| Identification |
|---|
| HMDB Protein ID
| CDBP02436 |
| Secondary Accession Numbers
| Not Available |
| Name
| Anion exchange transporter |
| Description
| Not Available |
| Synonyms
|
- Solute carrier family 26 member 7
|
| Gene Name
| SLC26A7 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in transporter activity |
| Specific Function
| Acts as a sodium-independent DIDS-sensitive anion exchanger mediating bicarbonate, chloride, sulfate and oxalate transport. May play a role in the maintenance of the electrolyte and acid-base homeostasis in the kidney, by acting as a distal excretory segment-specific anion exchanger. Plays a major role in gastric acid secretion |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| transporter activity |
| Process |
| transport |
| transmembrane transport |
| establishment of localization |
|
| Cellular Location
|
- Multi-pass membrane protein
- Recycling endosome membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q23 |
| SNPs
| SLC26A7 |
| Gene Sequence
|
>1971 bp
ATGACAGGAGCAAAGAGGAAAAAGAAAAGCATGCTTTGGAGCAAGATGCATACCCCCCAG
TGTGAAGACATTATACAGTGGTGTAGAAGGCGACTGCCCATTTTGGATTGGGCACCACAT
TACAATCTGAAAGAAAACTTGCTTCCAGACACTGTGTCTGGGATAATGTTGGCAGTTCAA
CAGGTGACCCAAGGATTGGCCTTTGCTGTTCTCTCATCTGTGCACCCAGTGTTTGGTTTA
TATGGGTCTCTGTTTCCTGCCATAATTTATGCCATATTTGGAATGGGACATCATGTTGCC
ACAGGCACCTTTGCCTTGACATCCTTAATATCAGCCAACGCCGTGGAACGGATTGTCCCT
CAGAACATGCAGAATCTCACCACACAGAGTAACACAAGCGTGCTGGGCTTATCCGACTTT
GAAATGCAAAGGATCCACGTTGCTGCAGCAGTTTCCTTCTTGGGAGGTGTGATTCAGGTG
GCCATGTTTGTGCTGCAACTGGGCAGTGCCACATTTGTGGTCACAGAGCCTGTGATCAGC
GCAATGACAACTGGGGCTGCCACCCATGTGGTGACTTCACAAGTCAAATATCTCTTGGGA
ATGAAAATGCCATATATATCCGGACCACTTGGATTCTTTTATATTTATGCATATGTTTTT
GAAAACATCAAGTCTGTGCGACTGGAGGCATTGCTTTTATCCTTGCTGAGCATTGTGGTC
CTTGTTCTTGTTAAAGAGCTGAATGAACAGTTTAAAAGGAAAATTAAAGTTGTTCTTCCT
GTAGATTTAGTTTTGATTATTGCTGCATCATTTGCTTGTTATTGCACCAATATGGAAAAC
ACATATGGATTAGAAGTAGTTGGTCATATTCCACAAGGAATTCCCTCACCTAGAGCTCCC
CCGATGAACATCCTCTCTGCGGTGATCACTGAAGCTTTCGGAGTGGCACTTGTAGGCTAT
GTGGCCTCACTGGCTCTTGCTCAAGGATCTGCCAAAAAATTCAAATATTCAATTGATGAC
AACCAGGAATTTTTGGCCCATGGCCTCAGCAATATAGTTTCTTCATTTTTCTTCTGCATA
CCAAGTGCTGCTGCCATGGGAAGGACGGCTGGCCTGTACAGCACAGGAGCGAAGACACAG
GTGGCTTGTCTAATATCTTGCATTTTCGTCCTTATAGTCATCTATGCAATAGGACCTTTG
CTTTACTGGCTGCCCATGTGTGTCCTTGCAAGCATTATTGTTGTGGGACTGAAGGGAATG
CTAATACAGTTCCGAGATTTAAAAAAATATTGGAATGTGGATAAAATCGATTGGGGAATA
TGGGTCAGTACATATGTATTTACAATATGCTTTGCTGCCAATGTGGGACTGCTGTTTGGT
GTTGTTTGTACCATAGCTATAGTGATAGGACGCTTCCCAAGAGCAATGACTGTAAGTATA
AAAAATATGAAAGAAATGGAATTTAAAGTGAAGACAGAAATGGACAGTGAAACCCTGCAG
CAGGTGAAAATTATCTCAATAAACAACCCGCTTGTTTTCCTGAATGCAAAAAAATTTTAT
ACTGATTTAATGAACATGATCCAAAAGGAAAATGCCTGTAATCAGCCACTTGATGATATC
AGCAAGTGTGAACAAAACACATTGCTTAATTCCCTATCCAATGGCAACTGCAATGAAGAA
GCTTCACAGTCCTGCCCTAATGAGAAGTGTTATTTAATCCTGGATTGCAGTGGATTTACC
TTTTTTGACTATTCTGGAGTCTCCATGCTTGTTGAGGTTTACATGGACTGTAAAGGCAGG
AGTGTGGATGTATTGTTAGCCCATTGTACAGCTTCCTTGATAAAAGCAATGACGTATTAT
GGAAACCTAGACTCAGAGAAACCAATTTTTTTTGAATCGGTATCTGCTGCAATAAGTCAT
ATCCATTCAAATAAGAATTTGAGCAAACTCAGTGACCACAGTGAAGTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 656 |
| Molecular Weight
| 72212.2 |
| Theoretical pI
| 7.96 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["76-96", "145-165", "167-187", "203-223", "228-248", "255-275", "307-327", "344-364", "384-404", "405-425", "449-469"]
|
| Protein Sequence
|
>Anion exchange transporter
MTGAKRKKKSMLWSKMHTPQCEDIIQWCRRRLPILDWAPHYNLKENLLPDTVSGIMLAVQ
QVTQGLAFAVLSSVHPVFGLYGSLFPAIIYAIFGMGHHVATGTFALTSLISANAVERIVP
QNMQNLTTQSNTSVLGLSDFEMQRIHVAAAVSFLGGVIQVAMFVLQLGSATFVVTEPVIS
AMTTGAATHVVTSQVKYLLGMKMPYISGPLGFFYIYAYVFENIKSVRLEALLLSLLSIVV
LVLVKELNEQFKRKIKVVLPVDLVLIIAASFACYCTNMENTYGLEVVGHIPQGIPSPRAP
PMNILSAVITEAFGVALVGYVASLALAQGSAKKFKYSIDDNQEFLAHGLSNIVSSFFFCI
PSAAAMGRTAGLYSTGAKTQVACLISCIFVLIVIYAIGPLLYWLPMCVLASIIVVGLKGM
LIQFRDLKKYWNVDKIDWGIWVSTYVFTICFAANVGLLFGVVCTIAIVIGRFPRAMTVSI
KNMKEMEFKVKTEMDSETLQQVKIISINNPLVFLNAKKFYTDLMNMIQKENACNQPLDDI
SKCEQNTLLNSLSNGNCNEEASQSCPNEKCYLILDCSGFTFFDYSGVSMLVEVYMDCKGR
SVDVLLAHCTASLIKAMTYYGNLDSEKPIFFESVSAAISHIHSNKNLSKLSDHSEV
|
| External Links |
|---|
| GenBank ID Protein
| 15341552 |
| UniProtKB/Swiss-Prot ID
| Q8TE54 |
| UniProtKB/Swiss-Prot Entry Name
| S26A7_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF331521 |
| GeneCard ID
| SLC26A7 |
| GenAtlas ID
| SLC26A7 |
| HGNC ID
| HGNC:14467 |
| References |
|---|
| General References
| Not Available |