| Identification |
|---|
| HMDB Protein ID
| CDBP02431 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inorganic pyrophosphatase 2, mitochondrial |
| Description
| Not Available |
| Synonyms
|
- PPase 2
- Pyrophosphatase SID6-306
- Pyrophosphate phospho-hydrolase 2
|
| Gene Name
| PPA2 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in magnesium ion binding |
| Specific Function
| Not Available |
| GO Classification
|
| Biological Process |
| diphosphate metabolic process |
| tRNA aminoacylation for protein translation |
| phosphate-containing compound metabolic process |
| Cellular Component |
| mitochondrial matrix |
| Component |
| cell part |
| intracellular part |
| cytoplasm |
| Function |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides |
| pyrophosphatase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| magnesium ion binding |
| inorganic diphosphatase activity |
| hydrolase activity, acting on acid anhydrides |
| Molecular Function |
| magnesium ion binding |
| inorganic diphosphatase activity |
| Process |
| phosphorus metabolic process |
| phosphate metabolic process |
| metabolic process |
| cellular metabolic process |
|
| Cellular Location
|
- Mitochondrion (Potential)
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Oxidative phosphorylation | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 4 |
| Locus
| 4q25 |
| SNPs
| PPA2 |
| Gene Sequence
|
>1005 bp
ATGAGCGCGCTGCTGCGGCTGCTGCGCACGGGTGCCCCAGCCGCTGCGTGCCTGCGGTTG
GGGACCAGTGCAGGGACCGGGTCGCGCCGTGCTATGGCCCTGTACCACACTGAGGAGCGC
GGCCAGCCCTGCTCGCAGAATTACCGCCTCTTCTTTAAGAATGTAACTGGTCACTACATT
TCCCCCTTTCATGATATTCCTCTGAAGGTGAACTCTAAAGAGGAAAATGGCATTCCTATG
AAGAAAGCACGAAATGATGAATATGAGAATCTGTTTAATATGATTGTAGAAATACCTCGG
TGGACAAATGCTAAAATGGAGATTGCCACCAAGGAGCCAATGAATCCCATTAAACAATAT
GTAAAGGATGGAAAGCTACGCTATGTGGCGAATATCTTCCCTTACAAGGGTTATATATGG
AATTATGGTACCCTCCCTCAGACTTGGGAAGATCCCCATGAAAAAGATAAGAGCACGAAC
TGCTTTGGAGATAATGATCCTATTGATGTTTGCGAAATAGGCTCAAAGATTCTTTCTTGT
GGAGAAGTTATTCATGTGAAGATCCTTGGAATTTTGGCTCTTATTGATGAAGGTGAAACA
GATTGGAAATTAATTGCTATCAATGCGAATGATCCTGAAGCCTCAAAGTTTCATGATATT
GATGATGTTAAGAAGTTCAAACCGGGTTACCTGGAAGCTACTCTTAATTGGTTTAGATTA
TATAAGGTACCAGATGGAAAACCAGAAAACCAGTTTGCTTTTAATGGAGAATTCAAAAAC
AAGGCTTTTGCTCTTGAAGTTATTAAATCCACTCATCAATGTTGGAAAGCATTGCTTATG
AAGAAGTGTAATGGAGGAGCTATAAATTGCACAAACGTGCAGATATCTGATAGCCCTTTC
CGTTGCACTCAAGAGGAAGCAAGATCATTAGTTGAATCGGTATCATCTTCACCAAATAAA
GAAAGTAATGAAGAAGAGCAAGTGTGGCACTTCCTTGGCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 334 |
| Molecular Weight
| 34657.47 |
| Theoretical pI
| 8.45 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Inorganic pyrophosphatase 2, mitochondrial
MSALLRLLRTGAPAAACLRLGTSAGTGSRRAMALYHTEERGQPCSQNYRLFFKNVTGHYI
SPFHDIPLKVNSKEENGIPMKKARNDEYENLFNMIVEIPRWTNAKMEIATKEPMNPIKQY
VKDGKLRYVANIFPYKGYIWNYGTLPQTWEDPHEKDKSTNCFGDNDPIDVCEIGSKILSC
GEVIHVKILGILALIDEGETDWKLIAINANDPEASKFHDIDDVKKFKPGYLEATLNWFRL
YKVPDGKPENQFAFNGEFKNKAFALEVIKSTHQCWKALLMKKCNGGAINCTNVQISDSPF
RCTQEEARSLVESVSSSPNKESNEEEQVWHFLGK
|
| External Links |
|---|
| GenBank ID Protein
| 29171702 |
| UniProtKB/Swiss-Prot ID
| Q9H2U2 |
| UniProtKB/Swiss-Prot Entry Name
| IPYR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_176869.2 |
| GeneCard ID
| PPA2 |
| GenAtlas ID
| PPA2 |
| HGNC ID
| HGNC:28883 |
| References |
|---|
| General References
| Not Available |