| Identification |
|---|
| HMDB Protein ID
| CDBP02445 |
| Secondary Accession Numbers
| Not Available |
| Name
| Retinol dehydrogenase 14 |
| Description
| Not Available |
| Synonyms
|
- Alcohol dehydrogenase PAN2
|
| Gene Name
| RDH14 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in oxidoreductase activity |
| Specific Function
| Exhibits an oxidoreductive catalytic activity towards retinoids. Most efficient as an NADPH-dependent retinal reductase. Displays high activity toward 9-cis and all-trans-retinol. No steroid dehydrogenase activity detected |
| GO Classification
|
| Function |
| binding |
| catalytic activity |
| oxidoreductase activity |
| Process |
| metabolic process |
| oxidation reduction |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p24.2 |
| SNPs
| RDH14 |
| Gene Sequence
|
>1011 bp
ATGGCAGTGGCCACTGCGGCGGCAGTACTGGCCGCTCTGGGCGGGGCGCTGTGGCTGGCG
GCCCGCCGGTTCGTGGGGCCCAGGGTCCAGCGGCTGCGCAGAGGCGGGGACCCCGGCCTC
ATGCACGGGAAGACTGTGCTGATCACCGGGGCGAACAGCGGCCTGGGCCGCGCCACGGCC
GCCGAGCTACTGCGCCTGGGAGCGCGGGTGATCATGGGCTGCCGGGACCGCGCGCGCGCC
GAGGAGGCGGCGGGTCAGCTCCGCCGCGAGCTCCGCCAGGCCGCGGAGTGCGGCCCAGAG
CCTGGCGTCAGCGGGGTGGGCGAGCTCATAGTCCGGGAGCTGGACCTCGCCTCGCTGCGC
TCGGTGCGCGCCTTCTGCCAGGAAATGCTCCAGGAAGAGCCTAGGCTGGATGTCTTGATC
AATAACGCAGGGATCTTCCAGTGCCCTTACATGAAGACTGAAGATGGGTTTGAGATGCAG
TTCGGAGTGAACCATCTGGGGCACTTTCTACTCACCAATCTTCTCCTTGGACTCCTCAAA
AGTTCAGCTCCCAGCAGGATTGTGGTAGTTTCTTCCAAACTTTATAAATACGGAGACATC
AATTTTGATGACTTGAACAGTGAACAAAGCTATAATAAAAGCTTTTGTTATAGCCGGAGC
AAACTGGCTAACATTCTTTTTACCAGGGAACTAGCCCGCCGCTTAGAAGGCACAAATGTC
ACCGTCAATGTGTTGCATCCTGGTATTGTACGGACAAATCTGGGGAGGCACATACACATT
CCACTGTTGGTCAAACCACTCTTCAATTTGGTGTCATGGGCTTTTTTCAAAACTCCAGTA
GAAGGTGCCCAGACTTCCATTTATTTGGCCTCTTCACCTGAGGTAGAAGGAGTGTCAGGA
AGATACTTTGGGGATTGTAAAGAGGAAGAACTGTTGCCCAAAGCTATGGATGAATCTGTT
GCAAGAAAACTCTGGGATATCAGTGAAGTGATGGTTGGCCTGCTAAAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 336 |
| Molecular Weight
| 36864.4 |
| Theoretical pI
| 9.0 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Retinol dehydrogenase 14
MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA
AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR
SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK
SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV
TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG
RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9HBH5 |
| UniProtKB/Swiss-Prot Entry Name
| RDH14_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF237952 |
| GeneCard ID
| RDH14 |
| GenAtlas ID
| RDH14 |
| HGNC ID
| HGNC:19979 |
| References |
|---|
| General References
| Not Available |