| Identification |
|---|
| HMDB Protein ID
| CDBP02424 |
| Secondary Accession Numbers
| Not Available |
| Name
| Selenocysteine lyase |
| Description
| Not Available |
| Synonyms
|
- hSCL
|
| Gene Name
| SCLY |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabolic process |
| Specific Function
| Catalyzes the decomposition of L-selenocysteine to L-alanine and elemental selenium (By similarity).
|
| GO Classification
|
| Biological Process |
| cellular amino acid metabolic process |
| Cellular Component |
| cytosol |
| Function |
| binding |
| catalytic activity |
| cofactor binding |
| pyridoxal phosphate binding |
| Molecular Function |
| transferase activity |
| pyridoxal phosphate binding |
| selenocysteine lyase activity |
| Process |
| metabolic process |
|
| Cellular Location
|
- Cytoplasm
- cytosol
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Selenocompound metabolism | Not Available |  | | Selenoamino Acid Metabolism |    | |
|
| Gene Properties |
|---|
| Chromosome Location
| 2 |
| Locus
| 2q37.3 |
| SNPs
| SCLY |
| Gene Sequence
|
>1338 bp
ATGGAGGCGGCCGTGGCGCCGGGGAGGGATGCGCCGGCACCCGCGGCGAGTCAGCCCAGC
GGCTGCGGGAAACACAACTCGCCGGAGAGGAAAGTTTATATGGACTATAATGCAACGACT
CCCCTGGAGCCAGAAGTTATCCAGGCCATGACCAAGGCCATGTGGGAAGCCTGGGGAAAT
CCCAGCAGCCCGTATTCAGCAGGAAGAAAGGCCAAGGATATTATAAATGCAGCTCGGGAA
AGCCTCGCGAAGATGATAGGGGGGAAACCTCAAGATATAATCTTCACTTCCGGGGGCACT
GAGTCAAATAATTTAGTAATCCATTCTGTGGTGAAACATTTCCACGCAAACCAGACCTCA
AAGGGACACACAGGTGGGCACCACAGCCCAGTGAAGGGGGCCAAGCCCCATTTCATTACT
TCCTCGGTGGAACACGACTCCATCCGGCTGCCCCTGGAGCACCTGGTGGAAGAACAAGTG
GCAGCGGTCACCTTTGTCCCGGTGTCCAAGGTGAGCGGGCAGGCAGAGGTGGACGACATC
CTCGCGGCAGTCCGCCCGACCACACGCCTCGTGACCATCATGCTGGCCAACAATGAGACT
GGCATTGTCATGCCTGTCCCTGAAATCAGTCAGCGCATTAAAGCCCTGAACCAGGAACGG
GTGGCAGCTGGGCTACCTCCCATCCTCGTGCACACGGATGCTGCACAGGCCTTGGGGAAG
CAGCGCGTGGATGTGGAGGACCTGGGCGTGGACTTCCTTACAATCGTGGGGCACAAGTTT
TATGGTCCCAGGATTGGCGCACTTTATATACGAGGACTTGGTGAATTTACCCCTCTCTAC
CCTATGCTATTTGGAGGTGGACAAGAACGGAATTTCAGGCCAGGGACAGAGAACACCCCA
ATGATTGCTGGCCTTGGGAAGGCCGCGGAGCTGGTGACCCAGAACTGCGAGGCTTATGAG
GCCCACATGAGGGACGTCCGCGACTACCTGGAAGAGAGGCTGGAAGCTGAATTCGGTCAG
AAGAGAATCCATCTGAATAGCCAGTTTCCAGGCACCCAGCGGCTTCCCAATACCTGTAAC
TTTTCCATCCGGGGACCCCGGCTTCAAGGCCACGTGGTGCTTGCGCAGTGCCGAGTGCTG
ATGGCCAGTGTGGGGGCCGCGTGCCACTCGGACCACGGGGACCAGCCGTCCCCAGTGCTG
CTGAGCTACGGTGTCCCCTTCGACGTGGCCAGGAACGCGCTCCGGCTCAGCGTGGGCCGC
AGCACCACCAGGGCCGAGGTGGACCTCGTCGTGCAGGACCTGAAGCAGGCCGTGGCGCAG
CTGGAGGACCAGGCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 445 |
| Molecular Weight
| 48793.15 |
| Theoretical pI
| 7.124 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Selenocysteine lyase
MEAAVAPGRDAPAPAASQPSGCGKHNSPERKVYMDYNATTPLEPEVIQAMTKAMWEAWGN
PSSPYSAGRKAKDIINAARESLAKMIGGKPQDIIFTSGGTESNNLVIHSVVKHFHANQTS
KGHTGGHHSPVKGAKPHFITSSVEHDSIRLPLEHLVEEQVAAVTFVPVSKVSGQAEVDDI
LAAVRPTTRLVTIMLANNETGIVMPVPEISQRIKALNQERVAAGLPPILVHTDAAQALGK
QRVDVEDLGVDFLTIVGHKFYGPRIGALYIRGLGEFTPLYPMLFGGGQERNFRPGTENTP
MIAGLGKAAELVTQNCEAYEAHMRDVRDYLEERLEAEFGQKRIHLNSQFPGTQRLPNTCN
FSIRGPRLQGHVVLAQCRVLMASVGAACHSDHGDQPSPVLLSYGVPFDVARNALRLSVGR
STTRAEVDLVVQDLKQAVAQLEDQA
|
| External Links |
|---|
| GenBank ID Protein
| 156713448 |
| UniProtKB/Swiss-Prot ID
| Q96I15 |
| UniProtKB/Swiss-Prot Entry Name
| SCLY_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_016510.4 |
| GeneCard ID
| SCLY |
| GenAtlas ID
| SCLY |
| HGNC ID
| HGNC:18161 |
| References |
|---|
| General References
| Not Available |