGGACTCCTCTCAGCCTTCTACCTGACAGGAGAAGAGGTGTTC
CGAATAAAGGCCATCAGGCTGGGAGAGAAGCTCCTGCCGGCGTTCAACACCCCCACGGGA
ATCCCAAAGGGCGTGGTGAGCTTCAAAAGTGGGAACTGGGGCTGGGCCACAGCCGGCAGC
AGCAGCATCTTGGCGGAGTTTGGATCCCTGCACTTGGAATTCTTACACCTCACTGAACTC
TCTGGCAACCAGGTCTTCGCTGAAAAGGTCAGGAACATCCGCAAGGTCCTCAGGAAGATC
GAAAAGCCCTTTGGCCTCTACCCCAACTTCCTCAGCCCAGTGAGTGGGAACTGGGTGCAA
CACCATGTCTCAGTTGGAGGACTCGGGGACAGTTTTTATGAATATTTGATCAAATCCTGG
TTGATGTCGGGCAAGACAGATATGGAGGCTAAAAATATGTACTACGAAGCCTTGGAGGCG
ATAGAGACCTACTTGCTGAATGTCTCTCCCGGGGGGCTGACCTACATTGCCGAGTGGCGA
GGGGGGATTCTGGACCACAAGATGGGGCACCTGGCCTGTTTCTCCGGGGGCATGATCGCC
CTTGGCGCCGAGGATGCCAAGGAAGAAAAGAGGGCCCACTACCGAGAGCTCGCAGCCCAG
ATCACCAAGACGTGTCACGAGTCATACGCCCGCTCAGACACCAAACTTGGGCCTGAGGCC
TTCTGGTTTAACTCCGGCAGAGAGGCCGTGGCCACCCAGCTGAGCGAGAGCTACTACATC
CTCCGGCCAGAGGTGGTGGAGAGCTACATGTACCTGTGGCGACAGACCCACAACCCCATC
TACAGGGAGTGGGGCTGGGAGGTGGTGCTGGCCTTGGAGAAATACTGTCGGACAGAAGCC
GGTTTCTCTGGGATCCAAGACGTGTACAGTAGCACCCCCAACCACGACAACAAGCAGCAG
AGCTTCTTTCTAGCGGAGACACTAAAGTATCTCTATCTTCTGTTCTCTGAAGATGACTTG
CTCTCCCTGGAAGACTGGGTGTTCAACACCGAGGCCCACCCACTCCCGGTGAACCACTCA
GACAGCTCCGGCAGAGCCTGGGGCAGACACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 630 |
| Molecular Weight
| 70910.025 |
| Theoretical pI
| 7.465 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
MLMRKVPGFVPASPWGLRLPQKFLFLLFLSGLVTLCFGALFLLPHSSRLKRLFLAPRTQQ
PGLEVVAEIAGHAPAREQEPPPNPAPAAPAPGEDDPSSWASPRRRKGGLRRTRPTGPREE
ATAARGNSIPASRPGDEGVPFRFDFNAFRSRLRHPVLGTRADESQEPQSQVRAQREKIKE
MMQFAWQSYKRYAMGKNELRPLTKDGYEGNMFGGLSGATVIDSLDTLYLMELKEEFQEAK
AWVGESFHLNVSGEASLFEVNIRYIGGLLSAFYLTGEEVFRIKAIRLGEKLLPAFNTPTG
IPKGVVSFKSGNWGWATAGSSSILAEFGSLHLEFLHLTELSGNQVFAEKVRNIRKVLRKI
EKPFGLYPNFLSPVSGNWVQHHVSVGGLGDSFYEYLIKSWLMSGKTDMEAKNMYYEALEA
IETYLLNVSPGGLTYIAEWRGGILDHKMGHLACFSGGMIALGAEDAKEEKRAHYRELAAQ
ITKTCHESYARSDTKLGPEAFWFNSGREAVATQLSESYYILRPEVVESYMYLWRQTHNPI
YREWGWEVVLALEKYCRTEAGFSGIQDVYSSTPNHDNKQQSFFLAETLKYLYLLFSEDDL
LSLEDWVFNTEAHPLPVNHSDSSGRAWGRH
|
| External Links |
|---|
| GenBank ID Protein
| 9664312 |
| UniProtKB/Swiss-Prot ID
| Q9NR34 |
| UniProtKB/Swiss-Prot Entry Name
| MA1C1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF261655 |
| GeneCard ID
| MAN1C1 |
| GenAtlas ID
| MAN1C1 |
| HGNC ID
| HGNC:19080 |
| References |
|---|
| General References
| Not Available |