| Identification |
|---|
| HMDB Protein ID
| CDBP02433 |
| Secondary Accession Numbers
| Not Available |
| Name
| Glucose-6-phosphatase 2 |
| Description
| Not Available |
| Synonyms
|
- G-6-Pase 2
- G6Pase 2
- Islet-specific glucose-6-phosphatase catalytic subunit-related protein
|
| Gene Name
| G6PC2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in catalytic activity |
| Specific Function
| May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity).
|
| GO Classification
|
| Biological Process |
| small molecule metabolic process |
| glucose transport |
| gluconeogenesis |
| glucose homeostasis |
| regulation of insulin secretion |
| carbohydrate metabolic process |
| transmembrane transport |
| Cellular Component |
| endoplasmic reticulum membrane |
| integral to membrane |
| Component |
| membrane |
| cell part |
| Function |
| catalytic activity |
| Molecular Function |
| glucose-6-phosphatase activity |
|
| Cellular Location
|
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycolysis / Gluconeogenesis | Not Available |  | | PI3K-Akt signaling pathway | Not Available |  | | Insulin signaling pathway | Not Available |  | | Adipocytokine signaling pathway | Not Available |  | | Carbohydrate digestion and absorption | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q24.3 |
| SNPs
| G6PC2 |
| Gene Sequence
|
>1068 bp
ATGGATTTCCTTCACAGGAATGGAGTGCTCATAATTCAGCATTTGCAGAAGGACTACCGA
GCTTACTACACTTTTCTAAATTTTATGTCCAATGTTGGAGACCCCAGGAATATCTTTTTC
ATTTATTTTCCACTTTGTTTTCAATTTAATCAGACAGTTGGAACCAAGATGATATGGGTA
GCAGTCATTGGGGATTGGTTAAATCTTATATTTAAATGGATATTATTTGGTCATCGACCT
TACTGGTGGGTCCAAGAAACTCAGATTTACCCAAATCACTCAAGTCCATGCCTTGAACAG
TTCCCTACTACATGTGAAACAGGTCCAGGAAGTCCATCTGGCCATGCAATGGGCGCATCC
TGTGTCTGGTATGTCATGGTAACCGCTGCCCTGAGCCACACTGTCTGTGGGATGGATAAG
TTCTCTATCACTCTGCACAGACTGACCTGGTCATTTCTTTGGAGTGTTTTTTGGTTGATT
CAAATCAGTGTCTGCATCTCCAGAGTATTCATAGCAACACATTTTCCTCATCAAGTTATT
CTTGGAGTAATTGGTGGCATGCTGGTGGCAGAGGCCTTTGAACACACTCCAGGCATCCAA
ACGGCCAGTCTGGGCACATACCTGAAGACCAACCTCTTTCTCTTCCTGTTTGCAGTTGGC
TTTTACCTGCTTCTTAGGGTGCTCAACATTGACCTGCTGTGGTCCGTGCCCATAGCCAAA
AAGTGGTGTGCTAACCCCGACTGGATCCACATTGACACCACGCCTTTTGCTGGACTCGTG
AGAAACCTTGGGGTCCTCTTTGGCTTGGGCTTTGCAATCAACTCAGAGATGTTCCTCCTG
AGCTGCCGAGGGGGAAATAACTACACACTGAGCTTCCGGTTGCTCTGTGCCTTGACCTCA
TTGACAATACTGCAGCTCTACCATTTCCTCCAGATCCCGACTCACGAAGAGCATTTATTT
TATGTGCTGTCTTTTTGTAAAAGTGCATCCATTCCCCTAACTGTGGTTGCTTTCATTCCC
TACTCTGTTCATATGTTAATGAAACAAAGCGGAAAGAAGAGTCAGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 355 |
| Molecular Weight
| 17756.465 |
| Theoretical pI
| 8.121 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Glucose-6-phosphatase 2
MDFLHRNGVLIIQHLQKDYRAYYTFLNFMSNVGDPRNIFFIYFPLCFQFNQTVGTKMIWV
AVIGDWLNLIFKWILFGHRPYWWVQETQIYPNHSSPCLEQFPTTCETGPGSPSGHAMGAS
CVWYVMVTAALSHTVCGMDKFSITLHRLTWSFLWSVFWLIQISVCISRVFIATHFPHQVI
LGVIGGMLVAEAFEHTPGIQTASLGTYLKTNLFLFLFAVGFYLLLRVLNIDLLWSVPIAK
KWCANPDWIHIDTTPFAGLVRNLGVLFGLGFAINSEMFLLSCRGGNNYTLSFRLLCALTS
LTILQLYHFLQIPTHEEHLFYVLSFCKSASIPLTVVAFIPYSVHMLMKQSGKKSQ
|
| External Links |
|---|
| GenBank ID Protein
| 9082328 |
| UniProtKB/Swiss-Prot ID
| Q9NQR9 |
| UniProtKB/Swiss-Prot Entry Name
| G6PC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF283835 |
| GeneCard ID
| G6PC2 |
| GenAtlas ID
| G6PC2 |
| HGNC ID
| HGNC:28906 |
| References |
|---|
| General References
| Not Available |